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Safety Advices
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UNSAFE
5/40 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
5/40 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
5/40 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
5/40 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
5/40 should be used with caution in patients with severe kidney disease. Dose adjustment of 5/40 may be needed. Please consult your doctor.
Regular monitoring of blood pressure is advisable for dose adjustment.
CAUTION
5/40 should be used with caution in patients with severe liver disease. Dose adjustment of 5/40 may be needed. Please consult your doctor.
No dose adjustment is recommended in patients with mild liver disease.
Medicine Overview of 5/40
Introduction
5/40 is a medicine used to treat high blood pressure and heart failure. Lowering blood pressure helps to prevent future heart attack and stroke. This medicine is also effective in preserving kidney function in patients with diabetes. 5/40 can be prescribed either alone or in combination with other medicines. It may be taken with or without food during the day or at night. However, try to take it at the same time each day to get the maximum benefit. It is important to continue taking it regularly even if you feel well or if your blood pressure is controlled. Most...
... Show moreUses of 5/40
- Hypertension (high blood pressure)
- Heart failure
- Prevention of heart attack and stroke
Side effects of 5/40
Common
- Cough
- Diarrhea
- Dizziness
- Flu-like symptoms
- Headache
- Indigestion
- Nausea
- Runny nose
- Sore throat
- Stomach pain
How to use 5/40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. 5/40 may be taken with or without food, but it is better to take it at a fixed time.
How 5/40 works
5/40 is an angiotensin receptor blocker (ARB). It relaxes the blood vessel by blocking the action of a chemical that usually makes blood vessels tighter. This lowers the blood pressure, allowing the blood to flow more smoothly to different organs and the heart to pump more efficiently.
What if you forget to take 5/40?
If you miss a dose of 5/40, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it at the same time every day to help you remember to take it.
- It can make you feel dizzy for the first few days. Rise slowly if you have been sitting or lying down for a long time.
- Your doctor may get regular tests done to monitor the level of urea, creatinine, and potassium in your blood.
- Avoid taking anti-inflammatory medicines such as ibuprofen along with this medicine without consulting your doctor.
- It may increase the level of potassium in the blood. Avoid taking potassium supplements and potassium-rich foods such as banana fruit juice, coconut water, and broccoli.
- Do not take 5/40 if you are pregnant or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor.
Brief Description
Indication
Hypertension, Diabetic nephropathy,
Adult Dose
Oral
Hypertension
Adult: Initial: 10-20 mg once daily may then be increased up to max 40 mg once daily if needed.
Elderly: No dosage adjustment needed.
Hepatic impairment: Moderate: Initial: 10 mg once daily may increase up to max 20 mg once daily.
Child Dose
Oral
Hypertension
Child: 6-16 yr 35 kg: 20 mg once daily. Doses may be doubled once if necessary after 2 wk. dosage range: 20-40 mg/day
Renal Dose
Renal impairment: Mild to moderate (CrCl: 20-60 mL/min): Max: 20 mg once daily.
Contraindication
Pregnancy (2nd and 3rd trimesters); biliary obstruction.
Mode of Action
Olmesartan is a selective and competitive angiotensin II Type 1 (AT1) receptor antagonist that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. As a result, olmesartan relaxes blood vessels, hence lowering BP and increases blood supply and oxygen to the heart.
Precaution
Drugs that act on renin-angiotensin system can cause fetal injury and death when used in 2nd and 3rd trimesters of pregnancy. Olmesartan medoxomil should be discontinued as soon as possible once pregnancy is detected. Symptomatic hypotension may occur in patients who are volume- and/or salt-depleted. May be associated with oliguria, progressive azotaemia, and acute renal failure (rare). Patients with bilateral or unilateral renal artery stenosis may have increased risk of severe hypotension and renal insufficiency. Caution in renal impairment; monitor serum creatinine and potassium levels periodically. Avoid use in severe renal impairment (CrCl< 20 mL/min) and severe hepatic impairment. Caution...
... Show moreSide Effect
1-10%
Dizziness,Headache,Fatigue,Diarrhea,Hyperglycemia,Hypertriglyceridemia,Back pain,Bronchitis,Inflicted injury,Flulike symptoms,Pharyngitis,Rhinitis,Sinusitis,Upper respiratory tract infection (URTI)
Frequency Not Defined (selected)
Anaphylactic reaction,Angioedema,Facial edema,Rhabdomyolysis,Hyperkalemia,Tachycardia,Hypercholesterolemia,Gastroenteritis,Hyperlipidemia
Potentially Fatal: Acute renal failure.
Pregnancy Category Note
Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D
Interaction
Increased risk of hyperkalaemia w/ ACE inhibitors, K-sparing diuretics, K salts or K supplements and drugs that may increase serum K (e.g. ciclosporin, eplerenone). May potentiate BP lowering effects w/ other antihypertensives. May decrease glomerular filtration w/ NSAIDs which can cause acute renal failure. May increase serum concentrations and toxicity of lithium.
