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Cytabin
Beacon Pharmaceuticals PLC
Generic: Cytarabine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Cytabin. Please consult your doctor.
CONSULT YOUR DOCTOR
Cytabin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Cytabin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Cytabin may cause side effects which could affect your ability to drive.
SAFE IF PRESCRIBED
Cytabin is safe to use in patients with kidney disease. No dose adjustment of Cytabin is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CONSULT YOUR DOCTOR
There is limited information available on the use of Cytabin in patients with liver disease. Please consult your doctor.
Because of the limited information, a cautious use of Cytabin is recommended in patients with liver disease.
Medicine Overview of Cytabin 100mg/ml Injection
Introduction
Cytabin is used to treat some kinds of cancers of blood. It may be also used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. Cytabin is given as an injection into the vein or under skin by the healthcare professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in...
... Show moreUses of Cytabin
- Blood cancer
Side effects of Cytabin
Common
- Rash
- Skin ulcer
- Nausea
- Vomiting
- Hair loss
- Abdominal pain
- Anal ulcers
- Anemia (low number of red blood cells)
- Decreased white blood cell count
- Fever
- Infection
- Abnormal liver function
- Low blood platelets
- Mouth ulcer
- Pneumonia
- Sepsis
- Mouth sore
- Stomatitis (Inflammation of the mouth)
How to use Cytabin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Cytabin works
Cytabin interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks. It prevents the cancer cells from growing and multiplying.
Quick Tips
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Brief Description
Indication
Acute myeloid leukaemia, acute lymphocytic leukaemia (ALL), lymphomas, Leukaemic meningitis
Administration
IV Administration Rapid IV, infusion over 1-3 hr, or SC intrathecal Has been administered by IM & continuous SC infusion IT: Patient should lie flat for 1 hour after lumbar puncture Liposomal: To reduce incidence of arachnoiditis, administer dexamethasone concurrently IV Preparation Reconstitute vials in BWI containing benzyl alcohol 0.945% as follows (CAUTION: Do not use benzyl alcohol for intrathecal inj) 100 mg vial: add 5 mL diluent to 20 mg/mL 500 mg vial: add 10 mL diluent to 50 mg/mL 1 g vial: add 10 mL diluent to 100 mg/mL 2 g vial: add 20 mL diluent to 100...
... Show moreAdult Dose
Acute Nonlymphocytic Leukemia IV administration for remission induction 100-200 mg/sq.meter/day for 5-10 days; begin second course in 2-4 weeks after initial therapy if necessary OR 100 mg/sq.meter for 7 days OR 100 mg/sq.meter/dose q12hr for 7 days Intrathecal (IT) administration for remission induction 5-75 mg/sq.meter q2-7Days until CNS findings normalize IV administration for remission maintenance 70-200 mg/sq.meter/day for 2-5 days at monthly intervals IM administration for remission maintenance 1-1.5 mg/kg single dose for maintenance at 1- 4 week intervals Meningeal Leukemia IT administration 30 mg/sq.meter intrathecal (IT) q4Days until CSF findings normal plus one additional dose Refractory Leukemia IV administration...
... Show moreContraindication
Hypersensitivity; pregnancy and lactation.
Mode of Action
Cytarabine acts by interfering with DNA synthesis specifically at the S-phase of the cell cycle. It is a potent myelosuppressant and requires careful haematological monitoring during its use. It also has antiviral property.
Precaution
Hepatic and renal dysfunction, severe infections, preexisting drug-induced bone marrow suppression. Monitor WBC, platelet counts and blood uric acid frequently. Assess renal and hepatic function periodically.
Lactation: not known if excreted in breast milk, avoid
Side Effect
1-10%
Anorexia,Nausea,Vomiting,Diarrhea,Oral/anal inflammation,Thrombophlebitis,Bleeding,Myelosuppression,Rash,Fever,Hepatic dysfunction
Frequency Not Defined
Headache,Neuropathy,Chest pain,Pericarditis,Pneumonia,Anemia,Bleeding,Leukopenia,Thrombocytopenia,Kidney disease,Infectious disease,Sepsis,"Cytarabine syndrome": fever, myalgia, bone pain, rash, conjunctivitis, malaise,Skin ulcers,Cellulitis,Urinary retention,Neuritis,Jaundice,Anaphylaxis
Potentially Fatal: Convulsions. Cerebellar dysfunction, respiratory distress syndrome, GI perforation, bone marrow suppression.
Pregnancy Category Note
Pregnancy Category: D
Lactation: not known if excreted in breast milk, avoid
Interaction
May reduce efficacy of gentamicin, digoxin and flucytosine.
Potentially Fatal: Potentiates bone marrow depression with radiotherapy and other myelotoxic drugs.
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