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Combocef 200
ACI Limited
Generic: Cefpodoxime + Clavulanic Acid
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Combocef 200. Please consult your doctor.
SAFE IF PRESCRIBED
Combocef 200 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Combocef 200 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Combocef 200 may cause side effects which could affect your ability to drive.
Combocef 200 may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive.
CAUTION
Combocef 200 should be used with caution in patients with severe kidney disease. Dose adjustment of Combocef 200 may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Combocef 200 in patients with liver disease. Please consult your doctor.
Medicine Overview of Combocef 200mg+125mg Tablet
Introduction
Combocef 200 is a combination of two medicines. It is prescribed to treat respiratory tract infections. It treats the infection and prevents further growth and spread of the microorganisms. Combocef 200 is a prescription medicine. It is advised to take it as per the prescription. It can be taken with or without food, but it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment...
... Show moreUses of Combocef 200
- Respiratory tract infection
Side effects of Combocef 200
Common
- Nausea
- Diarrhea
- Stomach pain
- Headache
How to use Combocef 200
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combocef 200 may be taken with or without food, but it is better to take it at a fixed time.
How Combocef 200 works
Combocef 200 is a combination of two medicines: Cefpodoxime Proxetil and Clavulanic Acid. Cefpodoxime Proxetil is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefpodoxime Proxetil against bacteria.
Quick Tips
- You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
- Take it with food and plenty of fluids to avoid an upset stomach.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect. Taking probiotics along with Cepodem XP 325 Tablet may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking Cepodem XP 325 Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
Brief Description
Indication
Pharyngitis, Acute otitis media, Community-acquired pneumonia, Sinusitis, UTI, Cystitis, Gonorrhea, Skin and skin structure infections, Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Acute bacterial exacerbation of chronic bronchitis, Enteric fever
Administration
Should be taken with food. Take after meals.
Adult Dose
Acute Bronchitis & Acute Exacerbations of Chronic Bronchitis, Acute Maxillary Sinusitis
200 mg PO q12hr for 10 days
Acute Community-Acquired Pneumonia
200 mg PO q12hr for 14 days
Pharyngitis/Tonsillitis
100 mg PO q12hr for 5-10 days
Skin/Skin Structure Infections
200-400 mg PO q12hr for 7-14 days
Uncomplicated gonorrhoea
200 mg as a single dose
Uncomplicated Urinary Tract Infections
100 mg PO q12hr for 7-14 days
Complicated urinary tract infections
200 mg PO 12 hourly for 7 days
Hepatic impairment
Dosage adjustment not necessary
Child Dose
Child : PO 10 mg/kg/day, max 400 mg/day q12h
6 months - 2 years : 40 mg every 12 hours
3 - 8 years : 80 mg every 12 hours
over 9 years : 100 mg every 12 hours
Renal Dose
Renal impairment: Patients on haemodialysis: Dose should be given after each dialysis session.
CrCl (ml/min) Dosage Recommendation
10-39 Increase dosing intervals to 24 hrly.
<10 Increase dosing intervals to 48 hrly.
Contraindication
Hypersensitivity.
Mode of Action
Cefpodoxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Addition of clavulanate inhibits beta-lactamase-producing bacteria; Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate Cefpodoxime by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with Cefpodoxime extends the antibacterial spectrum of Cefpodoxime to include many bacteria normally resistant to Cefpodoxime and other penicillins and cephalosporins.
Precaution
History of allergy to penicillin; severe renal impairment; pregnancy and lactation.
Lactation: Drug excreted in breast milk in low concentrations; not recommended
Side Effect
>10%
Diarrhea in infants and toddlers (15.4%),Diaper rash (12.1%)
1-10%
Diarrhea (7.4%),Nausea (3.8%),Vaginal infection (3.1%),Vomiting (1.1-2.1%),Abdominal pain (1.6%),Rash (1.4%),Headache (1.1%)
Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.
Interaction
Antacids or H2-blockers may decrease the absorption of cefpodoxime. Reduced renal excretion w/ probenecid.
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