12-24 Hours
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Graftcept
Healthcare Pharmaceuticals Ltd.
Generic: Mycophenolate Mofetil
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Graftcept does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Graftcept is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Graftcept is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Graftcept does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Graftcept is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Graftcept may not be needed in these patients. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Graftcept in patients with liver disease. Please consult your doctor.
Medicine Overview of Graftcept 500mg Tablet
Introduction
Graftcept belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body from rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by supressing your body’s immune system, so that it does not attack the new organ. The amount of Graftcept you take and how often you take it depends on the type of transplant you have. Follow your doctor's instructions on this. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow it as a whole,...
... Show moreUses of Graftcept
- Prevention of organ rejection in transplant patients
Side effects of Graftcept
Common
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- High blood pressure
- Decreased white blood cell count (neutrophils)
How to use Graftcept
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Graftcept may be taken with or without food, but it is better to take it at a fixed time.
How Graftcept works
Graftcept is an immunosuppressant. It reduces the action of body's own defence system (the immune system) and prevents rejection of the transplanted organ.
Quick Tips
- Your doctor has prescribed Graftcept to stop your body from rejecting a transplanted organ (e.g. kidney, heart or liver).
- It may take 6 to 12 weeks for Graftcept to start working. Keep taking it as prescribed.
- It may cause birth defects so birth control is required in females with reproductive potential.
- It makes you more susceptible to getting infections. Avoid contact with people who have an infection. Consult your doctor immediately if you develop a sore throat, high temperature, any other signs of infections.
- Protect yourself from direct sunlight by wearing protective clothing and applying a sunscreen with a high sun protection factor (SPF).
- Take it with food to minimize possible side effects like nausea and stomach pain.
- Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, or fever.
Brief Description
Indication
Prophylaxis of acute renal graft rejection, Prophylaxis of cardiac graft rejection, Liver Transplant
Administration
Drug is taken on empty stomach 1 hour before or 2 hours after meals
Once dosage is stabilized, MMF can be taken with food after kidney transplant
Adult Dose
Oral
Adult
Prophylaxis of acute renal graft rejection
As Mycophenolate Mofetil (MMF): 1 g twice daily starting w/in 72 hr of transplantation. Max: 2 g/day.
Prophylaxis of cardiac graft rejection, Liver Transplant
Adult:
As Mycophenolate Mofetil (MMF):1.5 g bid starting within 5 days after transplantation.
Child Dose
3 months
Prophylaxis of organ rejection in patients receiving allogeneic renal transplants
As Mycophenolate Mofetil (MMF):
MMF (suspension): 600 mg/m² PO q12hr; not to exceed 2 g/day
MMF: BSA 1.25-1.5 m²: 750 mg capsule PO q12hr
MMF: BSA >1.5 m²: 1 g capsule/tablet PO q12hr
Renal Dose
Renal impairment
MMF: In severe renal impairment (glomerular filtration rate [GFR] <25 mL/min/1.73 m²), not to exceed 1 g q12hr
No dosage adjustment needed in renal transplant patients experiencing delayed graft function post-operatively.
Contraindication
Pregnancy, lactation. Rare hereditary deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), including Kelley-Seegmiller or Lesch-Nyhan syndrome.
Mode of Action
Mycophenolic acid acts by blocking purine synthesis of human lymphocytes through reversible inhibition of inosine monophosphate dehydrogenase. It also inhibits proliferation of both T- and B- lymphocytes.
Precaution
Teratogenic in animals; avoid inhalation or direct skin contact. Monitor patients for lymphoproliferative disorders; advise patient to limit exposure to sunlight/UV light. Perform CBCs; monitor for neutropenia.
Mycophenolate mofetil and mycophenolate sodium are not interchangeable.
Lactation: Unknown whether drug is excreted in breast milk; avoid using, or do not nurse
Side Effect
>10%
Hyperglycemia (44%),Hypercholesterolemia (41%),Hypomagnesemia (39%),Dyspnea (37%),Back pain (35%),Increased blood urea nitrogen (BUN) (35%),Leukopenia (34%),Pleural effusion (34%),Urinary tract infection (34%),Increasing frequency of cough (31%),Hypocalcemia (30%),Hypertension (28%),Abdominal pain (27%),Peripheral edema (27%),Anemia (26%),Fever (23%),Nausea (23%),Hyperkalemia (22%),Diarrhea (21%),Infection (21%),Headache (16%)
1-10%
Melanoma (1.6-4.2%),Other malignancies (0.7-2.1%),Lymphoma (0.4-1%),Opportunistic infection (including herpes),Neutropenia,GI bleeding,Pulmonary fibrosis,Progressive multifocal leukoencephalopathy
Potentially Fatal: Angioedema, anaphylaxis, fatal pulmonary fibrosis.
Interaction
Increased plasma levels of both drugs when combined with aciclovir, valaciclovir, ganciclovir and valganciclovir. Reduced absorption with colestyramine, magnesium- and aluminium hydroxide-containing products, sevelamer and other calcium-free phosphate binders. Reduced plasma levels with ciclosporin, metronidazole, quinolones, rifamycins. May reduce plasma levels of progestins; may reduce efficacy of oral contraceptives. Increased plasma levels with probenecid. May reduce efficacy of live vaccines.
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