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Detrusin
Unimed Unihealth Pharmaceuticals Ltd.
Generic: Tolterodine Tartrate
Safety Advices
বাংলা
English
UNSAFE
Detrusin may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Detrusin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Detrusin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Long-term use of Detrusin might reduce milk production.
UNSAFE
Detrusin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Detrusin should be used with caution in patients with kidney disease. Dose adjustment of Detrusin may be needed. Please consult your doctor.
CAUTION
Detrusin should be used with caution in patients with liver disease. Dose adjustment of Detrusin may be needed. Please consult your doctor.
Medicine Overview of Detrusin 1mg Tablet
Introduction
Detrusin is used in the treatment of overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination. Detrusin is advised to take it in a dose and duration as per prescription. It can be taken with or without food, but take it at the same time regularly. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the...
... Show moreUses of Detrusin
- Overactive bladder (OAB) symptoms
Side effects of Detrusin
Common
- Dryness in mouth
- Constipation
- Headache
- Dizziness
- Sleepiness
- Blurred vision
- Dry skin
How to use Detrusin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Detrusin may be taken with or without food, but it is better to take it at a fixed time.
How Detrusin works
Detrusin is an antimuscarinic. It works by relaxing muscles of the urinary bladder and prevents frequent, urgent or uncontrolled urination.
What if you forget to take Detrusin?
If you miss a dose of Detrusin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Detrusin treats symptoms of an overactive bladder by lowering the urge to urinate and controlling urination.
- It can take up to 4 weeks before you see any improvement in your symptoms. Keep taking it as prescribed.
- Avoid caffeine, alcohol, and carbonated drinks as they can worsen your symptoms.
- It may cause dizziness and blurring of vision. Don't drive or do anything that requires mental focus until you know how it affects you.
- Dry mouth, dry eyes, and constipation may occur as a side effect. Maintain good oral hygiene, drink water frequently, chew sugarless gum, and wear contact lenses with caution.
Brief Description
Indication
Overactive bladder
Adult Dose
Oral
Overactive Bladder, Urge Incontinence
Immediate release: 2 mg PO q12hr. Reduce to 1 mg bid if needed to reduce side effects.
Extended release: 2-4 mg PO once daily
Hepatic impairment
Mild to moderate (Child-Pugh class A or B): Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
Severe (Child-Pugh class C): Not recommended
Child Dose
Child < 18 years: Not recommended
Renal Dose
Renal impairment
CrCl 10-30 mL/min: Not to exceed 1 mg PO q12hr (immediate release) or 2 mg PO once daily (extended release)
CrCl <10 mL/min: Not recommended
Contraindication
Severe ulcerative colitis, toxic megacolon, urinary retention, gastric retention, myasthenia gravis, uncontrolled narrow-angle glaucoma, pregnancy.
Mode of Action
Tolterodine is a competitive muscarinic receptor antagonist with actions similar to atropine. It is used in the management of urge urinary incontinence, urgency and frequency.
Precaution
Bladder flow obstruction, GI obstructive disorders, renal or hepatic impairment, autonomic neuropathy, hiatus hernia, risk of decreased GI motility, patients at risk of QT interval prolongation (e.g. electrolyte disturbances, bradycardia, pre-exisiting cardiac disorder).
Lactation: Unknown whether drug is distributed in breast milk; do not nurse
Side Effect
>10%
Dry mouth (40%)
1-10%
Blurred vision,Constipation,Dizziness,Drowsiness,Dyspepsia,Headache,Xerophthalmia
Interaction
Increased risk of overdosage with potent CYP3A4 inhibitors e.g. macrolide antibiotics (erythromycin and clarithromycin), azole antifungals (e.g. ketoconazole and itraconazole), protease inhibitors, ciclosporin or vinblastine. Increased risk of torsade de pointes with drugs that prolong the QT interval (e.g. class Ia and class III antiarrhythmics). Increased risk of 'cholinergic neurogenic hypersensitivity' with centrally acting anticholinesterases (e.g. donepezil, rivastigmine). Increased risk of antimuscarinic side effects with antimuscarinic drugs.
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