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Vesifen 5
Nuvista Pharma Ltd
Generic: Solifenacin Succinate
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Vesifen 5. Please consult your doctor.
CONSULT YOUR DOCTOR
Vesifen 5 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Vesifen 5 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Long-term use of Vesifen 5 might reduce milk production, and cause constipation, dry mouth and urine infection in the baby.
UNSAFE
Vesifen 5 may cause side effects which could affect your ability to drive.
Vesifen 5 may cause blurred vision and sometimes sleepiness or tiredness which may affect your ability to drive.
CAUTION
Vesifen 5 should be used with caution in patients with severe kidney disease. Dose adjustment of Vesifen 5 may be needed. Please consult your doctor.
Use of Vesifen 5 is not recommended in patients undergoing kidney dialysis.
CAUTION
Vesifen 5 should be used with caution in patients with liver disease. Dose adjustment of Vesifen 5 may be needed. Please consult your doctor.
Use of Vesifen 5 is not recommended in patients with severe liver disease.
Medicine Overview of Vesifen 5mg Tablet
Introduction
Vesifen 5 is a muscarinic antagonist that is used in the treatment of overactive bladder. It relieves urinary symptoms like frequent urination, urgent need to urinate and inability to control urination. Vesifen 5 is advised to take it in a dose and duration as per prescription. It can be taken with or without food. Swallow the medicine as a whole without crushing or chewing it. You should not stop taking the medicine without consulting the doctor as it may lead to the worsening of your symptoms. The course of the treatment should be completed for better efficacy of the medicine....
... Show moreUses of Vesifen 5
- Overactive bladder (OAB) symptoms
Side effects of Vesifen 5
Common
- Dryness in mouth
- Constipation
- Blurred vision
- Nausea
- Upset stomach
- Urinary tract infection
How to use Vesifen 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vesifen 5 may be taken with or without food, but it is better to take it at a fixed time.
How Vesifen 5 works
Vesifen 5 is an antimuscarinic. It works by relaxing muscles of the urinary bladder to prevent frequent, urgent or uncontrolled urination.
What if you forget to take Vesifen 5?
If you miss a dose of Vesifen 5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Vesifen 5 helps you to have better control over your urination by relaxing your bladder which increases its capacity to hold urine, thereby reducing the need to pass urine.
- It may cause blurred vision, fatigue and sleepiness. Be cautious while driving or doing anything that requires focus.
- It may cause dry mouth. Try chewing on sugar-free gum or taking small sips of water.
- Avoid caffeine, alcohol or carbonated drinks as they can worsen your symptoms.
- Do not stop taking this medicine if you do not notice an improvement in your symptoms as it may take some time for your bladder to adapt and your symptoms to improve.
Brief Description
Indication
Overactive bladder
Administration
May be taken with or without food. Swallow whole, do not chew/crush.
Adult Dose
Oral
Overactive bladder
Adult: 5 mg once daily. If well tolerated, may increase to 10 mg once daily if needed. For patients who are concurrently taking CYP3A4 inhibitors (e.g. ketoconazole, ritonavir): Max dose: 5 mg once daily.
Hepatic impairment: Child-pugh class B: Max: 5 mg daily; Child-pugh class C: Use is not recommended.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Max: 5 mg daily.
Contraindication
Uncontrolled narrow-angle glaucoma, urinary retention, gastric retention.
Mode of Action
Solifenacin is a selective M3 antimuscarinic that inhibits muscarinic receptors resulting in decreased urinary bladder contraction, increased residual urine volume and decreased detrusor muscle pressure.
Precaution
Increased risk of urinary retention in patients with bladder outflow obstruction. Caution in patients with decreased GI motility, GI obstructive diseases, controlled narrow-angle glaucoma, liver or kidney impairment, patients with known history of QT prolongation or other risk factors for QT prolongation. May cause drowsiness and/or blurred vision. Monitor serum creatinine clearance and liver function. Maintain adequate hydration. Increased susceptibility to heat prostration due to reduced ability to sweat. Pregnancy, lactation.
Side Effect
Constipation, dyspepsia, nausea, upper abdominal pain, xerostomia, hypertension, oedema, headache, depression, fatigue, urinary tract infection, blurred vision, cough, influenza.
Interaction
May interfere with the prokinetic effects of cisapride and metoclopramide.
Potentially Fatal: May reduce the stimulatory effect of secretin. Concurrent use with biperiden, orphenadrine, procyclidine or trihexyphenidyl may cause anticholinergic effects such as confusion and loss of bladder control; a washout period of 1 wk between using these drugs is recommended. May increase the ulcerogenic effect of potassium chloride.
Strong CYP3A4 inhibitors (e.g. ketoconazole, fluconazole, itraconazole, erythromycin, telithromycin, clarithromycin, ritonavir, indinavir, nelfinavir, nefazodone, aprepitant, verapamil) may reduce the metabolism of solifenacin, thus increasing its plasma levels.
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