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Doloran Plus
Nevian Lifescience PLC
Generic: Paracetamol + Tramadol Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Doloran Plus.
CONSULT YOUR DOCTOR
Doloran Plus may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Doloran Plus is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.
UNSAFE
Doloran Plus may cause side effects which could affect your ability to drive.
Doloran Plus may cause side effects such as drowsiness and blurred vision. If this happens, do not drive.
CAUTION
Doloran Plus should be used with caution in patients with kidney disease. Dose adjustment of Doloran Plus may be needed. Please consult your doctor.
CAUTION
Doloran Plus should be used with caution in patients with liver disease. Dose adjustment of Doloran Plus may be needed. Please consult your doctor.
Medicine Overview of Doloran Plus 325mg+37.5mg Tablet
Introduction
Doloran Plus is a pain relieving medicine. It is used in various conditions such as muscle ache, back pain, joint pain, menstrual cramps, and toothache. Doloran Plus can be taken with or without food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is alright to stop using it. Using this medicine may cause few common side effects such as nausea, vomiting, constipation, weakness, and dryness in mouth. If you experience any such...
... Show moreUses of Doloran Plus
- Pain relief
Side effects of Doloran Plus
Common
- Nausea
- Vomiting
- Constipation
- Weakness
- Dizziness
- Dryness in mouth
- Sleepiness
How to use Doloran Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Doloran Plus may be taken with or without food, but it is better to take it at a fixed time.
How Doloran Plus works
Doloran Plus is a combination of two medicines: Paracetamol/Acetaminophen and Tramadol. Paracetamol/Acetaminophen is an analgesic (pain reliever) which works by blocking the release of certain chemical messengers that cause pain. Tramadol is an opioid analgesic (pain reliever) which works by blocking the transmission of pain signals to the brain to lower pain perception.
Quick Tips
- Use only for severe acute pain for not more than 5 days.
- Prolonged use may result in physical and psychological dependence even at recommended dosages.
- It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- It is better to take with food to avoid an upset stomach.
- Your doctor may adjust your dose if you have liver or kidney disease.
- In case of overdose, tell your doctor immediately.
Brief Description
Indication
Moderate to severe pain
Administration
May with or without food.
Adult Dose
Oral
Moderate to severe pain
Adult: 1-2 tab 6 hrly.
Max: 8 tab/day. Max duration: 5 days.
Hepatic impairment: Moderate: Increase dosing interval. Severe: Contraindicated.
Child Dose
Not recommended in child under 18 years of age.
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30 Increase dosing interva to 12 hr.ly
<10 Not recommended.
Contraindication
Hypersensitivity to tramadol, paracetamol or opioids. Situations where opioid use may be contra-indicated (e.g. acute intoxication with alcohol, hypnotic drugs, centrally-acting analgesics, opioids or psychotropic drugs). Severe hepatic impairment, uncontrolled epilepsy. Concurrent use or within 2 wk of discontinuation from MAOIs.
Mode of Action
Tramadol is a centrally acting opioid analgesic which binds to mu-opioid receptors and weakly inhibits the reuptake of norepinephrine and serotonin. Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity. Together, tramadol and paracetamol has faster onset of action compared to tramadol alone and longer duration of action compared to paracetamol alone.
Precaution
Patient w/ epilepsy controlled by treatment, risk of seizure, cranial trauma, biliary tract disorder, altered state of consciousness for unknown reasons, problems affecting the resp centre or resp function, increased intracranial pressure, suicidal tendency or patients in a state of shock. Not a suitable substitute in opioid-dependent patients. May cause withdrawal symptoms, dependence and abuse. Severe renal impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor pain relief, resp rate, BP, and pulse rate; signs of tolerance, abuse, or suicidal ideation.
Side Effect
Postural hypotension, resp depression, hepatotoxicity, Stevens-Johnson syndrome, toxic epidermal necrolysis, bradycardia, collapse, allergic reactions w/ resp symptoms (e.g. dyspnoea, bronchospasm, wheezing, angioneurotic oedema), changes in appetite, motor weakness, changes in mood, activity, cognitive and sensorial capacity; exacerbation of asthma, withdrawal symptoms (e.g. agitation, anxiety), skin rash, blood dyscrasias, hypoprothrombinemia.
Potentially Fatal: Severe anaphylactic reactions.
Interaction
Increased risk of seizures and serotonin syndrome w/ SSRIs, SNRIs, TCAs, and 5-HT agonists (e.g. sumatriptan). Increased CNS depression w/ barbiturates, benzodiazepines, other anxiolytics, hypnotics, sedative antidepressants, sedative antihistamines, neuroleptics, centrally-acting antihypertensive drugs, thalidomide and baclofen. Decreased analgesic efficacy w/ ondansetron. Increased INR w/ warfarin.
Potentially Fatal: Increased risk of seizure and serotonin sydrome w/ MAOIs.
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