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Comtan 200 mg

Tablet-(200mg)
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Nevian Lifescience PLC

Generic: Entacapone

30 Tablets (1 Box)
৳ 77.46
৳ 82.50
6% OFF

Medicine Overview of Comtan 200 mg 200mg Tablet

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Introduction

Comtan 200 mg is a prescription medicine used in the treatment of Parkinson's disease. This medicine helps to treat excessive shaking by slowing down the body movements. It works by increasing the amount of dopamine, a chemical messenger that is needed to control the abnormal movements. Comtan 200 mg has no antiparkinsonian effect on its own. It is used in combination with carbidopa/levodopa. It helps to treat wearing-off symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control. It may be taken with or without food, preferably at bedtime. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor. If you have missed a dose, take it as soon as you remember it. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your condition. Your doctor may advise for periodic skin examination as it can cause melanoma. Some common side effects of this medicine include nausea, vomiting, fatigue, confusion, constipation, insomnia(difficulty sleeping), nightmares, and increased sweating. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is common to have diarrhea with this medicine, so drink plenty of fluids and watch for weight loss. Inform your doctor if you develop any unusual changes in mood, an abnormally high sex drive, and hallucinations. It may cause your urine to change in a brownish-orange color but it is not harmful and usually resolves once treatment is completed. Please consult your doctor if these side effects worry you or do not go away.

Uses of Comtan 200 mg

  • Parkinson's disease

Side effects of Comtan 200 mg

Common
  • Nausea
  • Vomiting
  • Fatigue
  • Confusion
  • Constipation
  • Insomnia (difficulty in sleeping)
  • Nightmare
  • Hallucination
  • Increased sweating
  • Fall
  • Urine discoloration
  • Dizziness
  • Diarrhea
  • Muscle coordination impaired
  • Ischemic heart disease
  • Heart attack
  • Abdominal pain
  • Dryness in mouth

How to use Comtan 200 mg

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comtan 200 mg may be taken with or without food, but it is better to take it at a fixed time.

How Comtan 200 mg works

Comtan 200 mg is a selective reversible inhibitor which is given in combination with levodopa. It works by inhibiting a chemical messenger [catechol-O-methyl transferase (COMT)] which in turn helps in increasing the amount of dopamine (chemical messenger) in the brain. Thus, an adequate amount of dopamine in the brain helps to coordinate body movements. This is how it works to control symptoms of Parkinson's disease.

What if you forget to take Comtan 200 mg?

If you miss a dose of Comtan 200 mg, skip it and continue with your normal schedule. Do not double the dose.

Quick Tips

  • You have been prescribed Comtan 200 mg to enhance the effectiveness of levodopa for treatment of Parkinson's disease.
  • It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
  • Talk to your doctor in case you develop hallucinations or other changes in your behavior.
  • It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
  • Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
  • Do not stop taking the medication suddenly without talking to your doctor.

Brief Description

Indication

Parkinson's disease

Administration

May be taken with or without food.

Adult Dose

Oral Adjunct to levodopa treatment in Parkinson's disease Adult: 200 mg w/ each levodopa/dopa decarboxylase inhibitor dose. Max: 200 mg 10 times daily (2,000 mg daily). Hepatic Impairment Safety and efficacy not established

Renal Dose

Renal Impairment Dose adjustment not necessary

Contraindication

History of neuroleptic malignant syndrome and nontraumatic rhabdomyolysis. Phaeochromocytoma. Hepatic impairment.

Mode of Action

Entacapone is a selective, reversible, peripheral inhibitor of COMT, an enzyme involved in the metabolism of dopamine and levodopa. It is used in patients with Parkinson's disease and "end-of-dose" motor fluctuations that cannot be stabilised on levodopa combinations alone.

Precaution

Levodopa-induced orthostatic hypotension may be aggravated. Abrupt withdrawal. Concomitant use with a selective MAO-A and MAO-B inhibitor, or concomitant use with a selective MAO-A plus a selective MAO-B inhibitor. Biliary obstruction. Impairs ability to drive and operate machinery. Pregnancy and lactation. Children and elderly. Lactation: excretion in milk unknown; use with caution

Side Effect

>10% Dyskinesia (25%),Nausea (14%),Diarrhea (10%),Hyperkinesia (10%),Urine discoloration (10%) 1-10% Hypokinesia (9%),Dizziness (8%),Abdominal pain (8%),Fatigue (6%),Constipation (6%),Back pain (4%),Vomiting (4%),Dry mouth (3%),Dyspnea (3%),Increased sweating (2%),Back pain (2%),Anxiety (2%),Somnolence (2%),Dyspepsia (2%),Flatulence (2%),Purpura (2%),Asthenia (2%),Hallucinations (1-4%),Taste perversion (1%),Agitation (1%),Gastritis (1%),Bacterial infection (1%) Frequency Not Defined Insomnia,Postural hypotension,Confusion,Dopaminergic side affects due to increased dopamine levels Rare: rhabdomyolysis, retroperitoneal fibrosis

Pregnancy Category Note

Pregnancy Category: C Lactation: excretion in milk unknown; use with caution

Interaction

Drugs metabolised by COMT e.g. adrenaline, apomorphine, dobutamine, dopamine, isoprenaline, methyldopa, noradrenaline and remiterol. Iron preparations and levodopa. Avoid ethanol.

Buy Comtan 200 mg from Arogga

In Bangladesh, you can get the original Comtan 200 mg. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Comtan 200 mg in Bangladesh?

The latest price of Comtan 200 mg in Bangladesh is 77.46৳. You can buy Comtan 200 mg at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Comtan 200 mg may cause excessive drowsiness with alcohol.
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CONSULT YOUR DOCTOR
Comtan 200 mg may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
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CONSULT YOUR DOCTOR
Comtan 200 mg is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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CAUTION
Comtan 200 mg may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
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SAFE IF PRESCRIBED
Comtan 200 mg is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Comtan 200 mg may not be needed in these patients. Please consult your doctor.
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UNSAFE
Comtan 200 mg is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.