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Nocpres 100
Healthcare Pharmaceuticals Ltd.
Generic: Desmopressin
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Nocpres 100.
SAFE IF PRESCRIBED
Nocpres 100 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Nocpres 100 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Nocpres 100 does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Nocpres 100 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Nocpres 100 in patients with liver disease. Please consult your doctor.
Medicine Overview of Nocpres 100 100mcg Tablet
Introduction
Nocpres 100 is a medicine used in the treatment of diabetes insipidus and bed-wetting. It helps decrease the urge to urinate and help resume more normal life-style. Nocpres 100 can be taken in an empty stomach or after food. Your doctor will decide the dose and how often you should take them. You should use it regularly to get the most benefit from the medicine. Do not stop using the medicine even if you feel better unless the doctor tells you so. Some common side effects of this medicine include headache, stomach pain, and nausea. Let your doctor know if...
... Show moreUses of Nocpres 100
- Diabetes insipidus
- Bed-wetting
Side effects of Nocpres 100
Common
- Headache
- Nausea
How to use Nocpres 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nocpres 100 may be taken with or without food, but it is better to take it at a fixed time.
How Nocpres 100 works
Nocpres 100 is a synthetic form of vasopressin (natural hormone that balances water). It works by causing reabsorption of water from the kidneys which controls excessive thirst and urination in diabetes insipidus. It also helps decrease night-time urine production and bedwetting in children. In addition to these, it reduces bleeding episodes by promoting the release of blood clotting factors.
What if you forget to take Nocpres 100?
If you miss a dose of Nocpres 100, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- You have been prescribed Nocpres 100 for the treatment of diabetes insipidus and/or bed-wetting.
- Limit the amount of fluids you drink with this medication.
- Nocpres 100 can cause low sodium levels in your body. Get regular blood tests done to monitor the levels.
- Inform your doctor if you develop an infection, fever, diarrhea, or vomiting.
- Talk to your doctor if you have sudden weight gain or swelling in your arms and legs that does not go away.
Brief Description
Indication
Diabetes Insipidus, Hemophilia A, Von Willebrand Disease (Type 1), Nocturnal Enuresis, Nocturia, Uremic Bleeding in Acute or Chronic Renal Failure
Administration
May be taken with or without food.
IV infusion: Dilute in 10 mL or 50 mL of NaCl 0.9% inj.
Adult Dose
Diabetes Insipidus Intranasal Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery 10-40 mcg (0.1-0.4 mL) qDay, either as a single dose or divided into 2 or 3 doses; usual dose is 20 mcg (0.2 mL) qDay in 2 divided doses Adjust morning and evening doses separately for an adequate diurnal rhythm of water turnover PO Initial: 0.05 mg q12hr Effective range: 0.1-1.2 mg divided q8-12hr Observe fluid restriction If switching to PO from intranasal, start PO at least 12 hours after...
... Show moreChild Dose
Diabetes Insipidus Nasal spray Indicated as antidiuretic replacement therapy in the management of central cranial diabetes insipidus and for management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region in patients (>3 months) 12 years 10-40 mcg (0.1-0.4 mL) qDay, either as a single dose or divided into 2 or 3 doses; usual dose is 20 mcg (0.2 mL) qDay in 2 divided doses Adjust morning and evening doses separately for an adequate diurnal rhythm of water turnover Nocturnal Enuresis >6 years: 0.2 mg PO qHS (up to 0.6 mg/day) Hemophilia A & Von...
... Show moreRenal Dose
Renal impairment
CrCl 50 mL/min: No adjustments necessary
Contraindication
Cardiac insufficiency w/ ongoing diuretic treatment. Patient w/ habitual and psychogenic polydipsia, hyponatraemia or history of hyponatraemia. Moderate to severe renal impairment (CrCl <50 mL/min).
Mode of Action
Desmopressin increases cyclic adenosine monophosphate (cAMP) in renal tubular cells which increases water permeability resulting in reduced urine volume and enhanced urine osmolality. It also stimulates factor VII and plasminogen activator activity in the blood, but w/ minimal pressor activity.
Onset: Antidiuretic: Approx 60 min (oral); 15-30 min (intranasal).
Precaution
Patient w/ CV disease or cystic fibrosis, coronary artery insufficiency, at risk for increased intracranial pressure, predisposed to thrombus formation. Elderly and childn. Pregnancy and lactation.
Side Effect
>10%
Dry mouth, men (14%)
Dry mouth, women (12%)
1-10%
Headache (2-5%)
Hyponatremia, men (4%)
Headache, men (4%)
Hyponatremia, women (3%)
Dizziness, men (3%)
Dizziness (3%)
Epistaxis (2-3%)
Headache, women (2%)
Dizziness, women (2%)
Nasal spray
Rhinitis (3-8%)
Abdominal pain (2%)
Asthenia (2%)
Chills (2%)
Nostril pain (2%)
Gastrointestinal disorder (2%)
Nausea (2%)
Conjunctivitis (2%)
Eye edema (2%)
Lachrymation disorder (2%)
Frequency Not Defined
Abnormal blood pressure (infrequent)
Increased heart rate
Increased blood pressure
Flushing
Seizure (rare)
Hyponatremia
Hyposmolality (rare)
Water intoxication syndrome
Thromboembolic disorder
Allergic reaction (acute)
Anaphylaxis (rare)
Pregnancy Category Note
Pregnancy Prolonged experience with desmopressin in pregnant women over several decades, based on available published data and case reports, did not identify a drug associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; in addition, in vitro studies with human placenta demonstrate poor placental transfer of desmopressin; no adverse developmental outcomes were observed in animal reproduction studies with administration of desmopressin during organogenesis to pregnant rats and rabbits at doses approximately <1 and 38 times, respectively, the maximum recommended human dose based on body surface area (mg/m²) Not recommended for treatment of nocturia in pregnant women;...
... Show moreInteraction
May enhance antidiuretic effect w/ NSAIDs (e.g. ibuprofen), indometacin, TCAs, chlorpromazine, carbamazepine, SSRIs, opiates, lamotrigine. May reduce antidiuretic effect w/ lithium, epinephrine (large dose), heparin, demeclocycline.
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