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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Diaryl 1.
CONSULT YOUR DOCTOR
Diaryl 1 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Diaryl 1 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with Diaryl 1
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Diaryl 1 should be used with caution in patients with kidney disease. Dose adjustment of Diaryl 1 may be needed. Please consult your doctor.
Use of Diaryl 1 is not recommended in patients with severe kidney disease. These patients can experience very low blood sugar levels which may become normal after a long time.
CAUTION
Diaryl 1 should be used with caution in patients with liver disease. Dose adjustment of Diaryl 1 may be needed. Please consult your doctor.
Use of Diaryl 1 is not recommended in patients with severe liver disease. These patients can experience very low blood sugar levels which may become normal after a long time.
Medicine Overview of Diaryl 1mg Tablet
Introduction
Diaryl 1 is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Diaryl 1 may be used alone or along with other medicines. It should be taken just before or with the first meal of the day. Take it regularly at the same time each day to get the maximum benefit. Your doctor will decide what dose is best for you and this may change from...
... Show moreUses of Diaryl 1
- Type 2 diabetes mellitus
Side effects of Diaryl 1
Common
- Hypoglycemia (low blood glucose level)
- Headache
- Nausea
- Dizziness
How to use Diaryl 1
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diaryl 1 is to be taken with food.
How Diaryl 1 works
Diaryl 1 is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.
What if you forget to take Diaryl 1?
You should skip a dose of Diaryl 1 if a meal is skipped, and add a dose of medicine if you eat an extra meal.
Quick Tips
- Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
- Exercise regularly, eat a healthy diet and take your other diabetes medicines (if prescribed) alongside.
- Monitor your blood sugar level regularly while you are taking this medicine.
- Be careful while driving or operating machinery until you know how Diaryl 1 affects you.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Brief Description
Indication
Type 2 DM
Administration
Should be taken with food. Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Initially, 1-2 mg daily. May be increased in increments of 1-2 mg at intervals of 1-2 wk. Maintenance: 4 mg daily. Max: 6 mg daily.
Elderly: Initially, 1 mg once daily.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: 1 mg PO qDay; titrate dose based on fasting blood glucose levels
Severe: Contraindicated.
Contraindication
Diabetic ketoacidosis with or without coma.
Mode of Action
Glimepiride stimulates the insulin release from pancreatic beta-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.
Precaution
Increased risk of CV mortality. Elderly; hepatic and renal impairment. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in patients with CHF or hepatic cirrhosis. Monitor blood-glucose concentration. Pregnancy, lactation.
Lactation: Excretion in milk unknown; avoid
Side Effect
>10%
Hypoglycemia (4-20%)
1-10%
Dizziness (1.7%),Asthenia (1.6%),Headache (1.5%),Nausea (1.1%)
<1%
Allergic skin reactions,Erythema,Morbilliform or maculopapular eruptions,Pruritus,Urticaria,Diarrhea,Gastrointestinal pain,Vomiting,Agranulocytosis,Anemia,Aplastic anemia,Leukopenia,Pancytopenia,Thrombocytopenia, hemolytic,Cholestasis,Elevation of liver enzyme levels,Hepatic porphyria reactions,Jaundice (rare),Disulfiram-like reactions,Hyponatremia
Interaction
Salicylates, sulfonamides, chloramphenicol, clarithromycin, coumarin anticoagulants, probenecid, CYP2C9 inhibitors, fibric acid derivatives, disopyramide, fluoxetine, quinolones, ACE inhibitors, MAOIs and ?-blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, phenytoin, nicotinic acid, sympathomimetics and CYP2C9 inducers may reduce hypoglycaemic effect of glimepiride. Reduced plasma concentration w/ colesevelam.
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