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Vinorelbine

Tablet-(30mg)
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ZAS Corporation

Generic: Vinorelbine

1 Tablet
৳ 5226.75
৳ 5750
9% OFF

Medicine Overview of Vinorelbine 30mg Tablet

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Introduction

Vinorelbine is an anti-cancer medication used in the treatment of breast cancer and non-small cell lung cancer. It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, weakness, fatigue, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Men are advised to seek guidance and counselling on sperm conservation before taking this therapy.

Uses of Vinorelbine

  • Breast cancer
  • Non-small cell lung cancer

Side effects of Vinorelbine

Common
  • Nausea
  • Vomiting
  • Weakness
  • Fatigue
  • Hair loss
  • Low blood platelets
  • Increased liver enzymes
  • Fever
  • Anemia (low number of red blood cells)
  • Bleeding
  • Constipation

How to use Vinorelbine

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Vinorelbine works

Vinorelbine blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

Quick Tips

  • Inform your doctor if you have a history of heart problems, vascular problems or low production of blood cells from the bone marrow (myelosupression); liver problems or have had radiotherapy around the liver.
  • Do not take live or attenuated vaccines during therapy and avoid contact with people who receive them.
  • Use two methods of contraception while on this therapy and 3 months after it to avoid pregnancy.
  • Men should not father a child while on this therapy and 3 months post it. They should also seek guidance and counselling on sperm conservation before taking this therapy.
  • Avoid contact with skin, eyes or mucosa as vinorelbine may cause irritation. Thoroughly wash the skin area, in case of skin contact with the medicine.
  • Take vinorelbine preferably with a light meal to reduce nausea. Soft capsule gels of vinorelbine should not be taken with hot fluids, as the medicine may quickly dissolve.
  • Vinorelbine is not recommended in children below 18 years.

Brief Description

Indication

Breast cancer, Ovarian cancer, Cervical cancer, Non-small cell lung cancer

Administration

IV Preparation May be diluted in syringe or bag Syringe: dilute to 1.5-3 mg/mL in NS or D5W IV Bag: dilute to 0.5-2 mg/mL in NS, 1/2NS, D5W, D5/½NS, LR or Ringer's IV Administration Administer IV over 6-10 min through sidearm of free-flowing IV closest to IV bag Then flush with 75-125 mL of one of the IV fluids

Adult Dose

Oral Non-small cell lung cancer Adult: 60 mg/m2once wkly for 3 wk, may increase subsequently to 80 mg/m2 once wkly. If neutrophil count is < 500 cells/mm3 or between 500-1000 cells/mm3 on 2 separate occasions, keep dose at 60 mg/m2 for next 3 doses. Hepatic impairment: Massive liver metastases(>75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Intravenous Non-small cell lung cancer Adult: As single agent: 30 mg/m2 wkly as infusion over 20-30 minutes (after diluting in 125 ml normal saline or glucose 5%) or as slow bolus over 5-10 minutes (after diluting in 20-50 ml normal saline or glucose 5%). Delay subsequent doses if neutrophil count is <2000 cells/mm3 until recovery. As combination therapy with cisplatin: 25-30 mg/m2 every 7 days. Hepatic impairment: Massive liver metastases(>75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Cervical cancer Adult: 30 mg/m2/dose days 1 and 8 of a 21-day treatment cycle. Intravenous Breast cancer; Ovarian cancer Adult: 25 mg/m2/dose every 7 days. Hepatic impairment: Dose adjustments may be needed.

Contraindication

Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.

Mode of Action

Vinorelbine, a semisynthetic vinblastine derivative, binds to tubulin and inhibits microtubule formation. This disrupts the formation of the mitotic spindle thereby arresting the cell at metaphase.

Precaution

Hepatic impairment. Compromised bone marrow reserve due to prior irradiation or chemotherapy; recovering marrow function from the effects of previous chemotherapy. Prior radiation therapy; past history or pre-existing neuropathy. CBC with differentials to be monitored prior to admin of subsequent doses. Delay subsequent doses, if neutrophil count < 2000 cells/mm3. Each admin to be followed by at least 250 ml of normal saline to flush the vein. Avoid extravasation. If extravasation occurs, stop infusion immediately, and flush the vein with normal saline solution; admin the remaining solution in another vein. Do not father a child during and up to six mth after treatment and females of childbearing potential to use effective method of contraception during treatment and three mth thereafter. When admin orally, capsules must be swallowed whole with water and not chewed or sucked. Lactation: not known if excreted in breast milk; do not nurse

Side Effect

>10% Leukopenia (92%),Granulocytopenia (90%),Anemia (83%),Elev AST (67%),Nausea (44%),Asthenia (36%),Constipation (35%),Fatigue (27%),Peripheral neuropathy (25%),Vomiting (20%),Anorexia (20%),Stomatitis (20%),Alopecia (12%) 1-10% Dyspnea (7%),Chest pain (5%),Rash (5%),SOB (3%),Hemorrhagic cystitis (1%),SIADH (1%)

Interaction

Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.

Buy Vinorelbine from Arogga

In Bangladesh, you can get the original Vinorelbine. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Vinorelbine in Bangladesh?

The latest price of Vinorelbine in Bangladesh is 5226.75৳. You can buy Vinorelbine at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Vinorelbine. Please consult your doctor.
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CONSULT YOUR DOCTOR
Vinorelbine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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UNSAFE
Vinorelbine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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SAFE
Vinorelbine does not usually affect your ability to drive.
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SAFE IF PRESCRIBED
Vinorelbine is safe to use in patients with kidney disease. No dose adjustment of Vinorelbine is recommended. However, talk to your doctor if you have any underlying kidney disease.
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CAUTION
Vinorelbine should be used with caution in patients with liver disease. Dose adjustment of Vinorelbine may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised while these patients are taking this medicine.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.