12-24 Hours
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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Endosis. Please consult your doctor.
UNSAFE
Endosis is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Endosis is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Nonhormonal and progestin-only contraceptives are preferred in breastfeeding women, especially during the first 4 weeks postpartum
SAFE
Endosis does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Endosis in patients with kidney disease. Please consult your doctor.
CAUTION
Endosis should be used with caution in patients with liver disease. Dose adjustment of Endosis may be needed. Please consult your doctor.
Medicine Overview of Endosis 2mg Tablet
Introduction
Endosis is used for the treatment of pelvic pain associated with endometriosis. It consists of progestin, which is similar to the female hormone and works by suppressing the production of hormone causing endometrium. Endosis can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. Swallow the tablets whole with a drink of water. You should...
... Show moreUses of Endosis
- Endometriosis
Side effects of Endosis
Common
- Acne
- Headache
- Depression
- Breast discomfort
How to use Endosis
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Endosis may be taken with or without food, but it is better to take it at a fixed time.
How Endosis works
Endosis is a progestin (female hormone). It works by suppressing the production of estradiol, a hormone that causes excessive growth of the endometrium.
Quick Tips
- You have been prescribed Endosis for the treatment of pelvic pain associated with endometriosis.
- Take it without any break, preferably at the same time everyday.
- Do not use hormonal contraceptives while taking this medicine. If required, use non-hormonal methods of contraception such as condoms.
- You may experience infrequent or irregular menstrual bleeding patterns. Consult your doctor if this bothers you.
- Do not use Endosis if you are pregnant or breastfeeding.
Brief Description
Indication
Treatment of endometriosis.
Administration
May be taken with or without food.
Adult Dose
1 tab daily w/o interruption, taken preferably at the same time each day.
Contraindication
Hypersensitivity. Active venous thromboembolic disorder. Presence or history of arterial & CV disease (eg MI, CVA, ischemic heart disease); severe hepatic disease as long as liver function values have not returned to normal; benign or malignant liver tumors. DM w/ vascular involvement; known or suspected sex hormone-dependent malignancies; undiagnosed vag bleeding. Pregnancy. Childn prior to menarche.
Mode of Action
Dienogest is a nortestosterone derivative with no androgenic but rather an antiandrogenic activity of approximately 1/3 of that of cyproterone acetate. Dienogest binds to the progesterone receptor of the human uterus with only 10% of the relative affinity of progesterone. Despite its low affinity to the progesterone receptor, dienogest has a strong progestogenic effect in vivo. Dienogest has no significant androgenic, mineralocorticoid or glucocorticoid activity in vivo. Dienogest acts on endometriosis by reducing the endogenous production of estradiol and thereby suppressing the trophic effects of estradiol on both the eutopic and ectopic endometrium. When given continuously, dienogest leads to a...
... Show morePrecaution
Obtain a complete medical history & perform physical & gynecological exam prior to initiation or reinstitution of therapy. Patients w/ history of extrauterine pregnancy or impairment of tube function, depression, chloasma gravidarum, gestational DM. Increased risk of MI or cerebral thromboembolism, DVT, pulmonary embolism; breast cancer, hepatic tumor. Adenomyosis uteri or uterine leiomyomata; recurrence of cholestatic jaundice &/or pruritus; persistent ovarian follicles. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Lactation. Adolescents (menarche to 18 yr).
Side Effect
Increased wt; depressed mood, sleep disorder, nervousness, loss of libido, altered mood; headache, migraine; nausea, abdominal pain or distension, flatulence, vomiting; acne; alopecia; back pain; breast discomfort, ovarian cyst, hot flush, uterine/vag bleeding including spotting; asthenic conditions, irritability.
Interaction
Increased clearance w/ enzyme inducers eg phenytoin, barbiturates, primidone, carbamazepine, rifampicin; oxcarbazepine, topiramate, felbamate, griseofulvin, nevirapine, St. John's wort-containing products. Increased plasma levels w/ enzyme inhibitors eg ketoconazole, itraconazole, fluconazole; cimetidine, verapamil; erythromycin, clarithromycin, roxithromycin; diltiazem; ritonavir, saquinavir, indinavir, nelfinavir; nefazodone, fluvoxamine, fluoxetine; grapefruit juice.
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