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Dapazin 5
Concord Pharmaceuticals Ltd.
Generic: Dapagliflozin propanediol
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Dapazin 5.
CONSULT YOUR DOCTOR
Dapazin 5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Dapazin 5 during breastfeeding is not available. Please consult your doctor.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
UNSAFE
Dapazin 5 is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
CAUTION
Dapazin 5 should be used with caution in patients with liver disease. Dose adjustment of Dapazin 5 may be needed. Please consult your doctor.
Medicine Overview of Dapazin 5mg Tablet
Introduction
Dapazin 5 is used alone or in combination with other medicines to treat type 2 diabetes mellitus. It helps control the high blood sugar levels seen in diabetes. This reduces the chances of serious complications of diabetes and also helps prevent heart disease. Dapazin 5 can be taken with or without food at any time of day but you should try to take it at the same time every day. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at...
... Show moreUses of Dapazin 5
- Type 2 diabetes mellitus
Side effects of Dapazin 5
Common
- Nausea
- Frequent urge to urinate
- Genital fungal infection
- Increased thirst
- Urinary tract infection
How to use Dapazin 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dapazin 5 may be taken with or without food, but it is better to take it at a fixed time.
How Dapazin 5 works
Dapazin 5 is an antidiabetic medication. It works by removing excess sugar from your body through urine.
What if you forget to take Dapazin 5?
If you miss a dose of Dapazin 5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Dapazin 5 is used alone or together with other diabetes medicines to control blood sugar and avoid long-term complications.
- It may cause your body to lose too much fluid (dehydration) or you may urinate more often. Drink plenty of water and stay hydrated.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene.
- Monitor your blood sugar regularly while taking this medicine.
- Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms or unexplained nausea/vomiting.
Brief Description
Indication
Type 2 diabetes mellitus
Adult Dose
Diabetes Mellitus Type 2
Selective sodium-glucose transporter-2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control with type 2 diabetes mellitus
Initial: 5 mg PO qDay; take in am with or without food
May increase to 10 mg qDay in patients tolerating 5 mg/day who have an eGFR ?60 mL/min/1.73 m² and require additional glycemic control
Indicated as monotherapy, as initial therapy with metformin, or as an add-on to other oral glucose-lowering agents, including metformin, glimepiride, sitagliptin, and insulin
Hepatic impairment
Mild or moderate: No dosage adjustment required
Severe: Not studied
Renal Dose
Renal impairment
eGFR ?60 mL/min/1.73 m²: No dosage adjustment required
eGFR <60 mL/min/1.73 m²: Do not initiate
Not recommended with eGFR that declines persistently between 30 to <60 mL/min/1.73 m²
eGFR <30 mL/min/1.73 m²: Contraindicated
Contraindication
Hypersensitivity to dapagliflozin propanediol or to any of the excipients. Moderate to severe renal impairment; end-stage renal disease; active bladder cancer. Pregnancy (2nd & 3rd trimester) & lactation.
Mode of Action
Dapagliflozin is a highly potent, selective, and reversible inhibitor of sodium-glucose cotransporter 2 (SGLT2) that improves glycemic control in patients with type 2 diabetes mellitus by reducing renal glucose reabsorption leading to urinary excretion of excess glucose (glucuresis).
Precaution
CV disease; history of hypotension. Monitor vol status & electrolytes. UTI. Childn. Elderly.
Lactation: Unknown whether distributed in human breast milk; breast feeding women should discontinue dapagliflozin or nursing taking into account the importance of the drug to the mother
Side Effect
>10%
Renal impairment
1-10%
Female genital mycotic infections (6.9-8.4%),Urinary tract infection (4.3-5.7%),Increased urination (2.9-3.8%),Male genital mycotic infections (2.7-2.8%),Dyslipidemia (2.1-2.5%),Constipation (1.9-2.2%),Discomfort with urination (2.6-2.1%),Extremity pain (1.7-2%),Volume depletion
<1%
Hypersensitivity (0.3%)
Pregnancy Category Note
Pregnancy Based on animal data showing adverse renal effects drug is not recommended during second and third trimesters of pregnancy Limited data in pregnant women are not sufficient to determine drug-associated risk for major birth defects or miscarriage; there are risks to mother and fetus associated with poorly controlled diabetes in pregnancy In animal studies, adverse renal pelvic and tubule dilatations, that were not fully reversible, were observed in rats when administered during a period of renal development corresponding to late second and third trimesters of human pregnancy, at all doses tested Clinical considerations Poorly controlled diabetes in pregnancy increases...
... Show moreInteraction
Hypoglycemia may occur w/ concomitant use w/ insulin & insulin secretagogues eg sulfonylureas. Decrease in Cmax & AUC w/ rifampin. Increase in Cmax & AUC w/ mefenamic acid. Increased thiazide & loop diuretic effects; may increase risk of dehydration & hypotension. Pioglitazone.
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