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Degram
Doctor's Chemicals Works Ltd.
Generic: Nalidixic Acid
Safety Advices
বাংলা
English
UNSAFE
Degram may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Degram may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Degram is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Degram does not usually affect your ability to drive.
CAUTION
Degram should be used with caution in patients with kidney disease. Dose adjustment of Degram may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advised if this medicine is to be taken for a long time.
CAUTION
Degram should be used with caution in patients with liver disease. Dose adjustment of Degram may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised if this medicine is to be taken for a long time.
Medicine Overview of Degram 500mg Tablet
Introduction
Degram is an antibiotic, used in the treatment of bacterial infections. It is also used in treating infections of the urinary tract, nose, throat, skin and soft tissues and lungs (pneumonia). It cures the infection by stopping the further growth of the causative microorganisms. Degram should be used in the dose and duration as advised by your doctor. It may be taken with or without food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose....
... Show moreUses of Degram
- Bacterial infections
Side effects of Degram
Common
- Nausea
- Diarrhea
How to use Degram
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Degram is to be taken empty stomach.
How Degram works
Degram is an antibiotic. It works by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them.
What if you forget to take Degram?
If you miss a dose of Degram, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Degram to cure your infection and improve symptoms.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Discontinue Degram and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
- Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Brief Description
Indication
Lower urinary tract infections, Shigellosis
Administration
Should be taken with food.
Adult Dose
Oral
Uncomplicated lower urinary tract infections
Adult: 1 g 4 times daily for 1-2 wk. Long-term therapy: Reduce daily dose to 2 g.
Shigellosis
Adult: 1 g 4 times daily for 5 days.
Hepatic impairment: Reduced doses should be considered.
Child Dose
Oral
Uncomplicated lower urinary tract infections
Child: >3 mth: 50 mg/kg daily in 4 equally divided doses. Long-term therapy: Reduce dose to 30 mg/kg daily. Prophylaxis: 15 mg/kg bid.
Shigellosis
Child: >3 mth: 15 mg/kg 4 times daily for 5 days.
Renal Dose
Renal impairment: Reduced doses should be considered.
Contraindication
Hypersensitivity. History of convulsive disorders or porphyria. Infants <3 mth. Severe renal impairment.
Mode of Action
Nalidixic acid is a 4-quinolone antibacterial. It interferes with the replication of bacterial DNA by inhibiting DNA gyrase activity. It acts against gram-negative bacteria including E. coli, Proteus, Klebsiella, Enterobacter, Salmonella and Shigella spp.
Precaution
Hepatic or moderate renal impairment, severe cerebral arteriosclerosis, G6PD deficiency. Monitor blood counts, renal and hepatic function for treatment >2 wk. Children <18 yr. Elderly. Avoid exposure to sunlight or sunlamps. Pregnancy and lactation.
Side Effect
Nausea, vomiting, diarrhoea, abdominal pain; photosensitivity reactions, allergic rash, urticaria, pruritus; visual disturbances, headache, dizziness or vertigo, drowsiness, confusion, depression, excitement, hallucinations, toxic psychoses or convulsions (especially after large doses), intracranial hypertension (especially in infants and young children), metabolic acidosis; peripheral neuropathies, muscular weakness, myalgia; arthralgia, tendon damage; cholestatic jaundice, thrombocytopenia, leucopenia.
Potentially Fatal: Erythema multiforme and Stevens-Johnson syndrome; anaphylactoid reactions. Auto-immune haemolytic anaemia (particularly in elderly patients).
Interaction
Absorption reduced by sucralfate, and divalent and trivalent cations e.g. aluminium, calcium, iron, magnesium, zinc. Excretion reduced and plasma concentrations increased with probenecid. Reduced effects with chloramphenicol, nitrofurantoin, tetracycline.
Potentially Fatal: Fatal haemorrhagic enterocolitis may occur when used with high-dose melphalan in children. Increased risk of nephrotoxicity with ciclosporin. May increase effects of oral anticoagulants e.g. warfarin.
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