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Itranox-100
Silva Pharmaceuticals Ltd.
Generic: Itraconazole
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Itranox-100. Please consult your doctor.
CONSULT YOUR DOCTOR
Itranox-100 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Itranox-100 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Itranox-100 may cause side effects which could affect your ability to drive.
Itranox-100 can sometimes cause dizziness, blurred/double vision or hearing loss. This may affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Itranox-100 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Itranox-100 in patients with liver disease. Please consult your doctor.
Inform your doctor if you develop signs of jaundice like yellowing of eyes and skin, itching, and clay colored stools while taking this medicine.
Medicine Overview of Itranox-100mg capsule
Introduction
Itranox-100 belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat infections of the mouth, throat, vagina and other parts of the body including fingernails and toenails. It kills fungi by destroying the fungal cell membrane. Itranox-100 should be taken in the dose and duration as prescribed by your doctor. It should be swallowed whole and can be taken with food. The dosage and length of treatment will depend on the condition you are being treated for. Sometimes this will be in cycles of use and non-use. To get...
... Show moreUses of Itranox-100
- Fungal infections
Side effects of Itranox-100
Common
- Nausea
- Common cold
- Cough
- Blurred vision
- Menstrual disorder
How to use Itranox-100
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Itranox-100 is to be taken with food.
How Itranox-100 works
Itranox-100 is an antifungal medication. It kills fungi by destroying the fungal cell membrane. This treats your skin infection.
What if you forget to take Itranox-100?
If you miss a dose of Itranox-100, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Itranox-100 helps treat fungal infections of mouth, skin, vagina or any other parts of the body.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Take it with food, preferably at the same time everyday.
- Use a reliable method of contraception to prevent pregnancy while taking this medicine.
- Do not take indigestion remedies (antacids) within two hours of taking Itranox-100.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Inform your doctor if you develop allergic reactions, nerve pain, or hearing loss.
Brief Description
Indication
Candidiasis, Fungal infections, Tinea pedis, Tinea cruris, Tinea corporis, Pityriasis versicolor
Administration
Should be taken with food. Take immediately after a full meal.
Adult Dose
Oral Adult: PO: Oropharyngeal candidiasis As cap: 100 mg/day for 15 days. Vulvovaginal candidiasis As cap: 200 mg twice daily for 1 day. Pityriasis versicolor As cap: 200 mg/day for 7 days. Tinea corporis; Tinea cruris As cap: 100 mg/day for 15 days. Fungal nail infections As cap: 200 mg/day for 3 mth. Systemic fungal infections As cap: 100-200 mg once daily, up to 200 mg twice daily for invasive or disseminated infections. Prophylaxis of infections in neutropenic or AIDS patients As cap: 200 mg/day, up to 200 mg twice daily if needed. Tinea pedis; Tinea manuum As cap: 100...
... Show moreChild Dose
Child: PO 10 mg/kg/day, max 200 mg/day q12h
5 mg/kg/day for chronic mucocutaneous Candida q24h
<3 years: Safety and efficacy not established
Contraindication
Hypersensitivity to azole antifungals; pregnancy and lactation; hepatic disease. IV: CrCl: <30 ml/min.
Mode of Action
Itraconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity. This inhibits cell membrane function of susceptible fungi including Microsporum spp., Trichophyton spp., Candida spp., Aspergillus spp., Epidermophyton spp., Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, sporothrix schenckii, Malassezia furfur, Coccidioides immitis and Paracoccidiodes brasiliensis. It also has antiprotozoal activity against Leishmania spp.
Precaution
Renal insufficiency; CHF, history of CHF, COPD; monitor liver function.
Lactation: Drug enters breast milk; weigh risk against benefit
Side Effect
>10%
Nausea (11%)
1-10%
Rash (9%),Vomiting (5%),Edema (4%),Headache (4%),Abnormal liver function test results (3%),Diarrhea (3%),Fever (3%),Hypertension (3%),Pruritus (3%),Fatigue (2-3%),Abdominal pain (2%),Dizziness (2%),Hypertriglyceridemia (2%),Hypokalemia (2%),Albuminuria (1%),Anorexia (1%),Decreased libido (1%),Hepatitis (1%),Malaise (1%)
Potentially Fatal: Liver failure; heart failure; pulmonary oedema; CV disease.
Interaction
May increase the plasma concentrations of oral anticoagulants, digoxin, cilostazol, alprazolam, midazolam (IV), repaglinide, corticosteroids (e.g. budesonide, dexamethasone, fluticasone, methylprednisolone). May increase plasma concentration w/ HIV protease inhibitors (e.g. ritonavir, indinavir, saquinavir), erythromycin, clarithromycin. May reduce plasma concentration w/ isoniazid, carbamazepine, nevirapine, phenytoin, Phenobarbital, rifampicin, rifabutin. May reduce absorption w/ PPIs, antacids, antimuscarinics, histamine H2 receptor antagonists. Concomitant use w/ dihydropyridines may cause oedema. May increase negative inotropic effects of verapamil. May increase risk of potentially fatal resp depression w/ fentanyl. Potentially Fatal: May increase risk of QT prolongation or torsades de pointes w/ astemizole, bepridil, cisapride, dofetilide, levacetylmethadol (levomethadyl),...
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