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Safety Advices
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UNSAFE
Modecate may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Modecate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Modecate is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
If Modecate is given, monitor the baby for excessive sleepiness.
UNSAFE
Modecate may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Caution is advised when driving or operating machinery.
CONSULT YOUR DOCTOR
There is limited information available on the use of Modecate in patients with kidney disease. Please consult your doctor.
CAUTION
Modecate should be used with caution in patients with liver disease. Dose adjustment of Modecate may be needed. Please consult your doctor.
Medicine Overview of Modecate 25mg\ml Injection
Introduction
Modecate is a prescription medicine used in the treatment of schizophrenia. It may also be used to treat depression and bipolar disorder. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Modecate is given as an injection under the supervision of a healthcare professional and should not be self administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take...
... Show moreUses of Modecate
- Schizophrenia
Side effects of Modecate
Common
- Abnormality of voluntary movements
- Constipation
- Dryness in mouth
- Increased prolactin level in blood
- Injection site reactions (pain, swelling, redness)
- Muscle stiffness
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Tremor
- Urinary retention
- Weight gain
How to use Modecate
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Modecate works
Modecate is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
- It makes you feel sleepy. Do not drive or do anything requiring mental focus until you know how it affects you.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
In the long-term management of psychotic disorders including, Schizophrenia, Mania, Organic brain syndrome
Adult Dose
Intramuscular
Psychoses; Mania; Schizophrenia
Adult: As decanoate: Initially, 12.5 mg adjusted according to response. Maintenance: 12.5-100 mg at intervals of 2-6 wk. For doses >50 mg, increments should be made slowly in steps of 12.5 mg.
Elderly: 6.25 mg adjusted according to response.
Hepatic impairment: Use with caution; monitor
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Use with caution; monitor
Contraindication
Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.
Mode of Action
Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It reduces aggressiveness with disappearance of hallucinations and delusions.
Precaution
Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.
Lactation: Drug enters breast milk; not recommended
Side Effect
Frequency Not Defined
Confusion,Decreased gag reflex
Extrapyramidal symptoms
Akathisia,Dystonia,Dyskinesia,Muscle stiffness,Neuroleptic malignant syndrome (NMS; infrequent but serious),Parkinsonism,Tardive dyskinesia
Common
Anticholinergic effects,Sedation,Weight gain,Erectile dysfunction,Oligomenorrhea or amenorrhea,
Less common
Orthostatic hypotension (after IM injection), tachycardia,Agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, poikilothermia, restlessness, weakness,Anorexia, constipation, dyspepsia, ileus,Lens opacities (with prolonged use)
Uncommon
ECG changes,Photosensitivity,Pruritus,Diarrhea,Blood dyscrasia,Galactorrhea,Ejaculatory disorder
Rare
Seizure,Priapism,Cholestatic jaundice
Interaction
Reduces antihypertensive effects of guanethidine, methyldopa and clonidine. Lithium toxicity. Reduced bioavailability with antacids. Increased risk of arrhythmia when used with drugs that prolong QT interval. May cause electrolyte disturbance when used with diuretics.
Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.