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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Deloxi.
CONSULT YOUR DOCTOR
Deloxi may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Deloxi is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Deloxi may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Deloxi should be used with caution in patients with severe kidney disease. Dose adjustment of Deloxi may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild and moderate kidney disease.
UNSAFE
Deloxi is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Deloxi 20mg Capsule
Introduction
Deloxi is a prescription medicine used in the treatment of depression, anxiety disorder, diabetic nerve pain, fibromyalgia (a condition in which there are generalized pain and tenderness in the body), neuropathic pain and stress urinary incontinence. Deloxi works by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relax the nerves, thus treating your illness. It may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any...
... Show moreUses of Deloxi
- Depression
- Anxiety disorder
- Diabetic nerve pain
- Fibromyalgia
- Neuropathic pain
- Stress urinary incontinence
Side effects of Deloxi
Common
- Nausea
- Headache
- Dryness in mouth
- Sleepiness
- Dizziness
How to use Deloxi
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Deloxi may be taken with or without food, but it is better to take it at a fixed time.
How Deloxi works
Deloxi works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
What if you forget to take Deloxi?
If you miss a dose of Deloxi, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Duzela 20 Capsule DR helps in treating depression and anxiety.
- It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
- It may take 2 to 4 weeks for Duzela 20 Capsule DR to start working. Keep taking it as prescribed.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Duzela 20 Capsule DR as it may cause excessive drowsiness and increase the risk of liver damage.
- It may cause an increase in blood pressure, especially during the first month of treatment. Monitor your blood pressure regularly.
- It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Major Depressive Disorder (MDD), Fibromyalgia, Diabetic neuropathy, Stress urinary incontinence, Generalized anxiety disorder, Interstitial cystitis, Musculoskeletal pain
Administration
May be taken with or without food. Swallow whole, do not chew/crush.
Adult Dose
Oral Major Depressive Disorder Adult: Initially, 20-30 mg bid or 60 mg once daily, then increase dose in increments of 30 mg/day over 1 wk as tolerated. Max: 120 mg/day. Diabetic Peripheral Neuropathic Pain Adult: 60 mg once daily. Max: 120 mg/day in divided doses. Generalized Anxiety Disorder Adult: 30 or 60 mg once daily. Max: 120 mg/day. Fibromyalgia Adult: Initially, 30 mg once daily for 1 wk, then increase to 60 mg once daily. Elderly Major Depressive Disorder May initiate at 20 mg PO qDay or divided BID; increase to 40-60 mg qDay or divided doses; alternatively, initiate at...
... Show moreChild Dose
Generalized Anxiety Disorder
60 mg/day; if increased beyond 60 mg/day, use increments of 30 mg/day
Maximum dose studied was 120 mg/day; safety of doses >120 mg/day has not been evaluated
Renal Dose
Renal Impairment
Avoid use in patients with severe renal impairment (GFR <30 mL/min)
Contraindication
Duloxetine is contraindicated in patients with a known hypersensitivity to this drug or any of the inactive ingredients.. Uncontrolled narrow-angle glaucoma. Concomitant use or within 2 wk of MAOIs. Renal and hepatic impairment.
Mode of Action
Duloxetine is a potent inhibitor of neuronal reuptake of serotonin, norepinephrine and to a lesser extent dopamine. It has no significant affinity for adrenergic, muscarinic, cholinergic, histaminergic, opioid, glutamate and GABA receptors. It also does not inhibit monoamine oxidase.
Precaution
Avoid alcohol and abrupt cessation. May impair ability to drive or engage in task requiring alertness. Increased risk of suicidal thinking and behaviour when used in children and adolescents. Pregnancy, lactation.
Lactation: Drug enters breast milk; use not recommended unless benefits greatly outweigh risks
Side Effect
>10%
Nausea (23-25%),Dry mouth (13-15%),Headache (13-14%),Somnolence (10-12%),Fatigue (10-11%)
1-10%
Constipation (10%),Dizziness (10%),Insomnia (10%),Diarrhea (9-10%),Anorexia (8%),Decreased appetite (7-8%),Abdominal pain (6%),Hyperhidrosis (6%),Increased sweating (6%),Agitation (5%),Nasopharyngitis (5%),Vomiting (3-5%),Male sexual dysfunction (2-5%),Abdominal pain (4%),Decreased libido (4%),Musculoskeletal pain (4%),Upper respiratory tract infection (URTI) (4%),Abnormal orgasm (3%),Agitation (3%),Anxiety (3%),Blurred vision (3%),Cough (3%),Influenza (3%),Muscle spasms (3%),Tremor (3%),Abnormal dreams (2%),Dyspepsia (2%),Hot flushes (2%),Nausea (2%),Oropharyngeal pain (2%),Palpitations (2%),Paresthesia (2%),Weight loss (2%),Yawning (2%),Dysuria (>1%),Gastritis (>1%),Rash (>1%)
Pregnancy Category Note
Pregnancy There are no adequate and well-controlled studies administration in pregnant women Use in pregnancy only if the potential benefit justifies the potential risk to the fetus Clinical considerations Neonates exposed during pregnancy to serotonin - norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs) have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding which can arise immediately upon delivery Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying These features are consistent with either a direct toxic effect of the...
... Show moreInteraction
Increased risk of serotonin syndrome w/ TCA, SSRI, SNRI, lithium. May increase bleeding risk w/ aspirin, NSAIDs, warfarin and other anticoagulants.
Potentially Fatal: Increased risk of serotonin syndrome w/ MAOIs, linezolid and methylene blue. Increased serum levels and risk of toxicity w/ potent CYP1A2 inhibitors (e.g. ciprofloxacin, enoxacin).
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