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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Desirox Dis. Please consult your doctor.
CONSULT YOUR DOCTOR
Desirox Dis may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Desirox Dis is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Desirox Dis may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
UNSAFE
Desirox Dis is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
CAUTION
Desirox Dis should be used with caution in patients with liver disease. Dose adjustment of Desirox Dis may be needed. Please consult your doctor.
Limited information is available on the use of Desirox Dis in these patients.
Medicine Overview of Desirox Dis 500mg Tablet
Introduction
Desirox Dis is a medicine used in the treatment of chronic iron overload caused by frequent blood transfusion. It helps remove the excess iron from the body and reduce the risk of it causing organ damage.
Desirox Dis should be taken in empty stomach. Take it regularly at a fixed time each day to get the maximum benefit of the medicine.
Using of Desirox Dis may cause common side effects such as nausea, headache, constipation, diarrhea and increased liver enzyme. If the side effects persist or worsen, inform your doctor.
Uses of Desirox Dis
- Iron overload
- Transfusion dependent thalassemia
Side effects of Desirox Dis
Common
- Nausea
- Headache
- Vomiting
- Rash
- Abdominal pain
- Constipation
- Itching
- Increased liver enzymes
- Abdominal distension
- Diarrhea
How to use Desirox Dis
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Desirox Dis is to be taken empty stomach.
How Desirox Dis works
Desirox Dis traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.
What if you forget to take Desirox Dis?
If you miss a dose of Desirox Dis, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Always take deferasirox tablet on an empty stomach by dissolving into a glass of water.
- Do not chew, crush, break or swallow the tablets as a whole.
- Deferasirox may cause dizziness. It is advisable not to drive or operate any machinery until you feel normal again.
- Avoid taking deferasirox if you are pregnant, planning to become pregnant or are breast feeding.
Brief Description
Indication
Chronic iron overload.
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 30 min before meals preferably at the same time daily. Disperse tab completely by stirring in 100-200 mL of water/apple juice/orange juice until a fine susp is obtained; consume entire content. Rinse the glass w/ a little water/juice to resuspend any residue & drink remainder. Do not disperse tab in fizzy drinks/milk.
Do not chew/ break/crush tab or swallow whole. Do not take w/ Al-containing antacids.
Adult Dose
Transfusional Hemosiderosis Indicated for treatment of chronic iron overload caused by blood transfusion 20 mg/kg PO qDay; may increase by 5-10 mg increments based on serum ferritin; if not controlled on 30 mg/kg/day (ie, serum ferritin persistently >2500 mcg/L), may increase up to 40 mg/kg qDay Nontransfusion-Dependent Thalassemia Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L 10 mg/kg PO qDay (calculate dose to nearest tablet size); if LIC >15 mg...
... Show moreChild Dose
Transfusional Hemosiderosis
Indicated for treatment of chronic iron overload caused by blood transfusion
2500 mcg/L), may increase up to 40 mg/kg qDay
Nontransfusion-Dependent Thalassemia
Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L
15 mg Fe/g dw after 4 weeks, consider increasing dose to 20 mg/kg/day
Renal Dose
Renal Impairment
Baseline renal impairment
CrCl 40-60 mL/min: Reduce starting dose by 50%
Serum Cr >2 xULN or CrCl <40 mL/min: Do not use
Contraindication
Hypersensitivity.
Mode of Action
Deferasirox is an orally active chelator that is selective for iron (as Fe3+ ion). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. It is used in the management of chronic iron overload.
Precaution
Monitor renal function and CBC before starting treatment and regularly during treatment; may need to reduce dose or stop treatment if serum creatinine levels are persistently elevated. May increase LFTs. Perform audiological and ophthamological tests before starting treatment and yrly thereafter. Pregnancy.
Lactation: not known whether excreted in breast milk, use caution
Side Effect
>10%
Serum creatinine increase (dose related; 7-38%),Abdominal pain (21-28%),Nausea (11-23%),Vomiting (10-21%),Diarrhea (12-20%),Proteinuria (19%),Pyrexia (19%),Headache (16%),Cough (14%),Nasopharyngitis (13%),Pharyngolaryngeal pain (11%),Influenza (11%),Rash (8-11%)
1-10%
Respiratory tract infection (10%),Bronchitis (9%),ALT increased (2-8%),Arthralgia, back pain (6-7%),Acute tonsillitis (6%),Rhinitis (6%),Fatigue (6%),Ear infection (5%),Transaminitis (4%),Urticaria (4%)
<1%
Anaphylaxis,Angioedema,Cytopenias, including agranulocytosis, neutropenia and thrombocytopenia; leukocytoclastic vasculitis
Potentially Fatal: Acute renal failure, serious hypersensitivity reactions such as angioedema and anaphylaxis.
Pregnancy Category Note
Pregnancy There are no studies with use in pregnant women to inform drug-associated risks; administration of deferasirox to rats during pregnancy resulted in decreased offspring viability and an increase in renal anomalies in male offspring at doses that were about or less than recommended human dose on a mg/ m² basis; no fetal effects were noted in pregnant rabbits at doses equivalent to human recommended dose on a mg/ m² basis; drug should be used during pregnancy only if potential benefit justifies potential risk to fetus Contraception Counsel patients to use non-hormonal method(s) of contraception since drug can render hormonal...
... Show moreInteraction
Not to be used with aluminium-containing antacids as it may chelate aluminium.
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