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Glifo-M 12.5/ 500
The ACME Laboratories Ltd.
Generic: Empagliflozin + Metformin Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume Glifo-M 12.5/ 500 with alcohol.
UNSAFE
Glifo-M 12.5/ 500 should not be used during pregnancy.
UNSAFE
Glifo-M 12.5/ 500 should not be used during breastfeeding.
CAUTION
Glifo-M 12.5/ 500 may cause dizziness or orthostatic hypotension (low blood pressure when standing up), which can impair ability to drive.
CONSULT YOUR DOCTOR
It is important to talk to your doctor about the risks and benefits of taking Glifo-M 12.5/ 500 before starting treatment. Glifo-M 12.5/ 500 should not be given to patients with serious kidney disease.
CAUTION
Glifo-M 12.5/ 500 may not be suitable for patients with severe liver impairment.
Medicine Overview of Glifo-M 12.5/ 500 12.5mg+500mg Tablet
Introduction
Glifo-M 12.5/ 500 is a combination of empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor and metformin hydrochloride, a biguanide, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both empagliflozin and metformin hydrochloride is appropriate.Glifo-M 12.5/ 500 is indicated to reduce the risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease. However, the effectiveness of Glifo-M 12.5/ 500 on reducing the risk of cardiovascular death in adults with type 2 diabetes mellitus and cardiovascular disease has not been established.
Uses of Glifo-M 12.5/ 500
Glifo-M 12.5/ 500 use as a treatment of adults with type 2 diabetes mellitus.
Side effects of Glifo-M 12.5/ 500
- Nausea
- Vomiting
- Diarrhea
- Headaches
- Dizziness
- Fatigue
- Abdominal pain
- Increased urination
- Weight loss
How to use Glifo-M 12.5/ 500
Take Glifo-M 12.5/ 500 in the dose and duration prescribed by your doctor. Swallow it whole. Don't chew, crush, or break it. Glifo-M 12.5/ 500 should be taken with food.
How Glifo-M 12.5/ 500 works
By blocking SGLT2,Glifo-M 12.5/ 500 prevents glucose from being reabsorbed and allows it to be excreted in the urine.Also work by decreasing the production of glucose in the liver and increasing the sensitivity of cells to insulin and lowers blood sugar levels.
What if you forget to take Glifo-M 12.5/ 500 ?
If you forget to take yourGlifo-M 12.5/ 500 , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.
Brief Description
Indication
Indicated for the treatment of adults with Type 2 Dabetes Mellitus as an adjunct to diet and exercise.
Administration
The dosage should be adjusted according to effectiveness and tolerability. Take this combination twice a day, with meals. To reduce the gastrointestinal side effects associated with Metformin Hydrochloride, dose escalation should be gradual. The maximum recommended daily dose of Metformin Hydrochloride is 2000 mg, while Empagliflozin is 25 mg.
Adult Dose
The standard starting dose for empagliflozin + metformin hydrochloride is 5 mg of empagliflozin and 500 mg of metformin hydrochloride once daily.
The dose can be gradually increased to a maximum of 25 mg of empagliflozin and 2,000 mg of metformin hydrochloride per day.
Child Dose
The safety and efficacy of this medication in children under the age of 18 has not been established.
Renal Dose
Before starting this combination with a renally impaired patient, assess their renal function.In patients with an eGFR below 45 mL/min/1.73 m2 is contraindicated.
Contraindication
•Type 1 diabetes
•Diabetic ketoacidosis (DKA)
•Severe kidney disease (eGFR < 30 mL/min/1.73 m2)
•Severe liver disease
•Heart failure
•Active bladder infection
•Recent surgery or major trauma
•Hypersensitivity to empagliflozin or metformin hydrochloride History of lactic acidosis.
• History of urinary tract infections or genital yeast infections
•Risk of dehydration
•Elderly patients
Mode of Action
By blocking SGLT2, empagliflozin prevents glucose from being reabsorbed and allows it to be excreted in the urine and decreasing the production of glucose in the liver and increasing the sensitivity of cells to insulin .It work synergistically to lower blood sugar levels more effectively.
Precautions
Empagliflozin + metformin hydrochloride should not be used by individuals with -
• Type 1 diabetes.
• Diabetic ketoacidosis
• Severe kidney disease
• Severe liver diseases
• Heart failure.
• Active bladder infection.
• Recent surgery or significant trauma
Side Effect
Serious side effects:
• Diabetic ketoacidosis (DKA)
• Lactic acidosis
• Hypoglycemia (low blood sugar)
• Dehydration
• Urinary tract infections
• Female genital mycotic infections
• urticaria, dysuria
• Vaginal moniliasisia
Common side effects :
• Increased urination
• Thirst
• Dry mouth
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Fatigue
• Weight loss
Pregnancy & Lactation Category Note
Pregnancy:
It is s not recommended for use during pregnancy due to potential risk to a fetus especially during the second and third trimesters.
Lactation:
Empagliflozin is excreted in breast milk and may be harmful to the nursing infant. Metformin hydrochloride is also excreted in breast milk, but it is unclear whether it can harm a nursing infant.
Interaction
It may interact with other medications, including: •Insulin: Empagliflozin + metformin hydrochloride can increase the risk of hypoglycemia (low blood sugar) when used with insulin. •Sulfonylureas: Empagliflozin + metformin hydrochloride can also increase the risk of hypoglycemia when used with sulfonylureas, another type of medication used to treat type 2 diabetes. •Meglitinides: Empagliflozin + metformin hydrochloride can also increase the risk of hypoglycemia when used with meglitinides, another type of medication used to treat type 2 diabetes. •Thiazolidinediones: Empagliflozin + metformin hydrochloride may increase the risk of heart failure when used with thiazolidinediones, another type of medication used to treat...
... Show moreStorage Conditions
Store below 30°C temperature, protected from light & moisture. Keep out of the reach of children.
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