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Depram 25

Tablet-(25mg)
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Square Pharmaceuticals PLC.

Generic: Imipramine Hydrochloride

10 Tablets (1 Strip)
৳ 45
৳ 50
10% OFF
Alternative Brands For Depram 25

Medicine Overview of Depram 25mg Tablet

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Introduction

Depram 25 is known as a tricyclic antidepressant. It is used to treat depression and bedwetting in children of age 6 years and above. It is also effective in treating depression that is unresponsive to other treatments. Depram 25 works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is better to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed any dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor. Your dose may be modified or gradually decreased before stopping the medication. The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, difficulty in urination and constipation. Initially, this medicine may also cause a sudden drop in blood pressure, especially when you change positions. It may even cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. To lower the chances of dizziness, rise slowly if you have been sitting or lying down. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should be avoided as alcohol interacts with this medicine to cause serious health issues.

Uses of Depram 25

  • Depression
  • Bed-wetting

Side effects of Depram 25

Common
  • Increased heart rate
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Constipation
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)

How to use Depram 25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depram 25 may be taken with or without food, but it is better to take it at a fixed time.

How Depram 25 works

Depram 25 is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

What if you forget to take Depram 25?

If you miss a dose of Depram 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • Depram 25 is used for the treatment of depression and bedwetting in children.
  • The main dose should be taken at night as this medicine may produce drowsiness or sleepiness.
  • You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
  • Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine.
  • Do not drive or do anything that requires concentration until you know how this medicine affects you.
  • Do not stop taking the medication suddenly without talking to your doctor.

Brief Description

Indication

Depression, Nocturnal enuresis

Administration

May be taken with or without food.

Adult Dose

Oral Depression Adult: Initially, 75 mg in divided doses, may gradually increase to 150-200 mg daily as necessary. Max: 300 mg/day. May give in divided doses or single dose HS Maintenance dose: 50-100 mg PO qDay Elderly: 10 mg daily, may gradually increase to 30-50 mg daily. Hepatic impairment: Severe: Contraindicated.

Child Dose

Oral Nocturnal enuresis Child: 6-7 yr 20-25 kg: 25 mg; 8-11 yr 25-35 kg: 25-50 mg; >11yr 35-54 kg: 50-75 mg. Doses are given just before bedtime. Max treatment duration: 3 mth.

Contraindication

Any degree of heart block or cardiac arrhythmias, recent MI, porphyria, narrow-angle glaucoma, urine retention, mania. Severe hepatic impairment. Childn <6 yr. Concomitant use w/ MAOIs.

Mode of Action

Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors.

Precaution

Imipramine should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma. The sedative effect is increased when imipramine is taken with other central nervous system depressants, such as alcoholic beverages, sleeping medications, other sedatives, or antihistamines. Imipramine may increase heart rate and stress on the heart. It may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack, to take this drug or other antidepressants in the same pharmacological class. Older people and persons with a history of heart disease may develop heart arrhythmias, heart conduction abnormalities, congestive heart failure, heart attack, abnormally rapid heart rates and strokes. Until a therapeutic dosage has been determined, people starting imipramine should be closely watched for signs of suicide. The risk of suicide is increased when imipramine is taken in overdose or combined with alcohol. Manic episodes and the emergence of symptoms of pre-existing psychotic states have been reported when imipramine therapy is started. In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (<24 years) taking antidepressants for major depressive disorders and other psychiatric illnesses. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy and dosage adjustments Lactation: Distributed in breast milk; do not nurse (AAP states effect on nursing infants is unknown but may be of concern)

Side Effect

Orthostatic hypotension, HTN, tachycardia, palpitation, MI, arrhythmias, heart block, ECG changes, precipitation of CHF, stroke; confusional states (esp in elderly) w/ hallucinations, disorientation, delusions; anxiety, restlessness, agitation, insomnia and nightmares, hypomania, exacerbation of psychosis; numbness, tingling, paraesthesias of extremities; incoordination, ataxia, tremors, peripheral neuropathy, extrapyramidal symptoms, seizures, altered EEG patterns, tinnitus; dry mouth; rarely, associated SL adenitis; blurred vision, accommodation disturbances, mydriasis, constipation, paralytic ileus, urinary retention, delayed micturition, dilated urinary tract; skin rash, petechiae, urticaria, itching, photosensitization, oedema, drug fever; bone marrow depression, agranulocytosis; eosinophilia, purpura, thrombocytopenia; nausea and vomiting, anorexia, epigastric distress, diarrhoea, peculiar taste, stomatitis, abdominal cramps, black tongue; gynaecomastia (male), breast enlargement and galactorrhea (female), increased/decreased libido, impotence, testicular swelling, increased/decreased blood sugar levels, inappropriate antidiuretic hormone secretion syndrome; jaundice, altered liver function, wt gain/loss, perspiration, flushing, urinary frequency, drowsiness, dizziness, weakness and fatigue, headache, parotid swelling, alopecia, proneness to falling.

Interaction

Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide. Reduced plasma levels with barbiturates, phenytoin. May increase effects of anticholinergic drugs. Severe orthostatic hypotension with altretamine. Causes drowsiness and impaired performance in combination with alcohol. Potentially Fatal: Severe hypertension with adrenaline, noradrenaline and methylphenidate. Reduces hypotensive effects of guanethidine, bethanidine, debrisoquine, bretylium, methyldopa and clonidine. Possible serotonin syndrome with MAOIs, separate admin by 3 wk.

Buy Depram 25 from Arogga

In Bangladesh, you can get the original Depram 25. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Depram 25 in Bangladesh?

The latest price of Depram 25 in Bangladesh is 45৳. You can buy Depram 25 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Depram 25 may cause excessive drowsiness with alcohol.
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CONSULT YOUR DOCTOR
Depram 25 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
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CONSULT YOUR DOCTOR
Depram 25 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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UNSAFE
Depram 25 may cause side effects which could affect your ability to drive. As Depram 25 may impair your alertness or cause drowsiness or blurred vision, and this may affect your ability to drive.
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CAUTION
Depram 25 should be used with caution in patients with kidney disease. Dose adjustment of Depram 25 may be needed. Please consult your doctor.
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CAUTION
Depram 25 should be used with caution in patients with liver disease. Dose adjustment of Depram 25 may be needed. Please consult your doctor. Regular monitoring of liver function tests is recommended while you are taking this medicine.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.