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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Vinorelbine. Please consult your doctor.
CONSULT YOUR DOCTOR
Vinorelbine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Vinorelbine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Vinorelbine does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Vinorelbine is safe to use in patients with kidney disease. No dose adjustment of Vinorelbine is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CAUTION
Vinorelbine should be used with caution in patients with liver disease. Dose adjustment of Vinorelbine may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised while these patients are taking this medicine.
Medicine Overview of Vinorelbine 30mg Tablet
Introduction
Vinorelbine is an anti-cancer medication used in the treatment of breast cancer and non-small cell lung cancer. It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel...
... Show moreUses of Vinorelbine
- Breast cancer
- Non-small cell lung cancer
Side effects of Vinorelbine
Common
- Nausea
- Vomiting
- Weakness
- Fatigue
- Hair loss
- Low blood platelets
- Increased liver enzymes
- Fever
- Anemia (low number of red blood cells)
- Bleeding
- Constipation
How to use Vinorelbine
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Vinorelbine works
Vinorelbine blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.
Quick Tips
- Inform your doctor if you have a history of heart problems, vascular problems or low production of blood cells from the bone marrow (myelosupression); liver problems or have had radiotherapy around the liver.
- Do not take live or attenuated vaccines during therapy and avoid contact with people who receive them.
- Use two methods of contraception while on this therapy and 3 months after it to avoid pregnancy.
- Men should not father a child while on this therapy and 3 months post it. They should also seek guidance and counselling on sperm conservation before taking this therapy.
- Avoid contact with skin, eyes or mucosa as vinorelbine may cause irritation. Thoroughly wash the skin area, in case of skin contact with the medicine.
- Take vinorelbine preferably with a light meal to reduce nausea. Soft capsule gels of vinorelbine should not be taken with hot fluids, as the medicine may quickly dissolve.
- Vinorelbine is not recommended in children below 18 years.
Brief Description
Indication
Breast cancer, Ovarian cancer, Cervical cancer, Non-small cell lung cancer
Administration
IV Preparation
May be diluted in syringe or bag
Syringe: dilute to 1.5-3 mg/mL in NS or D5W
IV Bag: dilute to 0.5-2 mg/mL in NS, 1/2NS, D5W, D5/½NS, LR or Ringer's
IV Administration
Administer IV over 6-10 min through sidearm of free-flowing IV closest to IV bag
Then flush with 75-125 mL of one of the IV fluids
Adult Dose
Oral Non-small cell lung cancer Adult: 60 mg/m2once wkly for 3 wk, may increase subsequently to 80 mg/m2 once wkly. If neutrophil count is 75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Intravenous Non-small cell lung cancer Adult: As single agent: 30 mg/m2 wkly as infusion over 20-30 minutes (after diluting in 125 ml normal saline or glucose 5%) or as slow bolus over 5-10 minutes (after diluting in 20-50 ml normal saline or glucose 5%). Delay subsequent...
... Show moreContraindication
Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.
Mode of Action
Vinorelbine, a semisynthetic vinblastine derivative, binds to tubulin and inhibits microtubule formation. This disrupts the formation of the mitotic spindle thereby arresting the cell at metaphase.
Precaution
Hepatic impairment. Compromised bone marrow reserve due to prior irradiation or chemotherapy; recovering marrow function from the effects of previous chemotherapy. Prior radiation therapy; past history or pre-existing neuropathy. CBC with differentials to be monitored prior to admin of subsequent doses. Delay subsequent doses, if neutrophil count < 2000 cells/mm3. Each admin to be followed by at least 250 ml of normal saline to flush the vein. Avoid extravasation. If extravasation occurs, stop infusion immediately, and flush the vein with normal saline solution; admin the remaining solution in another vein. Do not father a child during and up to six...
... Show moreSide Effect
>10%
Leukopenia (92%),Granulocytopenia (90%),Anemia (83%),Elev AST (67%),Nausea (44%),Asthenia (36%),Constipation (35%),Fatigue (27%),Peripheral neuropathy (25%),Vomiting (20%),Anorexia (20%),Stomatitis (20%),Alopecia (12%)
1-10%
Dyspnea (7%),Chest pain (5%),Rash (5%),SOB (3%),Hemorrhagic cystitis (1%),SIADH (1%)
Interaction
Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.
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