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Duralast
Sun Pharmaceutical (Bangladesh) Ltd.
Generic: Dapoxetine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Duralast.
CONSULT YOUR DOCTOR
Information regarding the use of Duralast during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Duralast during breastfeeding is not available. Please consult your doctor.
UNSAFE
Duralast may cause side effects which could affect your ability to drive.
You may feel sleepy, dizzy, faint, have difficulty concentrating and blurred vision while taking this medicine. This may affect your driving ability.
CAUTION
Duralast should be used with caution in patients with kidney disease. Dose adjustment of Duralast may be needed. Please consult your doctor.
Use of Duralast is not advised in patients with severe kidney disease.
CAUTION
Duralast should be used with caution in patients with liver disease. Dose adjustment of Duralast may be needed. Please consult your doctor.
Use of Duralast is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Duralast 60mg Tablet
Introduction
Duralast is a medicine used to treat premature ejaculation in adult men. This medicine increases the time it takes to ejaculate and improve control over ejaculation. This helps to relieve the anxiety or frustration about fast ejaculation. Duralast belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRI). It may be taken with or without food. This medicine should only be taken if you have been diagnosed with premature ejaculation by a doctor. It is usually advised to be taken 1 to 3 hours before anticipated sexual activity. Do not take it more than once in a...
... Show moreUses of Duralast
- Premature ejaculation
Side effects of Duralast
Common
- Drowsiness
- Nausea
- Tremor
- Vomiting
- Dizziness
- Erectile dysfunction
- Fatigue
- Headache
- Increased sweating
- Indigestion
- Restlessness
How to use Duralast
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duralast may be taken with or without food, but it is better to take it at a fixed time.
How Duralast works
Duralast is a selective serotonin reuptake inhibitor (SSRI) which increases the level of serotonin in the nervous system to increase the time taken to ejaculate and improve control over ejaculation.
What if you forget to take Duralast?
If you miss a dose of Duralast, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Duralast should only be taken 1 to 3 hours before sexual activity is anticipated.
- Do not take this medicine more than once 24 hours or every day.
- Do not drive or do anything requiring concentration until you know how Duralast affects you.
- It should be used with caution in patients with history of seizures, depression and other psychiatric disorders.
- Duralast may cause a sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
- Talk to your doctor before taking this medicine if you are suffering from erectile dysfunction.
Brief Description
Indication
Premature ejaculation
Administration
May be taken with or without food. Swallow tab whole & take w/ a full glass of water.
Adult Dose
Oral
Premature Ejaculation
Adult: 18-64 yr Initially, 30 mg approx 1-3 hr before sexual activity, subsequent doses adjusted according to response. Max: 60 mg. Dose should not be taken more than once in 24 hr. Review treatment after 4 wk (6 doses) and at least 6 mthly thereafter.
Hepatic Impairment: Moderate to severe: Contraindicated.
Renal Dose
Patients with Renal Impairment: No dose adjustment is required but caution is advised in patients with mild or moderate renal impairment. Dapoxetine is not recommended for use in the patients with severe renal impairment.
Contraindication
Known hypersensitivity to dapoxetine HCl or to any of the excipients. Patients with significant pathological cardiac conditions [eg, heart failure (NYHA class II-IV), conduction abnormalities (2nd- or 3rd-degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease or significant valvular disease]. Concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days of discontinuing treatment with a MAOI. Similarly, a MAOI should not be administered within 7 days after Dapoxetine has been discontinued. Concomitant treatment with thioridazine, or within 14 days of discontinuing treatment with thioridazine. Similarly, thioridazine should not be administered within...
... Show moreMode of Action
Dapoxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors.
Precaution
General: Dapoxetine is only indicated in men with PE. Safety has not been established and there are no data on the ejaculation-delaying effects in men without PE. Use with Recreational Drugs: Patients should be advised not to use Dapoxetine in combination with recreational drugs. Recreational drugs with serotonergic activity eg, ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions if combined with Dapoxetine. These reactions include, but are not limited to, arrhythmia, hyperthermia and serotonin syndrome. Use of Dapoxetine with recreational drugs with sedative properties eg, narcotics and benzodiazepines may further increase somnolence and dizziness....
... Show moreSide Effect
Syncope characterized as loss of consciousness has been reported.The majority of cases occurred during the first 3 hrs after dosing, after the 1st dose or associated with study-related procedures in the clinic setting (eg, blood draw and orthostatic maneuvers and blood pressure measurements). Prodromal symptoms often preceded the syncope.
Orthostatic hypotension has been reported in clinical trials.
The most common adverse drug reactions (5%) reported during clinical trials were headache, dizziness, nausea, diarrhea, insomnia and fatigue. The most common events leading to discontinuation were nausea and dizziness.
Interaction
Potential serious reactions w/ MAOIs. Inhibits metabolism of thioridazine. Risk of serotonergic-associated effects w/ serotonergic medicinal/herbal products (including L-tryptophan, triptans, tramadol, linezolid, SSRIs, SNRIs, lithium & St. John's wort prep). CNS-active medicinal products. Possible reduction of clearance w/ CYP2D6, CYP3A4 & flavin monooxygenase 1 inhibitors. Increased exposure w/ potent (eg ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir & atazanavir) & moderate (eg erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem) CYP3A4 inhibitors; potent CYP2D6 inhibitors. Possible reduced orthostatic tolerance w/ PDE-5 inhibitors & ?-adrenergic receptor antagonists. Increases plasma conc of desipramine & other drugs metabolized by CYP2D6. Decreases AUCinf of...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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