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Safety Advices
বাংলা
English
SAFE IF PRESCRIBED
Derfin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
CONSULT YOUR DOCTOR
Derfin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medicine Overview of Derfin 250mg Tablet
Introduction
Derfin is used to treat a wide range of fungal infections of the skin and nails, including ringworm. It works by killing the fungus that causes the infection. Derfin is for external use only. It should be used in the dose and duration suggested by the doctor. Applying it at the same time every day will help you remember to use it. The affected area should be clean and dry before application of the ointment. You must wash your hands thoroughly before and after applying this medicine. Do not stop using it until you have finished the complete course, even...
... Show moreUses of Derfin
- Fungal skin infections
Side effects of Derfin
Common
- Skin peeling
How to use Derfin
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
How Derfin works
Derfin is an antifungal medication which treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane.
What if you forget to take Derfin?
If you miss a dose of Derfin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Derfin helps treat skin infections caused by many different types of fungi.
- Finish the full course of treatment even if you feel better.
- It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color.
- Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
- It can make your skin more sensitive to sun. Use broad-spectrum sunscreen and protective clothing when outdoors.
- Avoid getting in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
- Inform your doctor if the infection has not cleared up after four weeks of treatment.
Brief Description
Indication
Tinea pedis, Tinea cruris, Tinea corporis, Dermatophytosis, Nail infections
Administration
May be taken with or without food.
Adult Dose
Oral
Onychomycosis
Adult: 250 mg once daily for 6 weeks (fingernail) or 12 weeks (toenail)
Tinea Pedis, Tinea Corporis, Tinea Cruris
Adult: 250 mg/day PO in single dose or divided q12hr
2-4 wk in tinea cruris, tinea corporis
2-6 wk for tinea pedis
Hepatic impairment: Use not recommended in chronic or active liver disease
Child Dose
Tinea Capitis
>4 years (4 years (25-35 kg): 187.5 mg/day PO for 6 weeks
>4 years (>35 kg): 250 mg/day PO for 6 weeks
Renal Dose
Renal impairment: Use not recommended if CrCl <50 mL/min
Contraindication
Hypersensitivity, active or chronic liver disease, lactation.
Mode of Action
Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.
Precaution
Preexisting liver or renal impairment, pregnancy. Perform liver function tests prior to oral therapy.
Lactation: Drug excreted in breast milk; do not use
Side Effect
>10%
Headache (13%)
1-10%
Rash (6%),Pruritus (3%),Nausea (3%),Diarrhea (6%),Dyspepsia (4%),Abdominal pain (2%),Taste disturbance (3%),Elevated liver function test results (3%),Visual disturbance (1%)
Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.
Interaction
Possible increase in levels in drugs metabolised by CYP450 2D6. Decreased terbinafine concentration with rifampicin; increased terbinafine concentration with cimetidine.
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