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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Demarin.
CONSULT YOUR DOCTOR
Demarin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Demarin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Demarin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Demarin should be used with caution in patients with kidney disease. Dose adjustment of Demarin may be needed. Please consult your doctor.
CAUTION
Demarin should be used with caution in patients with liver disease. Dose adjustment of Demarin may be needed. Please consult your doctor.
Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.
Medicine Overview of Demarin 600mg Tablet
Introduction
Demarin is a pain relieving medicine. It provides relief to pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, and juvenile arthritis. It also helps in relieving muscle and joint pain, headache, fever, toothache, and menstrual cramps. Demarin should be taken with food to avoid stomach upset and reduce side effects. In general, you should try to use the smallest amount necessary to control your symptoms, for the shortest possible time. You should take this medicine regularly while you need it. Try not to miss doses as it will become less effective if you do. The common...
... Show moreUses of Demarin
- Fever
- Headache
- Arthralgia (joint pain)
- Muscle pain
- Dental pain
- Post operative pain
- Pain during menstruation
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Gout
Side effects of Demarin
Common
- Vomiting
- Nausea
- Indigestion
How to use Demarin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Demarin may be taken with or without food, but it is better to take it at a fixed time.
Avoid Demarin with herbs/food with anti-platelet activity such as alfalfa, anise, bilberry, grape seed, green tea, turmeric, fenugreek, garlic, ginger.
How Demarin works
Demarin is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).
Quick Tips
- You have been prescribed Demarin to relieve pain and inflammation.
- Take it with food or milk to prevent upset stomach.
- Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
- Do not take indigestion remedies (antacids) within two hours of taking Demarin.
- Avoid consuming alcohol while taking Demarin as it can increase your risk of stomach problems.
- Inform your doctor if you have a history of heart disease or stroke.
- Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Brief Description
Indication
Rheumatoid arthritis, Osteoarthritis, Juvenile rheumatoid arthritis
Administration
Take with food or water to avoid GI effects
Adult Dose
Osteoarthritis
Initial in mild to moderate disease: 600mg PO qDay
Usual in moderate to severe disease: 1200mg PO qDay
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Rheumatoid Arthritis
1200mg PO qDay (individualize)
Maximum 1,800 mg/day or 26 mg/kg/day, whichever is lower, divided PO q12hr
Hepatic Impairment
Caution in patients with severe liver impairment
Child Dose
Juvenile Rheumatoid Arthritis
6 years
22-31 kg: 600 mg PO qDay
32-54 kg: 900 mg PO qDay
>55 kg: 1200 mg PO qDay
Renal Dose
Renal Impairment
Severe renal impairment or on dialysis: 600 mg PO qDay; may increase to 1200 mg/day; monitor closely
Contraindication
Previous or active peptic ulceration, known hypersensitivity to NSAIDs. Perioperative pain in CABG setting.
Mode of Action
Oxaprozin is a propionic acid derivative NSAID. It inhibits the enzyme cyclooxygenase resulting in the blockage of prostaglandin synthesis.
Precaution
Be alert for ulceration and bleeding in patients treated chronically. History of serious GI events, alcoholism, smoking, other factors known to be associated with peptic ulcer. Elderly or debilitated patients. Uncompensated cardiac failure, history of hypertension, cardiac decompensation, chronic diuretic therapy, conditions predisposing to fluid retention. Renal and hepatic impairment. Underlying coagulation defects or patients who are undergoing surgical procedures where a high degree of haemostasis is required. Pregnancy (avoid in 3rd trimester) and lactation.
Lactation: not known whether excreted in breast milk; effect on infant unknown
Side Effect
Common
Edema,Rash,Abdominal pain,Anorexia,Constipation,Diarrhea,Indigestion,Nausea/Vomiting,GI ulcer,Gross bleeding with perforation,Heartburn,Anemia,LFT's increased.Tinnitus,Dysuria, Increased frequency of urination,Myocardial infarction (<2%)
<1%
Hypertension (<1%),Palpitations (<1%),Thrombotic tendency observations,Erythema multiforme (rare),Scaling eczema,Stevens-Johnson syndrome (rare),Toxic epidermal necrolysis (rare),Cerebrovascular accident,Gastrointestinal hemorrhage (<1%),Agranulocytosis (rare),Leukopenia (<1%),Thrombocytopenia (<1%),Hepatitis (rare),Jaundice, Liver failure,Anaphylactoid reaction (<1%),Amblyopia (<1%),Hearing loss (<1%),Acute renal failure (rare),Hematuria (rare),Interstitial nephritis (rare),Bronchospasm,Serum sickness due to drug (rare)
Potentially Fatal: Anaphylactoid reactions, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe hepatic reactions.
Pregnancy Category Note
Pregnancy Category: C; D in 3rd trimester or near delivery.
Interaction
Increased risk of salicylate toxicity with aspirin. May increase effects of oral anticoagulants. May reduce effects of beta-blockers, diuretics and other antihypertensive agents. May increase risk of methotrexate and lithium toxicity.
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