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Danazol
The Ibn Sina Pharmaceutical Ind. Ltd.
Generic: Danazol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Danazol.
UNSAFE
Danazol is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Danazol is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Danazol may cause side effects which could affect your ability to drive.
Danazol may cause some side effects such as dizziness, a spinning feeling, and changes in eyesight. This may affect your driving ability.
CAUTION
Danazol should be used with caution in patients with kidney disease. Dose adjustment of Danazol may be needed. Please consult your doctor.
Use of Danazol may not be advised in patients with severe kidney disease.
CAUTION
Danazol should be used with caution in patients with liver disease. Dose adjustment of Danazol may be needed. Please consult your doctor.
Use of Danazol is not recommended in patients with the severe liver disease. Regular monitoring of liver function tests is advised while you are taking this medicine.
Medicine Overview of Danazol 200mg Capsule
Introduction
Danazol is used to treat various menstrual problems including painful or irregular periods, premenstrual tension (PMT), Benign fibrocystic breast disease (painful breast disease) and a condition called endometriosis. Danazol can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should take this medicine for as...
... Show moreUses of Danazol
- Heavy menstrual bleeding
- Endometriosis
- Benign fibrocystic breast disease
Side effects of Danazol
Common
- Hoarseness of voice
- Hair loss
- Weight gain
- Acne
- Abnormal hair growth on a women face and body
- Voice change
- Itchy scalp
- Swelling
- Sore throat
How to use Danazol
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Danazol may be taken with or without food, but it is better to take it at a fixed time.
How Danazol works
Danazol modulates the action of certain female hormones in the body.
What if you forget to take Danazol?
If you miss a dose of Danazol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Danazol helps treat endometriosis and heavy or painful periods.
- It may also be used to relieve severe breast pain and tenderness in benign fibrocystic breast disease.
- Use effective measures to avoid pregnancy during treatment with this medicine as it can be harmful to an unborn baby.
- Do not drink alcohol during treatment with this medicine as it can make you feel sick or short of breath.
- Inform your doctor immediately if you experience symptoms such as hair loss, marked increase in facial or body hair, voice change, altered vision, severe headache and vomiting, stabbing pains and/or unusual swelling in one leg, sudden breathlessness or sudden chest pain, while taking this medicine.
Brief Description
Indication
Endometriosis, Benign breast disorders, Gynaecomastia, Hereditary angioedema, Menorrhagia.
Administration
May be taken with or without food. Take consistently either always w/ or always w/o meals.
Adult Dose
Oral Endometriosis Adult: 200-800 mg daily in 2 divided doses adjusted according to response, for 3-6 mth or if necessary, up to 9 mth. Benign breast disorders Adult: Initially, 100-400 mg daily in 2 divided doses adjusted according to response and continued for 3-6 mth. Gynaecomastia Adult: Male adolescents: Initially, 200 mg daily, may increase to 400 mg daily after 2 mth if no response occurs; adult men: Initial: 400 mg daily in up to 4 divided doses. Usual treatment duration: 6 mth. Child: Male adolescents: Initially, 200 mg daily increased to 400 mg after 2 mth if no response...
... Show moreContraindication
Hypersensitivity, pregnancy, lactation, porphyria, thromboembolic disorders; undiagnosed genital bleeding, markedly impaired renal, cardiac or hepatic dysfunction.
Mode of Action
Danazol suppresses the pituitary-ovarian axis by reducing the release of follicle-stimulating hormone and luteinizing hormone. This causes the regression and atrophy of endometrial tissue, decreases growth rate of abnormal breast tissue and reduces attacks in hereditary angioedema.
Precaution
Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Since hepatic dysfunction manifested by modest increases in serum transaminases levels has been reported in patients treated with Danazol, periodic liver function tests should be performed Administration of danazol has been reported to cause exacerbation of the manifestations of acute intermittent porphyria.
Lactation: enters breast milk/contraindicated
Side Effect
Frequency Not Defined
Intracranial hypertension,Increased blood pressure,Thromboembolism,Anxiety,Depression,Dizziness,Urticaria
Androgenic Effects (common)
Mild hirsutism,Decreased breast size,Voice changes,Sore throat, acne,Increased oiliness of skin or hair,Hair loss,Menstrual irregularities (common),Gastroenteritis,Nausea,Vomiting,Elevated LFTs,Joint pain,Muscle spasm
Potentially Fatal: Thromboembolic events and fatal strokes have been reported.
Pregnancy Category Note
Pregnancy Category: X
Lactation: enters breast milk/contraindicated
Interaction
Increased serum levels of ciclosporin, warfarin, carbamazepine and tacrolimus.
Potentially Fatal: Increased incidence of insulin resistance in diabetic patients.
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