12-24 Hours
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Trusert HZ 40/12.5
Ziska Pharmaceuticals Ltd.
Generic: Hydrochlorothiazide + Telmisartan
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Trusert HZ 40/12.5. Please consult your doctor.
CONSULT YOUR DOCTOR
Trusert HZ 40/12.5 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Trusert HZ 40/12.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Trusert HZ 40/12.5 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Trusert HZ 40/12.5 should be used with caution in patients with severe kidney disease. Dose adjustment of Trusert HZ 40/12.5 may be needed. Please consult your doctor.
Use of Trusert HZ 40/12.5 is not recommended in patients with severe kidney disease.
CAUTION
Trusert HZ 40/12.5 should be used with caution in patients with liver disease. Dose adjustment of Trusert HZ 40/12.5 may be needed. Please consult your doctor.
Medicine Overview of Trusert HZ 40/12.5 40mg/12.5mg Tablet
Introduction
Trusert HZ 40/12.5 contains two medicines, both of which help to control high blood pressure. It is generally used when one medicine alone is not controlling the blood pressure effectively. Lowering blood pressure helps to reduce your risk of having a heart attack or a stroke in the future. You can take Trusert HZ 40/12.5 with or without food. The dose will depend on your condition and how you respond to the medicine. Try to take it at the same time each day. It's important to keep taking this medicine until your doctor tells you not to. It contains a...
... Show moreUses of Trusert HZ 40/12.5
- Hypertension (high blood pressure)
Side effects of Trusert HZ 40/12.5
Common
- Fatigue
- Dizziness
- Nausea
- Diarrhea
- Sinus inflammation
- Flu-like symptoms
- Upper respiratory tract infection
How to use Trusert HZ 40/12.5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trusert HZ 40/12.5 may be taken with or without food, but it is better to take it at a fixed time.
How Trusert HZ 40/12.5 works
Trusert HZ 40/12.5 is a combination of two medicines: Telmisartan and hydrochlorothiazide which lowers the blood pressure effectively. Telmisartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin, thereby relaxing the blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- It can be taken with or without food.
- Trusert HZ 40/12.5 may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Trusert HZ 40/12.5 during pregnancy or breastfeeding is unsafe.
Brief Description
Indication
Hypertension, Diabetic nephropathy
Administration
May be taken with or without food.
Adult Dose
Oral
Hypertension
Adult 1 tab (40-80 mg telmisartan/12.5-25 mg) once daily.
Max: Telmisartan 160 mg & hydrochlorothiazide 25 mg daily.
Hepatic Impairment
Initiate therapy with low dose; titrate slowly; monitor
Renal Dose
Renal impairment
Dose adjustment not necessary
Hemodialysis patients are more susceptible to hypotension
Contraindication
Severe hepatic impairment, biliary obstructive disorders. Pregnancy. Lactation.
Mode of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Telmisartan is a nonpeptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II.
Precaution
Hepatic insufficiency, biliary obstruction, renal impairment, renaly artery stenosis. Correct volume depletion before initiating treatment. Monitor serum potassium levels regularly, especially in elderly and renally-impaired patients.
Lactation: discontinue drug or do not nurse
Side Effect
1-10%
Telmisartan
Upper respiratory infection (7%),Urinary tract infection (1%),Back pain (3%),Diarrhea (3%),Myalgia (3%),Fatigue (1%),Sinusitis (3%),Peripheral edema (1%),Chest pain (1%),Hypertension (1%),Dyspepsia (1%),Headache (1%),Dizziness (1%),Pharyngitis (1%)
Frequency Not Defined
Hydrochlorothiazide
Anorexia,Epigastric distress,Hypotension,Orthostatic hypotension,Photosensitivity,Anaphylaxis,Anemia,Confusion,Erythema multiforme,Stevens-Johnson syndrome,Exfoliative dermatitis including toxic epidermal necrolysis,Dizziness,Hypokalemia and/or hypomagnesemia,Hyperuricemia
Potentially Fatal: Rarely angioedema, rash, pruritus and urticaria.
Pregnancy Category Note
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)
Interaction
Lithium, kaliuretic diuretics, laxatives, corticosteroids, ACTH, amphotericin, carbenoxolone, penicillin G, salicylates, K-sparing diuretics, K supplements, K salt substitutes drugs that cause hyperkalaemia, digitalis glycosides, antiarrhythmic agents, drugs known to induce torsades de pointes, alcohol, barbiturates, narcotics, oral antidiabetics, insulin, anion-exchange resins, NSAIDs, nondepolarising skeletal muscle relaxants, pressor amines, allopurinol, Ca salts, beta-blockers, diazoxide, anticholinergics, amantadine, cytotoxics.
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