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Drucil
Healthcare Pharmaceuticals Ltd.
Generic: 5-Fluorouracil (5-FU)
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Drucil. Please consult your doctor.
CONSULT YOUR DOCTOR
Drucil is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Drucil is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Drucil may cause side effects which could affect your ability to drive.
Drucil can cause side effects such as nausea and can also produce adverse events on your nervous system which cause visual changes.This may affect your ability to drive.
SAFE IF PRESCRIBED
Drucil is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Drucil may not be needed in these patients. Please consult your doctor.
CAUTION
Drucil should be used with caution in patients with liver disease. Dose adjustment of Drucil may be needed. Please consult your doctor.
Medicine Overview of Drucil 250mg/10ml Injection
Introduction
Drucil is used in the treatment of cancers of stomach, colon, rectum, breast, and lungs. It may be used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy. Drucil is given as injection under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way...
... Show moreUses of Drucil
- Cancer
Side effects of Drucil
Common
- Increased risk of infection
- Mouth ulcer
- Vomiting
- Weakness
- Nausea
- Loss of appetite
- Hair loss
- Blisters on fingers/feet
- Decreased blood cells (red cells, white cells, and platelets)
- Diarrhea
How to use Drucil
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Drucil works
Drucil is an anticancer medication. It works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Quick Tips
- Drucil helps treat cancers of stomach, colon, rectum, breast, and lungs.
- It is given as an injection into a vein, or as a drip (infusion) into a vein or artery.
- The dose and the number of treatment cycles needed will depend on the type and stage of cancer that is being treated.
- It may cause dizziness and visual changes. Do not drive or do anything requiring concentration until you know how it affects you.
- Your doctor may regularly monitor your blood cells and liver function during treatment with this medicine.
Brief Description
Indication
Palliation of malignant neoplasms, Superficial basal cell carcinoma, Oesophageal carcinoma, Carcinoma of Colon, Carcinoma of Breast, Carcinoma of Ovary, Carcinoma of Liver, Carcinoma of Pancreas, Carcinoma of Rectum, Carcinoma of Stomach
Administration
IV Preparation IV Push: dose/syringe (concentration: 50 mg/mL); max syringe size for IVP is 30 mL syringe and syringe should be <75% full Continuous IV Infusion/IVPB: dose/50-1000 mL D5W or NS; syringe and solution are stable for 72 hr at 4 to 25°C IV Administration Direct IV push injection (50 mg/mL solution needs no further dilution) or by IV infusion Toxicity may be reduced by giving the drug as a constant infusion Bolus doses may be administered by slow IVP or IVPB Warm to body temperature before using Continuous IV infusion may be administered in D5W or NS Solution should...
... Show moreAdult Dose
Adult: IV Palliation of malignant neoplasms 12 mg/kg/day (max: 0.8-1g/day) for 3-4 days, if no toxicity occurs, may be followed after 1 day w/ 6 mg/kg on alternate days for another 3-4 doses. May repeat course 4-6 wk later or maintenance doses of 5-15 mg/kg (max: 1 g) may be given wkly. Cancers of Colon, Breast, Ovary, Liver, Pancreas, Rectum, Stomach Various protocols exist 500 mg/sq.meter IV on Days 1-5, OR 450-600 mg/sq.meter IV weekly, OR 200-400 mg/sq.meter IV continuous infusion qD Not to exceed 800 mg/day As an infusion: 15 mg/kg/day (max: 1 g/day), continue until toxicity occurs or...
... Show moreChild Dose
Child: Safety & efficacy not established.
Renal Dose
Renal impairment: Dose reduction may be required.
Contraindication
Topical application on mucous membranes, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutritional status, potentially serious infections. Pregnancy and lactation.
Mode of Action
Fluorouracil interferes with DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid. It also interferes with RNA synthesis. This results in an unbalanced growth of the cells. Fluorouracil exerts greater effect on rapidly growing cells as they take up the drug at a faster rate.
Precaution
Regular monitoring of blood counts. History of heart disease, hepatic or renal insufficiency, weak or malnourished patients, patients who with history of high-dose pelvic radiation or use of alkylating agents. Patients with widespread metastases to the bone marrow.
Lactation: excretion in milk unknown; do not nurse.
Side Effect
1-10%
Loss of appetite,Headache,Nausea,Vomiting,Diarrhea,Mucositis,Myelosuppression,Alopecia,Photosensitivity,Hand-foot syndrome,Maculopapular eruption (pruritic)
Frequency Not Defined
Angina,Coronary arteriosclerosis,Thrombophlebitis,Darkening of veins,Gastrointestinal ulcer,Increased alkaline phosphatase,Increased LFTs,Hyperbilirubinemia,Hypercholesterolemia (increased LDH),Anaphylaxis,Nystagmus,Ophthalmic findings
Potentially Fatal: Central neurotoxicity, myocardial ischaemia.
Pregnancy Category Note
Pregnancy Category: D
Risk Summary
There are no adequate and well-controlled studies with fluorouracil in pregnant women. Based on its mechanism of action, fluorouracil can cause fetal harm when administered to a pregnant woman.
Lactation: excretion in milk unknown; do not nurse
Interaction
May increase warfarin effects. May reduce response to vaccines; possibility of generalized infection with live vaccines. Action may be modified by allopurinol. Leucovorin calcium may enhance the toxicity of fluorouracil.
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