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Imruza 25

Tablet-(25mg)
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Beacon Pharmaceuticals PLC

Generic: Azathioprine

10 Tablets (1 Strip)
৳ 112
৳ 120
7% OFF

Medicine Overview of Imruza 25mg Tablet

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Introduction

Imruza 25 belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by weakening your body’s immune system, so it does not attack the new organ. The amount of Imruza 25 to be taken and how often you need to take it will depend on the type of transplant you have. Follow your doctor's instructions on this. You should take it along with food. Swallow it as a whole, do not crush, chew, break, or open them. Take the medicine regularly to get the most benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection. It has many potential side effects. The most common are loss of appetite, nausea and increased risk of bleeding. Because it suppresses your immune system, you may catch more infections than usual. There's also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use a protective cream. There is a long list of potential side effects. You should ask your doctor about them and what signs to look out for because some can be serious and need urgent medical attention. Imruza 25 can cause birth defects and miscarriages so do not take it if you are pregnant, planning to become pregnant or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. Your doctor also needs to know what other medicines you are taking as there are many which interact with this medicine and affect the way it works. You will have regular tests to check for any changes in the number of your blood cells.

Uses of Imruza 25

  • Prevention of organ rejection in transplant patients
  • Rheumatoid arthritis

Side effects of Imruza 25

Common
  • Decreased white blood cell count
  • Increased bleeding tendency
  • Nausea
  • Infection
  • Loss of appetite

How to use Imruza 25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imruza 25 is to be taken with food.

How Imruza 25 works

Imruza 25 is an immunosuppressant. It reduces the action of body's own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

Quick Tips

  • Your doctor has prescribed Imruza 25 to stop the body from rejecting a transplanted organ (e.g. kidney, heart or liver).
  • Imruza 25 also relieves joint pain and inflammation in rheumatoid arthritis.
  • You may have to take additional medications along with Imruza 25 for better relief of symptoms.
  • Avoid contact with people who have cold, flu or other contagious illness. Notify your doctor if you have any signs of infection such as a fever or sore throat.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Brief Description

Indication

Rheumatoid arthritis, Prevention of rejection in organ and tissue transplantation, Auto-immune diseases, Renal homotransplantation

Administration

May be taken with or without food. Preferably taken w/ or after meals to reduce GI discomfort.

Adult Dose

Rheumatoid Arthritis 1 mg/kg/day PO initially in single daily dose or divided q12hr; may be increased by 0.5 mg/kg/day after 6-8 weeks, then by 0.5 mg/kg/day every 4 weeks; not to exceed 2.5 mg/kg/day Maintenance: Reduce daily dose by 0.5 mg/kg every 4 weeks until lowest effective dosage is reached Kidney Transplantation Prevention of transplant rejection 3-5 mg/kg/day PO initially on day of transplant or 3 days before transplant (rare) Maintenance: 1-3 mg/kg/day PO Auto-immune diseases 1-3 mg/kg/day. Hepatic Impairment Reduce dose.

Child Dose

Juvenile Idiopathic Arthritis 1 mg/kg/day PO initially in single daily dose or divided q12hr; may be increased by 0.5 mg/kg/day after 6-8 weeks, then by 0.5 mg/kg/day every 4 weeks; not to exceed 2.5 mg/kg/day Maintenance: Reduce daily dose by 0.5 mg/kg every 4 weeks until lowest effective dosage is reached

Renal Dose

Reduce dose.

Contraindication

Hypersensitivity; previous treatment with alkylating agents; pregnancy, lactation.

Mode of Action

Azathioprine is an imidazolyl derivative of mercaptopurine, which inhibits DNA, RNA and protein synthesis and antagonises purine synthesis. It also inhibits mitosis and interferes with cellular metabolism of susceptible organisms. Azathioprine inj should be converted to oral therapy as soon as the drug can be tolerated.

Precaution

Increased risk of serious infections and neoplasia in chronic immunosuppression; leucopenia, thrombocytopenia, renal or hepatic impairment. Increased risk of haematologic toxicity in patients with thiopurine methyltransferase deficiency. Monitor CBC (including platelet count) wkly during 1st mth, twice mthly for 2nd and 3rd mth, then mthly; monitor more frequently if there are dosage adjustments. Monitor LFT periodically; discontinue treatment if jaundice occurs. Reduce dose promptly or withdraw drug temporary if there is rapid decrease/persistently low WBC or signs of bone marrow depression. Dose reduction may be necessary in patients with reduced TPMT (thiopurine methyltransferase) activity. Lactation: Drug excreted at low levels in breast milk; use not recommended

Side Effect

>10% Leukopenia (28-50%),Infection (20%) <1% Lymphoma Frequency Not Defined Fever, chills; bone marrow depression, thrombocytopenia or anaemia; anorexia, nausea, diarrhoea; arthralgias; secondary infections; hepatotoxicity, rash, alopoecia. Potentially Fatal: Myelosuppression, mutagenicity and carcinogenicity; veno-occlussive liver disease.

Pregnancy Category Note

Pregnancy category: D Lactation: Drug excreted at low levels in breast milk; use not recommended

Interaction

Increased risk of haematotoxicity with aminosalicylates, drugs that affect myelopoesis e.g. co-trimoxazole or trimethoprim. Increased risk of infections with intra-uterine devices and live vaccines. Increased risk of leucopenia with ACE inhibitors. Concurrent use may reduce the anticoagulant effect of vitamin K antagonists e.g. warfarin. Increased risk of myelosuppressive effects when used with drugs that inhibit TPMT (thiopurine methyltransferase) or xanthine oxidase e.g. olsalazine, allopurinol. Potentially Fatal: Increased risk of serious haematotoxicity or hepatotoxicity with leflunomide. Increased risk of bone marrow suppression with mycophenolate mofetil. Increased risk of infections and malignancies with efalizumab.

Buy Imruza 25 from Arogga

In Bangladesh, you can get the original Imruza 25. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Imruza 25 in Bangladesh?

The latest price of Imruza 25 in Bangladesh is 112৳. You can buy Imruza 25 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Imruza 25. Please consult your doctor.
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CONSULT YOUR DOCTOR
Imruza 25 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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CONSULT YOUR DOCTOR
Imruza 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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CONSULT YOUR DOCTOR
It is not known whether Imruza 25 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
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CAUTION
Imruza 25 should be used with caution in patients with kidney disease. Dose adjustment of Imruza 25 may be needed. Please consult your doctor. Use of Imruza 25 is not recommended in patients with serious kidney disease.
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CAUTION
Imruza 25 should be used with caution in patients with liver disease. Dose adjustment of Imruza 25 may be needed. Please consult your doctor. Use of Imruza 25 is not recommended in patients with severe liver disease. Regular monitoring of liver function tests is advisable while you are taking this medicine.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.