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Incepta Pharmaceuticals Ltd.
Generic: Emtricitabine + Tenofovir disoproxil
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Emtifovir. Please consult your doctor.
SAFE IF PRESCRIBED
Emtifovir is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Emtifovir is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Emtifovir may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Emtifovir should be used with caution in patients with kidney disease. Dose adjustment of Emtifovir may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Emtifovir is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Emtifovir may not be needed in these patients. Please consult your doctor.
Medicine Overview of Emtifovir 200mg+300mg Tablet
Introduction
Emtifovir belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better. Emtifovir is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It may also be used to prevent HIV infection in some people at high risk. It may be prescribed alone or in combination with other HIV medicines....
... Show moreUses of Emtifovir
- HIV infection
Side effects of Emtifovir
Common
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Nausea
- Rash
How to use Emtifovir
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Emtifovir is to be taken with food.
How Emtifovir works
Emtifovir is a combination of two anti-HIV medicines: Emtricitabine and Tenofovir disoproxil fumarate. They prevent HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.
Quick Tips
- Tafero EM Tablet is a combination of two medicines which slows down or stops the progression of HIV infections.
- It may also be used for preventing HIV and should be started within 72 hours of exposure to HIV.
- Take it with food, as this increases the absorption of the medicine into the body.
- Tafero EM Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
- Always practice safe sex while taking Tafero EM Tablet. Do not share needles or personal items that can have blood or body fluids on them.
- It may cause weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Brief Description
Indication
HIV-1 infection, Pre-exposure Prophylaxis HIV-1 infection
Administration
May be taken with or without food. Take consistently either always w/ or always w/o food.
Adult Dose
Oral
HIV-1 infection, Pre-exposure Prophylaxis in combination with other antiretroviral agents
Adult: 1 tablet once daily.
Hepatic impairment
Dose adjustment not necessary in moderate-to-severe hepatic impairment
Renal Dose
Renal impairment: Patient on haemodialysis: Not recommended.
CrCl (ml/min)
30-49 1 tablet every 48 hr.
<30 Not recommended.
Contraindication
Lactation. Not to be used for treatment of chronic hepatitis B virus (HBV) infection.
Mode of Action
Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is rapidly converted to tenofovir, an acyclic nucleoside phosphonate (nucleotide) analogue of adenosine 5'-monophosphate while emtricitabine is a synthetic nucleoside analogue of cytidine. Both emtricitabine and tenofovir inhibit HIV-1 reverse transcriptase, resulting in DNA chain termination.
Precaution
Lactic Acidosis/Severe Hepatomegaly With Steatosis. Liver impairment. Renal impairment; avoid in CrCl <30ml/min and in patients on dialysis. Pregnancy. Not to be used with other emtricitabine, tenofovir disoproxil fumarate or other cytidine analogues (e.g. lamivudine and zalcitabine) preparations. Increased risk for severe and potentially fatal hepatic adverse reactions in patients with HIV and hepatitis B or C virus co-infection treated with antiretroviral agents. If combination drug is discontinued in patients co-infected with HIV and HBV, monitor hepatic function for several months for acute exacerbation of hepatitis. Discontinue therapy if there is a rapid rise in aminotransferase concentrations, progressive hepatomegaly or...
... Show moreSide Effect
>10%
Diarrhea,Nausea,Fatigue,Headache,Dizziness,Depression,Insomnia,Abnormal dreams,Rash
1-10%
Note: includes adverse effects grade 2-4
Diarrhea (9%),Nausea (9%),Fatigue (9%),Depression (9%),Sinusitis (8%),URI infections (8%),Dizziness (8%),Rash event (7%),Headache (6%),Nasopharyngitis (5%),Insomnia (5%),Vomiting (2%)
Potentially Fatal: Lactic acidosis and severe hepatomegaly with steatosis.
Pregnancy Category Note
Pregnancy Data on the use during pregnancy from observational studies have shown no increased risk of major birth defects Available data from the Antiretroviral Regnancy Registry (APR) show no increase in the overall risk of major birth defects with first trimester exposure for emtricitabine (2.3%) or tenofovir DF (2.1%) compared with the background rate for major birth defects of 2.7% Pregnant women with HIV infection should continue antiretroviral drugs according to current guidelines during pregnancy to decrease maternal-fetal viral transmission (https://aidsinfo.nih.gov) Lactation Emtricitabine and tenofovir have been shown to be present in human breast milk HIV-1 infected women The CDC...
... Show moreInteraction
Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of both tenofovir and emtricitabine or co-administered drug if taken with drugs that are eliminated by active tubular secretion. Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use. Do not use emtricitabine with lamivudine due to similar resistance profile. Increased...
... Show moreব্যবসার জন্য পাইকারি দামে পণ্য কিনতে রেজিস্টেশন করুন
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Incepta Pharmaceuticals Ltd.
Generic: Emtricitabine + Tenofovir disoproxil
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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.