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Contine CR 250
Aristopharma Limited
Generic: Theophylline
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Contine CR 250.
CONSULT YOUR DOCTOR
Contine CR 250 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Contine CR 250 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Avoiding breastfeeding for 2-4 hours after Contine CR 250 can further decrease the exposure of medicine to the baby.
SAFE
Contine CR 250 does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Contine CR 250 is safe to use in patients with kidney disease. No dose adjustment of Contine CR 250 is recommended.
CAUTION
Contine CR 250 should be used with caution in patients with liver disease. Dose adjustment of Contine CR 250 may be needed. Please consult your doctor.
Medicine Overview of Contine CR 250mg Tablet
Introduction
Contine CR 250 is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe. Contine CR 250 can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve...
... Show moreUses of Contine CR 250
- Chronic obstructive pulmonary disease (COPD)
- Asthma
Side effects of Contine CR 250
Common
- Upset stomach
- Vomiting
- Headache
- Nausea
- Restlessness
How to use Contine CR 250
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Contine CR 250 is to be taken with food.
How Contine CR 250 works
Contine CR 250 is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.
Quick Tips
- You have been prescribed OD PHYLLIN 600 MG TABLET for prevention and treatment of asthma and chronic obstructive pulmonary disease (COPD).
- It should be taken at the same time each day, preferably in the evening after food.
- It does not work right away and should not be used to relieve sudden breathing problems. Always keep a fast-acting (rescue) inhaler with you.
- Your doctor may take regular blood test to monitor potassium level and the level of this medicine in your body.
- Notify your doctor if you have ever been diagnosed with kidney, liver or heart disease, or if you have a smoking history. Your dose may need to be adjusted.
- Do not discontinue use without consulting your doctor, even if you feel better.
Brief Description
Indication
Asthma, Chronic obstructive pulmonary disease, Bronchospasm, Apnoea of prematurity
Administration
May be taken with or without food, at least 1 hour before or 2 hour after meal.
Adult Dose
Oral Acute Asthma Loading Dose: 5 mg/kg loading dose (patient not receiving theophylline or aminophylline). Maintenance of Asthma, COPD General Dosing Recommendations The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Maintenance Dose: 10-16/mg/kg/day Adult: Starting Dose: 300-400mg/day once or twice daily. After 3 days if tolerated, increase dose to 400-600mg/day once or twice dialy. Max: 600mg/day Adult: As SR/CR Cap or Tab, 200/300 mg: One tablet/capsule every 12 hourly. As 400mg tablet/capsule One tab/cap...
... Show moreChild Dose
Oral Acute Asthma Loading Dose: 5 mg/kg loading dose If no theophylline has been administered in the previous 24 hours 2.5 mg/kg loading dose If theophylline has been administered in the previous 24 hours Maintenance of Asthma General Dosing Recommendations The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Maintenance Dose: Child 1.5-6 months: 10 mg/kg/day PO in divided doses 6-12 months: 12-18 mg/kg/day PO in divided doses 1-9 years: 8 mg/kg PO (extended release)...
... Show moreContraindication
Hypersensitivity to xanthine derivatives, porphyria.
Mode of Action
Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion.
Precaution
Patient w/ peptic ulceration, hyperthyroidism, DM, glaucoma, severe hypoxemia, epilepsy, HTN, heart failure, cardiac arrhythmias or other CV disease, acute febrile illness, COPD, cor pulmonale; smokers. Hepatic or renal impairment. Elderly and childn. Pregnancy and lactation. Monitoring Parameters Monitor heart rate, CNS effects, resp rate, arterial or capillary blood gases, theophylline levels.
Lactation: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants; serious adverse effects in infant are unlikely unless mother has toxic serum theophylline concentration
Side Effect
Nausea, vomiting, epigastric pain, abdominal cramps, anorexia, diarrhoea, haematemesis; headache, irritability, restlessness, nervousness, insomnia, dizziness, reflex hyperexcitability, seizures; palpitations, sinus tachycardia, extrasystoles, increased pulse rate, flushing, circulatory failure, hypotension, ventricular arrhythmias; transient increase in urinary frequency, dehydration, twitching of fingers and hands, tachypnoea, elevated serum AST concentrations.
Potentially Fatal: Convulsions, cardiac arrhythmias, severe hypotension or cardiac arrest.
Interaction
Increased plasma concentrations w/ allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibiotics, quinolones, OCs, tiabendazole, viloxazine, Ca channel blockers. Reduced plasma concentrations w/ phenytoin and other antiepileptics, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, carbamazepine. Enhanced lithium excretion. May potentiate hypokalaemia w/ corticosteroids and diuretics. Risk of synergistic toxicity when given w/ halothane or ketamine. May antagonise effects of adenosine and competitive neuromuscular blockers. Increased bronchospasm w/ β-blockers.
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