1-10% Headache (7.2%),Drowsiness (1.3%),Fatigue (1.3%) Frequency Not Defined CNS depression,Sedation ranging from mild drowsiness to deep sleep (most frequent),Dizziness,Lassitude,Disturbed coordination,Muscular weakness,Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common,Epigastric distress,Anorexia,Nausea,Vomiting,Diarrhea,Constipation,Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare,Tachycardia, palpitation ECG changes (eg, widened QRS). Arrhythmias (eg, extrasystole, heart block),Hypotension,Hypertension,Dizziness, sedation, and hypotension may occur in geriatric patients,Dryness of mouth, nose, and throat,Dysuria,Urinary retention,Impotence,Vertigo,Visual disturbances,Blurred vision,Diplopia; tinnitus,Acute labyrinthitis,Tremors,Nervousness,Irritability,Facial dyskinesia,Tightness of the chest,Thickening of bronchial secretions,Wheezing,Nasal stuffiness,Sweating,Chills,Early menses,Toxic psychosis,Faintness,Paresthesia,Agranulocytosis,Hemolytic anemia,Leukopenia,Thrombocytopenia,Pancytopenia,Dysmenorrhea,Dyspepsia,Fatigue,Ischemic colitis (pseudoephedrine)