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Exemis 25
Eskayef Pharmaceuticals Ltd.
Generic: Exemestane
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Exemis 25. Please consult your doctor.
UNSAFE
Exemis 25 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Exemis 25 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Exemis 25 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Exemis 25 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Exemis 25 may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Exemis 25 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Exemis 25 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Exemis 25mg Tablet
Introduction
Exemis 25 is an aromatase inhibitor. It is used in the treatment of breast cancer in women who have gone through menopause. It works by adjusting the level of estrogen and helps in slowing down the growth of cancer cells. Exemis 25 is also used in combination with medication in early cancer to prevent the risk of coming back. It should be taken with food, but take it at the same time every day to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are...
... Show moreUses of Exemis 25
- Breast cancer
Side effects of Exemis 25
Common
- Insomnia (difficulty in sleeping)
- Headache
- Nausea
- Increased sweating
- Musculoskeletal (bone, muscle or joint) pain
- Fatigue
How to use Exemis 25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Exemis 25 is to be taken with food.
How Exemis 25 works
Exemis 25 is an aromatase inhibitor. It works by lowering the amount of estrogen (natural female hormone) produced in the body. This can lower or stop the growth of some breast cancer cells that need estrogen to grow.
What if you forget to take Exemis 25?
If you miss a dose of Exemis 25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Exemis 25 is used for the treatment of hormone dependent breast cancer in postmenopausal women.
- Take it at the same time everyday, preferably after food.
- It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Your doctor may regularly check your Vitamin D level and bone mineral density and suggest supplements, if needed.
- Do not take Exemis 25 if you are pregnant or breastfeeding.
Brief Description
Indication
Breast cancer in postmenopausal women
Administration
Should be taken with food. Take after a meal.
Adult Dose
Oral
Advanced or locally advanced breast cancer
Adult: In women who are no longer responsive to anti-oestrogen therapy: 25 mg once daily.
Contraindication
Hypersensitivity. Premenopausal women. Pregnancy and lactation.
Mode of Action
Exemestane is an irreversible selective aromatase inhibitor which acts as a false substrate for the aromatase enzyme, forming an intermediate that binds irreversibly to the active site causing its inactivation. It also lowers circulating oestrogens in estrogen-dependent breast carcinoma.
Precaution
Hepatic and renal impairment. Monitor bone mineral density at regular intervals especially in patients at risk of osteoporosis.
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Side Effect
>10%
Fatigue (22%),Nausea (18%),Hot flashes (13%),Depression (13%),Pain (13%),Insomnia (11%)
1-10%
Anxiety (10%),Dyspnea (10%),Dizziness (8%),Headache (8%),Edema (7%),Vomiting (7%),Flu-like syndrome (6%),Abdominal pain (6%),Anorexia (6%),Cough (6%),Hypertension (5%),Constipation (5%),Diarrhea (4%)
<1%
Cardiac failure,Uterine polyps,Endometrial hyperplasia,Gastric ulcer
Frequency not defined
Hepatitis,Visual disturbances
Pregnancy Category Note
Pregnancy Category: X
Lactation: Excretion in milk unknown; because of potential for serious adverse reactions in breast-fed infants, advise women not to breastfeed during treatment and for 1 month after final dose
Interaction
May result in reduced plasma levels of exemestane when used with CYP3A4 enzyme inducers. Oestrogen-containing drugs; St. John's wort, black cohosh, dong quai.
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