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Denitine
Doctor's Chemicals Works Ltd.
Generic: Ranitidine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Denitine.
SAFE IF PRESCRIBED
Denitine is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Denitine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Denitine does not usually affect your ability to drive.
CAUTION
Denitine should be used with caution in patients with kidney disease. Dose adjustment of Denitine may be needed. Please consult your doctor.
CAUTION
Denitine should be used with caution in patients with liver disease. Dose adjustment of Denitine may be needed. Please consult your doctor.
Medicine Overview of Denitine 150mg Tablet
Introduction
Denitine is a medicine that reduces the amount of excess acid make by your stomach. It is used to treat and prevent heartburn, indigestion and other symptoms caused by too much acid in the stomach. It is also used to treat and prevent stomach ulcers, reflux disease and some other rare conditions. Denitine is also commonly prescribed to prevent stomach ulcers and heartburn caused by the use of painkillers. It can be taken with or without food. How much you need, and how often you take it will depend on what you are being treated for. Follow the advice of...
... Show moreUses of Denitine
- Gastroesophageal reflux disease (Acid reflux)
- Peptic ulcer disease
Side effects of Denitine
Common
- Sleepiness
- Headache
- Tiredness
- Constipation
- Diarrhea
How to use Denitine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Denitine may be taken with or without food, but it is better to take it at a fixed time.
How Denitine works
Denitine is a histamine H2 receptor antagonist. It works by reducing the acid produced in the stomach. This helps to relieve acid-related indigestion and heartburn.
What if you forget to take Denitine?
If you miss a dose of Denitine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- If you are also taking other medications to treat acidity (e.g., antacid), take them 2 hours before or after taking Denitine.
- Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
- Inform your doctor if you do not feel better after taking Denitine for 2 weeks as you may be suffering from some other problems.
- Inform your doctor if you have ever been diagnosed with kidney disease as dose of your medicine may need to be adjusted.
- Do not stop taking the medication without talking to your doctor.
Brief Description
Indication
Dyspepsia, H. pylori infection, Benign gastric and duodenal ulceration, GERD, Acid aspiration during general anesth, Prophylaxis during NSAID treatment, Stress ulceration of upper GI, Zollinger-Ellison syndrome
Administration
May be taken with or without food.
IV Administration
Direct injection: 50 mg diluted to ?20 mL with compatible IV infusion fluid and given over ?5 minutes (4 mL/min)
Intermittent infusion: 50 mg added to ?100 mL of compatible IV solution and infused over 15-20 minutes
Continuous infusion: 150 mg diluted in 250 mL of IV fluid and infused at 6.25 mg/hr for 24 hours
Adult Dose
Oral Benign gastric and duodenal ulceration Adult: Initially, 300 mg daily at bedtime or 150 mg bid for 4-8 wk; 300 mg bid for 4 wk may be used in duodenal ulcer to improved healing. Maintenance: 150 mg daily at bedtime. Max: 300 mg bid. Hypersecretory conditions Adult: Initially, 150 mg bid or tid and increased if needed. Max: 6 g daily. Gastro-oesophageal reflux disease Adult: 150 mg bid or 300 mg at bedtime for up to 8 wk, may increase to 150 mg 4 times daily for 12 wk in severe cases. Dyspepsia Adult: Chronic episodic: 150 mg bid...
... Show moreChild Dose
Oral
Benign gastric and duodenal ulceration
Child: 1 mth to 16 yr 4-8 mg/kg daily in 2 divided doses. Max: 300 mg/day. Treatment duration: 4-8 wk. Maintenance: 2-4 mg/kg once daily. Max: 150 mg/day.
Gastro-oesophageal reflux disease
Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 300 mg/day.
Erosive oesophagitis
Child: 1 mth to 16 yr 5-10 mg/kg daily in 2 divided doses. Max: 600 mg/day.
Renal Dose
Oral:
CrCl Dosage
<50 150 mg daily at bedtime, adjust dose cautiously if necessary.Parenteral:
Individual doses may be reduced to 25 mg.
Contraindication
Porphyria.
Mode of Action
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Precaution
Possibility of malignancy should be excluded prior to therapy as the drug may mask symptoms and delay diagnosis of gastric malignancy. Patients w/ difficulty in swallowing. Renal and hepatic impairment. Pregnancy and lactation.
Lactation: Drug crosses into breast milk; discontinue drug, use caution
Side Effect
1-10%
Headache (3%)
<1%
Abdominal pain,Agitation,Alopecia,Confusion,Constipation,Diarrhea,Dizziness,Hypersensitivity reaction,Nausea,Vomiting
Frequency Not Defined
Anemia,Necrotizing enterocolitis in fetus or newborn,Pancreatitis (rare),Thrombocytopenia (rare),Pancytopenia (rare),Agranulocytosis (rare),Acquired immune hemolytic anemia (rare),Arthralgia (rare),Myalgia (rare)
Potentially Fatal: Anaphylaxis, hypersensitivity reactions.
Interaction
Delayed absorption and increased peak serum concentration w/ propantheline bromide. Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability w/ antacids.
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