12-24 Hours
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Synthox-25
Healthcare Pharmaceuticals Ltd.
Generic: Levothyroxine Sodium
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Synthox-25 does not cause any harmful side effects.
SAFE IF PRESCRIBED
Synthox-25 is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
SAFE IF PRESCRIBED
Synthox-25 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Synthox-25 does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Synthox-25 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Synthox-25 in patients with liver disease. Please consult your doctor.
Medicine Overview of Synthox-25 25mcg tablet
Introduction
Synthox-25 is a medicine used to treat an underactive thyroid gland (hypothyroidism). It replaces the hormone which was not being produced by your thyroid gland in sufficient quantity and helps regulate your body’s energy and metabolism. Before you start taking Synthox-25, your doctor will do a blood test to see what dose you need. Once you start taking the medicine, you will have regular blood tests to see how well it is working, and the dose may be adjusted from time to time. Take this medicine exactly as directed by your doctor. It is best taken on an empty stomach...
... Show moreUses of Synthox-25
- Hypothyroidism
Side effects of Synthox-25
Common
- Palpitations
- Vomiting
- Anxiety
- Diarrhea
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Weight loss
- Nervousness
- Restlessness
How to use Synthox-25
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Synthox-25 is to be taken empty stomach.
How Synthox-25 works
Synthox-25 is a synthetic version of a hormone produced by the thyroid gland. It works by replacing the thyroid hormones that your thyroid gland cannot produce in a sufficient quantity, and relieves the symptoms of hypothyroidism (tiredness, weight gain, and depression).
What if you forget to take Synthox-25?
If you miss a dose of Synthox-25, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Synthox-25 should be taken on an empty stomach (ideally, first thing in the morning). No food, milk, or tea should be taken 1 hour before and 2 hours after taking this medicine.
- It may take 6 to 8 weeks to get the full effect.
- For most people, Synthox-25 can be a lifelong medication. Do not discontinue it without discussing your doctor.
- Inform your doctor if you have diarrhea, nervousness, irritability, sleep disturbances, shaking hands, or chest pain. Your doctor may adjust your dose.
- Leave a gap of at least 4 hours before taking any antacids, calcium or iron supplements, and multivitamins, as these may interfere with the effect of the medicine.
- Get your hormone levels checked regularly and inform your doctor if you notice a significant change in your body weight. The dose may need to be adjusted.
- Inform your doctor before changing the brand of Synthox-25 as all brands may not have the same effect.
Brief Description
Indication
Hypothyroidism, TSH suppression, Myxoedema coma
Administration
Should be taken on an empty stomach with full glass of water. Take on an empty stomach ½-1 hr before meals.
Adult Dose
Oral Mild Hypothyroidism 1.7 mcg/kg or 100-125 mcg PO qDay; not to exceed 300 mcg/day >50 years (or 50 years with CV disease Usual initial dose: 12.5-25 mcg PO qDay May adjust dose by 12.5-25 mcg q4-6weeks until patient becomes euthyroid and serum TSH concentration normalized; adjustments q6-8weeks also used Dose range: 100-125 mcg PO qDay Severe Hypothyroidism Initial: 12.5-25 mcg PO qDay Adjust dose by 25 mcg/day q2-4Week PRN Subclinical Hypothyroidism Initial: 1 mcg/kg PO qDay may be adequate, OR If replacement therapy not initiated, monitor patient annually for clinical status TSH suppression For thyrotropin-dependent well-differentiated thyroid cancer: Doses...
... Show moreChild Dose
Oral Hypothyroidism Age 1-3 months 10-15 mcg/kg/day PO Use lower starting dose (25 mcg/day) if patient at risk of cardiac failure; if initial serum T4 lower than 5 mcg/dL begin treatment at higher dose (50 mcg/day) Age 3-6 months 8-10 mcg/kg/day PO, OR 25-50 mcg/day PO Age 6-12 months 6-8 mcg/kg/day PO, OR 50-75 mcg/day PO Age 1-5 years 5-6 mcg/kg/day PO, OR 75-100 mcg/day PO Age 6-12 years 4-5 mcg/kg/day PO, OR 100-125 mcg/day PO >12 years 2-3 mcg/kg/day PO, OR 150 mcg/day PO Start children with severe or chronic hypothyroidism at 25 mcg/day; adjust dose by 25 mcg...
... Show moreContraindication
Untreated hyperthyroidism; uncorrected adrenal failure; recent MI.
Mode of Action
Levothyroxine Na is a synthetic form of thyroxine which increases the basal metabolic rate (BMR) and the utilisation and mobilisation of glycogen stores and stimulates protein synthesis. It is also involved in normal metabolism, growth and development. These effects are mediated at the cellular level by the thyroxine metabolite, tri-iodothyronine.
Precaution
Patients w/ CV (e.g. angina, heart failure, HTN), DM and diabetes insipidus, epilepsy, pre-existing myasthenia syndrome, long-standing hypothyroidism. Elderly, pregnancy and lactation. Monitoring Parameters Monitor thyroid function test, clinical signs of hypo- and hyperthyroidism, heart rate and BP.
Lactation: Enters breast milk; use caution
Side Effect
Nervousness, excitability, tremor, muscle weakness, fatigue, cramps; sweating, flushing, heat intolerance, headache, fever, insomnia, tachycardia, palpitations, restlessness, anginal pain, HTN, severe depression, difficulty in sleeping, excessive wt loss; menstrual irregularities; diarrhoea, vomiting, psychosis or agitation. Increased bone resorption and reduced bone mineral density, especially in post-menopausal women; elevated LFT.
Potentially Fatal: Thyrotoxic crisis including convulsions, cardiac arrhythmia, heart failure, coma.
Interaction
Reduced absorption w/ iron, antacids, bile acid sequestrants, colestyramine, simeticone, Ca carbonate, sucralfate, cation exchange resins. Reduced tri-iodothyronine serum levels w/ amiodarone and propranolol. Reduced serum levels of thyroxine w/ carbamazepine, phenytoin, phenobarbital, rifampicin, lithium, oestrogens, sertraline. Androgens may decrease levothyroxine-binding globulins serum levels. May alter requirements of antidiabetic drugs. Increased risk of significant HTN and tachycardia w/ ketamine. Increased metabolic demands w/ sympathomimetics (e.g. epinephrine). May increase anticoagulant effect of warfarin.
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