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Avas EZ 20/10
Opsonin Pharma Limited
Generic: Atorvastatin + Ezetimibe
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Avas EZ 20/10.
UNSAFE
Avas EZ 20/10 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Avas EZ 20/10 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Avas EZ 20/10 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Avas EZ 20/10 is safe to use in patients with kidney disease. No dose adjustment of Avas EZ 20/10 is recommended.
CAUTION
Avas EZ 20/10 should be used with caution in patients with liver disease. Dose adjustment of Avas EZ 20/10 may be needed. Please consult your doctor.
Use of Avas EZ 20/10 is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Avas EZ 20/10mg+10mg tablet
Introduction
Avas EZ 20/10 is a medicine used to treat high cholesterol. It is a combination of two medicines that reduces "bad" cholesterol (LDL) and triglycerides (fats) levels. Avas EZ 20/10 can be taken with or without food. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you remember to take it. The dose and duration of treatment will depend on what you are being treated for. Do not stop taking it until you have finished the complete course, even when you feel...
... Show moreUses of Avas EZ 20/10
- High cholesterol
Side effects of Avas EZ 20/10
Common
- Nausea
- Constipation
- Stomach pain
- Headache
- Muscle pain
- Increased liver enzymes
- Increased glucose level in blood
How to use Avas EZ 20/10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avas EZ 20/10 may be taken with or without food, but it is better to take it at a fixed time.
How Avas EZ 20/10 works
Avas EZ 20/10 is a combination of two medicines: Atorvastatin and ezetimibe. Atorvastatin is a lipid-lowering medicine which prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL) levels. Ezetimibe is a cholesterol absorption inhibitor which prevents absorption of cholesterol from the intestines. Together, they provide better reduction of cholesterol in your body.
Quick Tips
- You have been prescribed Tonact EZ Tablet for the treatment of high cholesterol.
- Take it in addition to regular exercise and low-fat diet to lower levels of fat in the blood.
- It can be taken with or without food.
- Notify your doctor if you experience muscle symptoms (pain or weakness), particularly if accompanied with fever.
- Notify your doctor if you experience stomach pain, loss of hunger, a sick feeling or dark urine.
Brief Description
Indication
Hypercholesterolaemia, Primary Hyperlipidemia
Administration
May be taken with or without food.
Adult Dose
Oral
Hypercholesterolaemia
Adult: Per tablet contains atorvastatin 10 mg and ezetimibe 10 mg: Usual starting: 1 tablet once daily.
Child Dose
Safety and efficacy not established
Contraindication
Hypersensitivity; active liver disease or unexplained persistent elevated liver function tests. Pregnancy and lactation.
Mode of Action
Atorvastatin competitively inhibits HMG-CoA reductase, the enzyme that catalyses the conversion of HMG-CoA to mevalonate which is an early rate-limiting step in cholesterol biosynthesis. Ezetimibe inhibits the absorption of cholesterol from the intestine, thus decreasing the delivery of intestinal cholesterol to the liver.
Precaution
Hepatic impairment; patients consuming substantial quantities of alcohol with a history of liver disease. Not recommended for use in children <10 yr.
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.
Side Effect
1-10%
Increased ALT (5%),Increased AST (4%),Musculoskeletal pain (4%),Abdominal pain (3%),Nausea (3%),Arthralgias (3%),Muscle weakness (2%),Dizziness (2%),Hyperkalemia (2%),Hot flushes (2%),Coughing (2%),Bronchitis (2%),Sinusitis (2%)
Pregnancy Category Note
Pregnancy Category: X
Lactation: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breast feed. Contraindicated in breastfeeding women.
Interaction
Atorvastatin: Increases digoxin levels; increases anticoagulant effect of warfarin. Avoid the combination of HMG-CoA reductase inhibitors and fibrates. Ezetimibe: Cholestyramine decreases AUC of ezetimibe by approx 55%; ciclosporin may increase ezetimibe levels.
Potentially Fatal: Antacids decrease atorvastatin levels; colestipol decreases atorvastatin plasma levels; propranolol decreases antihyperlipidaemic activity of atorvastatin.
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