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Faslodex 250
MGH Healthcare Limited
Generic: Fulvestrant
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Faslodex 250. Please consult your doctor.
CONSULT YOUR DOCTOR
Faslodex 250 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Faslodex 250 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Faslodex 250 does not usually affect your ability to drive.
CAUTION
Faslodex 250 should be used with caution in patients with severe kidney disease. Dose adjustment of Faslodex 250 may be needed. Please consult your doctor.
Limited information is available on the use of Faslodex 250 in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
CAUTION
Faslodex 250 should be used with caution in patients with liver disease. Dose adjustment of Faslodex 250 may be needed. Please consult your doctor.
Medicine Overview of Faslodex 250mg/5ml Injection
Introduction
Faslodex 250 is an estrogen blocker. It is used in the treatment of breast cancer in women who have gone through menopause. It works by adjusting the level of estrogen and slow down the growth of cancer cells. Faslodex 250 is given as an injection into the muscles under the supervision of a doctor. It should be taken as doctor your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as...
... Show moreUses of Faslodex 250
- Breast cancer
Side effects of Faslodex 250
Common
- Headache
- Vomiting
- Weakness
- Allergic reaction
- Nausea
- Injection site reaction
- Urinary tract infection
- Diarrhea
How to use Faslodex 250
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Faslodex 250 works
Faslodex 250 blocks the action of estrogen on breast cancer cells. This can lower or stop the growth of some breast cancer cells that need estrogen to grow.
What if you forget to take Faslodex 250?
If you miss a dose of Faslodex 250, please consult your doctor.
Quick Tips
- Faslodex 250 is used for the treatment of hormone dependent breast cancer.
- It should only be taken by women who have undergone menopause and cannot become pregnant.
- It is given as a slow injection into the muscles (intramuscular) of your buttock.
- Inform your doctor if you have any bleeding disorder, kidney or liver disease or if you are receiving any medicines to prevent blood clots.
- Do not take Faslodex 250 if you are pregnant or breastfeeding.
Brief Description
Indication
Metastatic breast cancer, in postmenopausal women w/ oestrogen-receptor positive tumours.
Adult Dose
Intramuscular
Metastatic breast cancer in postmenopausal women with oestrogen-receptor positive tumours
Adult: 500 mg (250 mg into each buttock) on days 1, 15, and 29, then once monthly thereafter.
Moderate (Child-Pugh Class B): 250 mg (into 1 buttock) on days 1, 15, and 29, then once monthly thereafter.
Severe: Contraindicated.
Renal Dose
Renal impairment
Negligible amounts of fulvestrant are eliminated in urine
In clinical trials, fulvestrant concentrations in women with eCrCl ?30 mL/min were similar to women with normal creatinine
Contraindication
Pregnancy and lactation.
Mode of Action
Fulvestrant competitively binds to oestrogen receptors, forming a nuclear complex, leading to down-regulation of oestrogen receptor protein levels and inhibition of tumour growth.
Precaution
Patient w/ bleeding diatheses, thrombocytopenia. Admin at dorsogluteal inj site. Mild to moderate hepatic and severe renal (CrCl <30 mL/min) impairment.
Side Effect
>10%
Nausea (26%)
Asthenia (23%)
Pain (19%)
Vasodilatation (18%)
Pharyngitis (16%)
HA (15%)
Back pain (14%)
Constipation (13%)
Vomiting (13%)
Abd pain (12%)
Diarrhea (12%)
Inj site pain (11%)
1-10%
Cough (10%)
Anorexia (9%)
Peripheral edema (9%)
Chest pain (7%)
Flu-like syndrome (7%)
Rash (7%)
Depression (6%)
Fever (6%)
UTI (6%)
Anemia (5%)
<1%
Angioedema
Leukopenia
Myalgia
Thrombosis
Osteoporosis
Interaction
Increased risk of bleeding when taken concomitantly w/ anticoagulants.
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