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Medicine Overview of Fevigra 100mg Tablet
বাংলা
English
Indication
Indicated for premenopausal women with acquired, generalized, hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance,
Adult Dose
Hypoactive Sexual Desire Disorder
Indicated for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not caused by a coexisting medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance
100 mg PO once daily at bedtime
Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression
Discontinued after 8 weeks if no improvement
Contraindication
Use with alcohol
Co-administration with moderate or strong CYP3A4 inhibitors
Any degree of hepatic impairment
Mode of Action
Postsynaptic serotonin-1A (5HT-1A) receptor agonist and 5HT-2A receptor antagonist; also elicits moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors
The mechanism of action HSDD is not known; may work by restoring prefrontal cortex control over the brain's motivation/rewards structures, enabling sexual desire to manifest; this may occur by increasing dopamine and norepinephrine while transiently decreasing serotonin in the brain's prefrontal cortex, which may be accomplished by reduced glutamate transmission
Precaution
Coadministration with alcohol increases the risk of severe hypotension and syncope (also see Contraindications and Black Box Warnings) Coadministration with moderate or strong CYP3A4 inhibitors is significantly increases flibanserin concentrations, which can lead to hypotension and syncope (also see Contraindications, Black Box Warnings, and Dosing) Concomitant use of multiple weak CYP3A4 inhibitors that may include herbal supplements (eg, ginkgo, resveratrol) or nonprescription drugs (eg, cimetidine) could also lead to clinically relevant increases in flibanserin concentrations that may increase the risk of hypotension and syncope Causes CNS depression (eg, somnolence, sedation); risk of CNS depression is increased if taken during waking...
... Show moreSide Effect
>10%
Dizziness (11.4%)
Somnolence (11.2%)
Nausea (10.4%)
1-10%
Fatigue (9.2%)
Insomnia (4.9%)
Dry mouth (2.4%)
Anxiety (1.8%)
Constipation (1.6%)
Abdominal pain (1.5%)
Metrorrhagia (1.4%)
Rash (1.3%)
Sedation (1.3%)
Vertigo (1%)
Pregnancy Category Note
Pregnancy There are no studies in pregnant women to inform whether there is a drug-associated risk in humans Animal data In animals, fetal toxicity only occurred in the presence of significant maternal toxicity, including reductions in weight gain and sedation Adverse reproductive and developmental effects consisted of decreased fetal weight, structural anomalies, and increases in fetal loss at exposures greater than 15 times exposures achieved with the recommended human dosage Lactation Unknown if distributed in human breast milk Excreted in rat milk Unknown whether flibanserin has effects on the breastfed infant or if it affects milk production Because of the...
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