12-24 Hours
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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Covan does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Covan may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Covan is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Covan does not usually affect your ability to drive.
CAUTION
Covan should be used with caution in patients with kidney disease. Dose adjustment of Covan may be needed. Please consult your doctor.
Regular monitoring of kidney function test and some blood tests is advised while you are taking this medicine.
CONSULT YOUR DOCTOR
There is limited information available on the use of Covan in patients with liver disease. Please consult your doctor.
Medicine Overview of Covan 500mg Injection
Introduction
Covan is an antibiotic used in the treatment of severe bacterial infections in hospitalized patients. It is effective against infections of the respiratory tract (e.g. pneumonia), urinary tract, skin and soft tissues, bones and joints, heart, blood and others. Covan is also used for the prevention of infection in some high-risk patients undergoing surgical procedures. It works by stopping the growth of bacteria and is useful for treating adults as well as children. It is a narrow-spectrum antibiotic that only covers the gram-positive type of bacteria. This medicine is administered slowly by a drip (infusion) into a vein, under the...
... Show moreUses of Covan
- Severe bacterial infections
Side effects of Covan
Common
- Breathlessness
- Decreased blood pressure
- Wheezing
- Renal injury
- Flushing (sense of warmth in the face, ears, neck and trunk)
How to use Covan
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Covan works
Covan is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
- You have been prescribed Covan to treat serious bacterial infections of the heart, blood, bones, and soft tissues.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- It should be taken slowly via a drip. Fast infusion can lead to reactions such as low blood pressure, wheezing, shortness of breath or itching.
- Your doctor may regularly monitor your kidney function and your hearing while you are taking this medicine.
- Your doctor may get regular blood tests done to check the level of this medicine in your blood.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Septicaemia, Soft tissue infections, Osteomyelitis, Enterocolitis, Colitis, Serious staphylococcal or other Gm +ve infections, Bacterial endocarditis
Administration
IV Preparation
Add 10 mL of SWI to 500-mg vial and 20 mL of SWI to 1-g vial to yield 50 mg/mL solution; further dilution is required, depending on method of administration
Intermittent infusion: Dilute 500 mg with ?100 mL of diluent and 1 g with ?200 mL of diluent (NS or D5W)
Continuous infusion: Dilute in sufficient amount to permit infusion over 24 hours
IV Administration
Intermittent (preferred): Administer over 60 minutes; not to exceed 10 mg/min
Continuous: Administer over 24 hours
Adult Dose
Intravenous
Severe staphylococcal or other Gram-positive infections, Endocarditis
Adult: 500 mg 6 hrly, infused over at least 60 min or 1 g 12 hrly, infused over at least 100 min.
Elderly: Dosage adjustment needed.
Child Dose
Intravenous
Children
Severe staphylococcal or other Gram-positive infections, Endocarditis
1 month: 10 mg/kg/day IV divided q6hr; individual dose not to exceed 1 g
Renal Dose
Renal impairment: Patient on intermittent haemodialysis: Loading dose: 15-25 mg/kg on day 1, followed by 5-10 mg/kg maintenance dose after each dialysis run. Anuric patient (w/o kidney function) on dialysis: Initially, 15 mg/kg. Maintenance: 1.9 mg/kg 24 hrly.
CrCl (ml/min) Dosage Recommendation
50 Initially, 15-20 mg/kg/dose (usual: 750-1,500 mg) 8-12 hrly.
Contraindication
Hypersensitivity to the drug; history of impaired hearing; IM administration.
Mode of Action
Vancomycin binds tightly to D-alanyl-D-alanine portion cell wall precursor causing blockage of glycopeptide polymerisation which produces immediate inhibition of cell wall synthesis and secondary damage to the cytoplasmic membrane.
Precaution
Patient w/ allergic reaction to teicoplanin, previous hearing loss, inflammatory bowel disease. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Determine regularly serial tests of auditory function and serum or blood vancomycin concentrations during treatment. Periodic urinalysis and renal function tests. Monitor leukocyte count in prolonged therapy.
Lactation: Drug enters breast milk; not recommended
Side Effect
>10%
Erythematous rash on face and upper body (red neck or red man syndrome; related to infusion rate),Hypotension accompanied by flushing
1-10%
Chills,Drug fever,Eosinophilia,Rash,Reversible neutropenia,Phlebitis
<1%
Nephrotoxicity,Ototoxicity (especially with large doses),Stevens-Johnson syndrome,Thrombocytopenia,Vasculitis
Potentially Fatal: Stevens-Johnson syndrome; toxic epidermal necrolysis, blood dyscrasias such as neutropenia or thrombocytopenia.
Interaction
General anaesth may enhance the adverse effects of vancomycin. Increased risk of ototoxicity and nephrotoxicity w/ aminoglycosides, polymyxins, ciclosporin, cisplatin and loop diuretics. Increased potential of neuromuscular blockade w/ suxamethonium or vecuronium.
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