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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Barri 2 does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Barri 2 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Barri 2 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
SAFE
Barri 2 does not usually affect your ability to drive.
UNSAFE
Barri 2 is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
SAFE IF PRESCRIBED
Barri 2 is safe to use in patients with liver disease. No dose adjustment of Barri 2 is recommended.
Barri 2 may not be recommended in patients with severe liver disease due to lack of information and research. Therefore, it is important to consult the doctor.
Medicine Overview of Barri 2mg Tablet
Introduction
Barri 2 is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis. It helps decrease pain, tenderness and swelling in the joints by reducing inflammation. It also helps slow the progression of bone and joint damage. Barri 2 may be prescribed alone or in combination with another drug. The tablets can be taken with or without food, but it is best to take them at the same time each day. Your dose will depend on your condition and what other medicines you are taking. You should use it as your doctor tells you to. Do not stop...
... Show moreUses of Barri 2
- Rheumatoid arthritis
Side effects of Barri 2
Common
- Nausea
- Upper respiratory tract infection
How to use Barri 2
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Barri 2 may be taken with or without food, but it is better to take it at a fixed time.
How Barri 2 works
Barri 2 is Janus kinase inhibitor. It works by blocking the action of the enzyme, Janus kinase. This decreases inflammation and joint damage in rheumatoid arthritis.
Quick Tips
- Barri 2 is used alone or in combination with methotrexate for the treatment of rheumatoid arthritis that did not improve with other anti-rheumatic drugs.
- It may take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed.
- Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts or cholesterol level.
- Barri 2 can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
- Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication.
- Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Rheumatoid Arthritis
Adult Dose
Rheumatoid Arthritis
Indicated for adults with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies
May be used as monotherapy or in combination with methotrexate or other nonbiologic disease-modifying antirheumatic drugs (DMARDs)
2 mg PO qDay
Mode of Action
Janus kinases (JAKs) pathways inhibitor; JAK consists of a group of intracellular tyrosine kinases that transmit signals from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoieses and immune cell function
Within the signaling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which modulate intracellular activity including gene expression; baricitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs
Precaution
Serious and sometimes fatal infections may develop owing to bacterial, mycobacterial, invasive fungal, viral, or other opportunistic pathogens reported; may cause reactivation of latent TB or viral infections (see Black Box Warnings and Dosing Considerations) Consider risks and benefits before initiating in patients with chronic or recurrent infection, history of serious or opportunistic infection, underlying conditions predisposing them to infection, or patients who have been exposed to tuberculosis or have resided or traveled in areas of endemic tuberculosis or mycoses (see Black Box Warnings) Consider TB therapy for patients with a negative test for latent TB but who have risk...
... Show moreSide Effect
>10%
Upper respiratory tract infections (16.3%)
1-10%
Nausea (2.7%)
Increased LFTs (1-2%)
Platelet elevations (1-2%)
Herpes zoster infection (1%)
<1%
Acne (<1%)
Herpes simplex infection (0.8%)
Neutropenia (0.3%)
Pregnancy Category Note
Pregnancy Data in pregnant women are insufficient to inform a drug-associated risk for major birth defects or miscarriage Animal studies In animal embryo-fetal development studies, oral baricitinib administration to pregnant rats and rabbits at exposures equal to and greater than ~20 and 84 times the maximum recommended human dose (MRHD), respectively, resulted in reduced fetal body weights, increased embryo lethality (rabbits only), and dose-related increases in skeletal malformations Lactation Unknown if distributed in human breast milk Baricitinib is present in the milk of lactating rats Owing to species-specific differences in lactation physiology, the clinical relevance of these data are not...
... Show moreInteraction
Avoid use of live vaccines; update immunizations in agreement with current immunization guidelines before initiating
Coadministration with strong OAT3 inhibitors may increase baricitinib systemic exposure
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