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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Azactum does not cause any harmful side effects.
SAFE IF PRESCRIBED
Azactum is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Azactum is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Azactum does not usually affect your ability to drive.
CAUTION
Azactum should be used with caution in patients with kidney disease. Dose adjustment of Azactum may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
SAFE IF PRESCRIBED
Azactum is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Azactum may not be needed in these patients. Please consult your doctor.
Medicine Overview of Azactum 1gm/vial injection
Introduction
Azactum is an antibiotic used to prevent or treat a wide variety of bacterial infections. This may include infections of the urinary tract, blood, brain, ear, skin, and soft tissue, abdomen, bone, windpipe and lungs. Azactum is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead...
... Show moreUses of Azactum
- Severe bacterial infections
Side effects of Azactum
Common
- Rash
- Injection site reactions (pain, swelling, redness)
- Vomiting
- Nausea
- Diarrhea
How to use Azactum
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Azactum works
Azactum is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Quick Tips
- You have been prescribed Azactum for the treatment of bacterial infections.
- It is given by an injection or drip into a vein or into a muscle in the buttock or thigh.
- Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Bone and joint infections, Intra-abdominal infections, Lower respiratory tract infections, Meningitis, Septicaemia, Skin and soft tissue infections, Pelvic infections, Gonorrhoea, Cystitis, Urinary tract infections, Cystic fibrosis
Administration
Reconstitution:
IM: Reconstitute vial w/ at least 3 mL of sterile water for inj, sterile bacteriostatic water for inj, normal saline, or bacteriostatic NaCl per g of aztreonam; immediately shake vigorously.
IV: Bolus inj: Reconstitute vial w/ 6-10 mL of sterile water for inj.
Infusion: Reconstitute vial w/ at least 3 mL of sterile water for inj per g of aztreonam; immediately shake vigorously. Then further dilute in an appropriate soln for infusion to a final concentration of <2%.
Adult Dose
Adult: IV/IM Gm-ve infections 1-8 g/day in divided doses depending on severity. Max: 8 g/day.
UTI 0.5-1 g 8-12 hrly.
IM Cystitis; Gonorrhoea 1 g as a single dose.
Child Dose
Child: IV, IM 90–120 mg/kg/day q6–8hr
Infants >1 wk: 30 mg/kg every 6 or 8 hr
Renal Dose
Renal impairment
CrCl 10-30 mL/min: 1-2 g loading dose, then 50% of usual dosage
CrCl <10 mL/min: 1-2 g loading dose, then 25% of usual dosage
Contraindication
Hypersensitivity to aztreonam.
Mode of Action
Aztreonam inhibits bacterial cell wall synthesis due to its high affinity for penicillin-binding protein 3 (PBP-3) of gm-ve bacteria. It is highly resistant to hydrolysis by many narrow-spectrum β-lactamases. It is also active against most Enterobacteriaceae (including E. coli, Citrobacter, Enterobacter, Klebsiella, Proteus, Providencia, Salmonella, Serratia, Shigella, Yersinia spp. and Morganella morganii).
Precaution
History of β-lactam hypersensitivity. Renal and hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor for signs of anaphylaxis during 1st dose; periodic LFT. Consider measuring FEV1 prior to initiation of inhalation therapy.
Lactation: Drug is excreted in milk in low concentrations; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Side Effect
>10%
Injection
Pain at injection site (12%; children); (2%; adults)
Increase in serum transaminases (4-6%)
Neutropenia (3-11%, children); (<1%, adults)
1-10%
Rash (4%),Thrombocytopenia (4%, children); (<1% adults),Diarrhea (1%),Nausea (1%),Vomiting (1%),Fever (<1%)
< 1%
Abnormal taste,Anaphylaxis,Anemia,Angioedema,Aphthous ulcer,Breast tenderness,Bronchospasm,Clostridium difficile-associated diarrhea (CDAD),Confusion,Diplopia,Dizziness,Dsypnea,Electrocardiographic changes (transient),Erythema multiforme,Eosinophilia,Fever,Flushing,Halitosis,Headache,Hepatitis,Hypotension,Insomnia,Jaundice,Leukocytosis,Neutropenia,Pancytopenia,Seizures,Thrombocytopenia,Tinnitus,Tongue numbness,Toxic epidermal necrolysis,Urticaria,Vaginitis,Vertigo,Weakness,Wheezing
Potentially Fatal: Clostridium difficile-associated diarrhoea from mild diarrhoea to fatal colitis.
Pregnancy Category Note
Pregnancy category: B
Lactation: Drug is excreted in milk in low concentrations; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Interaction
Concurrent use w/ oral anticoagulants may increase prothrombin time.
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