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CA-ATRA 10
Jenome Biophar Pvt Ltd
Generic: Tretinoin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
CA-ATRA 10 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
CA-ATRA 10 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Medicine Overview of CA-ATRA 10mg Softgel Capsule
Introduction
CA-ATRA 10 is a form of vitamin A that is used to treat acne which appears as spots or pimples on your face, chest or back. It also helps to smooth rough facial skin and to reduce fine wrinkles on the skin. CA-ATRA 10 reduces excessive oil production of the skin. Ideally, a pinpoint application at nighttime is recommended for the duration prescribed by your doctor. The amount you need and for how long you need to take it will depend on what you are being treated for. You should normally wash and dry the affected area before applying a...
... Show moreUses of CA-ATRA 10
- Acne
Side effects of CA-ATRA 10
Common
- Erythema (skin redness)
- Skin irritation
- Dry skin
- Dry lips
- Pale red skin
- Increased sensitivity to light
How to use CA-ATRA 10
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
How CA-ATRA 10 works
CA-ATRA 10 is a form of vitamin A. When applied on skin, it reduces oil production in the skin, replenishes acne-prone skin and helps keep your pores open.
What if you forget to take CA-ATRA 10?
If you miss a dose of CA-ATRA 10, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed CA-ATRA 10 for the treatment of acne.
- Clean the affected area with water and a non-medicated soap. Let it dry for 20-30 minutes before applying CA-ATRA 10.
- It may increase the severity of the spots or pimples in the first few weeks of use. Continue using it as prescribed by your doctor.
- It may cause a stinging sensation or a feeling of warmth when you first start using it. Inform your doctor if this persists.
- Avoid exposure to sunlight while using CA-ATRA 10 as it increases the sensitivity of your skin. Use protective measures such as sunscreen or protective clothing.
- Avoid face waxing and laser treatment while using this medicine as it makes your skin more fragile.
- Avoid taking tetracycline (e.g. doxycycline) as it may reduce the CA-ATRA 10 activity.
- Do not use CA-ATRA 10 if you are pregnant.
- Inform your doctor if excessive skin dryness or skin sensitivity take place.
Brief Description
Indication
Acute promyelocytic leukaemia
Administration
Should be taken with food.
Adult Dose
Oral
Acute promyelocytic leukaemia
Adult: Remission induction: 45 mg/m2 daily in 2 divided doses. Treatment is continued until 30 days after complete remission or up to 90 days, whichever occurs first.
Hepatic impairment: Reduce dose to 25 mg/m2 daily.
Child Dose
Oral
Acute promyelocytic leukaemia
Child: Remission induction: 1-16 yr 45 mg/m2 daily in 2 divided doses. Treatment is continued until 30 days after complete remission or up to 90 days, whichever occurs first.
Hepatic impairment: Reduce dose to 25 mg/m2 daily.
Renal Dose
Renal impairment: Reduce dose to 25 mg/m2 daily.
Contraindication
Hypersensitivity to retinoids. Application to eczematous, sunburnt or abraded skin. Pregnancy, lactation.
Mode of Action
Tretinoin is a trans-retinoic acid form of vitimin A. It stimulates mitosis and turnover of follicular epithelial cells and reduce their cohesiveness. This facilitates extrusion of existing comedones and prevents formation of new comedone. It also exhibits thinning effect on the stratum corneum. In acute promyelocytic leukaemia, it induces cellular differentiation and decreases proliferations.
Precaution
Children, hepatic or renal impairment. Reduce dose if intractable headache occurs. Discontinue temporarily if LFT exceed 5 times upper limit of normal. Monitor closely for leukocytosis or respiratory compromise. Monitor haematologic profile, coagulation parameters, LFT, serum triglyceride and cholesterol concentrations regularly.
Lactation: Unknown if excreted in breast milk; do not breast-feed, because of potential for serious adverse reactions in infant
Side Effect
>10%
Headache (86%),Fever (83%),Bone pain (77%),Dry mucous membranes (77%),Malaise (67%),URI (63%),Shivering (60%),Dyspnea (60%),Hemorrhage (60%),Elevated liver function tests (50-60%),Hyperlipidemia (60%).Infections (58%),Nausea and vomiting (57%),Rash (54%),Peripheral edema (52%),Leukocytosis (40%),Pain (37%),Abdominal pain (31%),DIC (26%),Respiratory insufficiency (26%),Mucositis (26%),GI disorder (26%),Retinoic acid-APL syndrome (25%),Ear ache (23%),Diarrhea (23%),Pleural effusion (20%),Dizziness (20%),Pruritus (20%),Sweating (20%),Anxiety (17%),Paresthesia (17%),Constipation (17%),Vision changes (17%),Dyspepsia (14%),Depression(14%),Insomnia (14%),Alopecia (14%),Skin changes (14%),Confusion (11%),Abdominal distention (11%),Renal insufficiency (11%)
1-10% (selected)
Cardiac failure,Pseudotumor cerebri,Ulcer
Potentially Fatal: Retinoic acid syndrome, cardiac arrthythmia, disseminated intravascular coagulation, blood dyscrasias, cardiac arrest, cerebral haemorrhage.
Interaction
Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides.
Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.
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