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Linera M 500
Ziska Pharmaceuticals Ltd.
Generic: Linagliptin + Metformin Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Linera M 500.
SAFE IF PRESCRIBED
Linera M 500 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Linera M 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Linera M 500 should be used with caution in patients with kidney disease. Dose adjustment of Linera M 500 may be needed. Please consult your doctor.
Use of Linera M 500 is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
CAUTION
Linera M 500 should be used with caution in patients with liver disease. Dose adjustment of Linera M 500 may be needed. Please consult your doctor.
Linera M 500 is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Medicine Overview of Linera M 500 2.5mg+500mg Tablet
Introduction
Linera M 500 is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chance of having a heart attack or stroke. Linera M 500 can be prescribed alone or together with other diabetes medications. All diabetes medicines work best when used along with a healthy diet and regular exercise. The dose you are given will depend on your condition, blood sugar levels and what other medicines you are taking. Taking this medicine with meals...
... Show moreUses of Linera M 500
- Type 2 diabetes mellitus
Side effects of Linera M 500
Common
- Diarrhea
- Nausea
- Vomiting
- Upset stomach
- Headache
- Nasal congestion (stuffy nose)
- Sore throat
- Respiratory tract infection
- Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea
How to use Linera M 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Linera M 500 is to be taken with food.
How Linera M 500 works
Linera M 500 is a combination of two antidiabetic medicines: Metformin and Linagliptin. Metformin is an antidiabetic medication (biguanide). It works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Linagliptin is a DPP-4 inhibitor which works by increasing the release of insulin from the pancreas and decreasing the hormones that raise blood sugar levels. This reduces both fasting and postmeal sugar levels. Together, they provide better control of blood sugar.
What if you forget to take Linera M 500?
If you miss a dose of Linera M 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Trajenta Duo 2.5mg/500mg Tablet should be taken with food to lower the chances of having an upset stomach.
- Take it in addition to regular exercise and a healthy diet to lower the levels of blood sugar.
- Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines.
- Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.
- Monitor your blood sugar level regularly while you are taking this medicine.
- Inform your doctor about your diabetes treatment if you are due to have any surgery under a general anaesthetic.
- Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting or stomach pain as Trajenta Duo 2.5mg/500mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.
Brief Description
Indication
Type 2 Diabetes mellitus
Administration
Should be taken with meals to reduce the gastrointestinal undesirable effects associated with metformin.
Adult Dose
Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both linagliptin and metformin is appropriate. Prompt-release tablets Initial dose (not currently taking metformin): 2.5 mg/500 mg PO BID Initial dose (already taking metformin): Base dose on current metformin dose (eg, if taking metformin 1000 mg BID, initiate with 2.5 mg/1000 mg PO BID) Not to exceed 2.5 mg/1,000 mg BID Extended-release tablets Individualize dose on the basis of both effectiveness and tolerability, while not exceeding the maximum recommended total daily dose of linagliptin/metformin 5 mg/2000 mg Initial...
... Show moreChild Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment
Obtain eGFR before starting metformin
eGFR <30 mL/min/1.73 m²: Contraindicated
eGFR 30-45 mL/min/1.73 m²: Not recommended to initiate treatment
Monitor eGFR at least annually or more often for those at risk for renal impairment (eg, elderly)
If eGFR falls below 45mL/min/1.73 m² while taking metformin, risks and benefits of continuing therapy should be evaluated
If eGFR falls below 30 mL/min/1.73 m²: while taking metformin, discontinue the drug
Contraindication
Hypersensitivity. Type 1 diabetes, diabetic ketoacidosis or pre-coma, renal failure or dysfunction (CrCl <60 mL/min), hepatic insufficiency, acute alcohol intoxication, alcoholism. Acute conditions w/ the potential to alter renal function eg dehydration, severe infection, shock, IV administration of iodinated contrast agents. Acute or chronic diseases which may cause tissue hypoxia eg cardiac or resp failure, recent MI. Lactation.
Mode of Action
Linagliptin: Dipeptidyl peptidase 4 (DPP-4) inhibitor; increases and prolongs incretin hormone activity from glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) which are inactivated by the DPP-4 enzyme; incretins increase insulin release and reduce glucagon secretion
Metformin: Decreases hepatic glucose production; decreases GI intestinal glucose absorption; increases target cell insulin sensitivity; lowers both basal and postprandial plasma glucose and unlike sulfonylureas, does not typically produce hypoglycemia or hyperinsulinemia
Precaution
Monitor for pancreatitis, hypoglycaemia, lactic acidosis, renal impairment. Intravascular administration of iodinated contrast agents. Co-administration of insulin. Discontinue treatment 48 hr before elective surgery w/ general, spinal or peridural anaesth. Evaluate serum electrolytes & ketones, blood glucose & if indicated, blood pH, lactate, pyruvate & metformin levels in patients w/ previously well controlled type 2 diabetes on Trajenta Duo who develops laboratory abnormalities or clinical illness. Pregnancy. Childn & adolescents <18 yr. Elderly. Lactation: Metformin excreted in human milk in low concentrations; unknown if linagliptin excreted in human milk No studies in lactating animals have been conducted with the combined...
... Show moreSide Effect
>10%
Hypoglycemia (with sulfonylurea) (22.9%)
1-10%
Nasopharyngitis (6.3%),Diarrhea (6.3%),Hypoglycemia (without sulfonylurea) (1.4%)
Frequency Not Defined
Hypersensitivity (eg, urticaria, angioedema, or bronchial hyperactivity),Cough,Decreased appetite,Nausea,Vomiting,Pruritus,Pancreatitis
Interaction
Linagliptin: Inhibits P-glycoprotein-mediated transport of digoxin (w/ low potency). Increased AUC & Cmax w/ ritonavir. Decreased steady-state AUC & Cmax, & DPP-4 inhibition at trough w/ rifampicin. Weakly inhibits CYP3A4-mediated metabolism (eg simvastatin).
Metformin: Increased risk of lactic acidosis in acute alcohol intoxication. Competition on common renal tubular transport systems w/ cationic agents eliminated by renal tubular secretion (eg cimetidine). Risk of renal failure & lactic acidosis w/ intravascular administration of iodinated contrast agents.
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