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Darifen ER
The ACME Laboratories Ltd.
Generic: Darifenacin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Darifen ER. Please consult your doctor.
CONSULT YOUR DOCTOR
Darifen ER may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Darifen ER is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Darifen ER may cause side effects which could affect your ability to drive.
Darifen ER may cause effects such as dizziness, blurred vision, trouble sleeping or drowsiness. This may affect your driving ability.
SAFE IF PRESCRIBED
Darifen ER is safe to use in patients with kidney disease. No dose adjustment of Darifen ER is recommended.
However, inform your doctor if you have any underlying kidney disease.
CAUTION
Darifen ER should be used with caution in patients with liver disease. Dose adjustment of Darifen ER may be needed. Please consult your doctor.
Use of Darifen ER is not recommended in patients with severe liver disease.
Medicine Overview of Darifen ER 15mg Tablet
Introduction
Darifen ER is muscarinic antagonist that is used in the treatment of overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination. Darifen ER is advised to take it in a dose and duration as per prescription. It can be taken with or without food. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine. Some...
... Show moreUses of Darifen ER
- Overactive bladder (OAB) symptoms
Side effects of Darifen ER
Common
- Blurred vision
- Constipation
- Dryness in mouth
- Indigestion
- Headache
- Nausea
How to use Darifen ER
Use it as advised by your doctor or check the label for directions before use. Darifen ER may be taken with or without food, but it is better to take it at a fixed time.
How Darifen ER works
Darifen ER is an antimuscarinic. It works by relaxing muscles of the urinary bladder to prevent frequent, urgent or uncontrolled urination.
What if you forget to take Darifen ER?
If you miss a dose of Darifen ER, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Dariten OD 7.5mg Tablet PR helps you to have better control over your urination by relaxing your bladder which increases its capacity to hold urine, thereby reducing the need to pass urine.
- It may cause blurred vision, fatigue and sleepiness. Be cautious while driving or doing anything that requires focus.
- It may cause dry mouth. Try chewing on sugar-free gum or taking small sips of water.
- Avoid caffeine, alcohol or carbonated drinks as they can worsen your symptoms.
- Do not stop taking this medicine if you do not notice an improvement in your symptoms as it may take some time for your bladder to adapt and your symptoms to improve.
Brief Description
Indication
Urge incontinence, Urinary frequency and urgency, Overactive bladder
Administration
May be taken with or without food. Swallow whole, do not chew/crush/divide.
Adult Dose
Oral
Overactive bladder
Adult: For symptomatic treatment of urge incontinence, urinary frequency and urgency. Initial: 7.5 mg once daily; may increase dose to 15 mg once daily if no adequate response after 2 wk of therapy.
Hepatic impairment: Moderate hepatic impairment (Child Pugh B): Maximum daily dose is 7.5 mg. Severe hepatic impairment (Child Pugh C): Not recommended.
Contraindication
Patient with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and in patients who are at risk for these conditions.
Mode of Action
Darifenacin is a potent, competitive and selective muscarinic receptor antagonist which has greater binding affinity for muscarinic M3 receptors. M3 receptors are involved in the contraction of the detrusor muscle of the bladder, GI smooth muscle, saliva production, and iris sphincter function. Darifenacin may increase volume threshold in patients with involuntary detrusor contraction, thus increase bladder capacity.
Precaution
Anticholinergic agents including Darifenacin, may cause urinary retention and decreased GI motility. Caution when used in patients with clinically significant bladder outflow obstruction, GI obstructive disorder (e.g. pyloric stenosis), severe constipation, ulcerative colitis, and myasthenia gravis. For patients being treated for narrow-angle glaucoma, caution and only use where potential benefits outweigh the risks. May cause heat prostration when used in a hot environment. May cause dizziness and blurred vision; caution when operating machinery or driving vehicle. Not recommended in severe hepatic impairment. Safety and efficacy have not been established in paediatric patients. Pregnancy and lactation. Lactation: Excretion in milk unknown;...
... Show moreSide Effect
>10%
Dry mouth (19-35%),Constipation (15-21%)
1-10%
Abdominal pain (2-4%),Dizziness (2%),Dry eyes (2%),Dyspepsia (3-8%),Nausea (2-4%),UTI (4-5%),Vaginitis (>1%),Back pain (>1%),Rhinitis (>1%),Abnormal vision (>2%),Vomiting (>1%),Weight gain (>1%),Flu-like syndrome (1-3%),Peripheral edema (>1%)
Potentially Fatal: Hypersensitivity reactions, including angioedema.
Pregnancy Category Note
Pregnancy Category: C
Lactation: Excretion in milk unknown; use caution
Interaction
Concurrent use of CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, nefazodone, troleandomycin, ritonavir, nelfinavir) or CYP2D6 inhibitors (e.g. quinidine, paroxetine) may increase serum levels of Darifenacin. CYP3A4 inducers (e.g. barbiturates, phenytoin, rifampicin) may likely decrease Darifenacin serum concentrations. Darifenacin may act as a moderate inhibitor of CYP2D6, caution when used concomitantly with CYP2D6 substrates that have narrow therapeutic index (e.g. flecainide, thioridazine, imipramine). Concurrent use of another agent with antimuscarinic properties may potentiate the side effects of Darifenacin.
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