12-24 Hours
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Glypressin
Radiant Pharmaceuticals Ltd.
Generic: Terlipressin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Glypressin. Please consult your doctor.
UNSAFE
Glypressin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Information regarding the use of Glypressin during breastfeeding is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
It is not known whether Glypressin alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CONSULT YOUR DOCTOR
There is limited information available on the use of Glypressin in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Glypressin in patients with liver disease. Please consult your doctor.
Medicine Overview of Glypressin 1mg/8.5ml injection
Introduction
Glypressin is used in the treatment of bleeding esophageal varices (bleeding from dilated veins in the food pipe leading to your stomach). It narrows the walls of blood vessels and decreases the blood flow into the affected veins. Glypressin is given by a healthcare professional. You should not self-administer this medicine at home. Your doctor will decide the dose and how often you should take them. It is given only to patients with severe or life-threatening bleeding in the food pipe (esophagus). Using of this medicine can cause some common side effects such as headache, slow heart rate, high blood...
... Show moreUses of Glypressin
- Bleeding esophageal varices
Side effects of Glypressin
Common
- Abdominal cramp
- Diarrhea
- Headache
- High blood pressure
- Slow heart rate
How to use Glypressin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Glypressin works
Glypressin works on the walls of blood vessels, causing them narrow and decrease the blood flow into the affected veins. This helps to stop or slow the bleeding.
What if you forget to take Glypressin?
If you miss a dose of Glypressin, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Glypressin is given as an injection into veins under the supervision of a doctor.
- It makes you feel dizzy or lightheaded. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.
Brief Description
Indication
Acute oesophageal variceal haemorrhage, Hepatorenal syndrome type 1
Administration
Powder for solution for inj: Slowly add the contents of the solvent ampoule to the powder vial and roll gently until completely dissolved. Dilute further with 10 mL NaCl 0.9% solution for inj.
Adult Dose
Intravenous Acute oesophageal variceal haemorrhage Adult: As powder and solvent for solution for inj: Initially, 1-2 mg, then 1 mg 4-6 hourly. Max duration of treatment: 72 hours. As solution for inj: Initially, 2 mg 4 hourly, maintain until bleeding is controlled for 24 hours or up to max of 48 hours. Subsequent doses may be reduced to 1 mg 4 hourly in patients weighing <50 kg or if adverse reaction occur. Hepatorenal syndrome type 1 Adult: Initially, 1 mg 6 hourly via slow bolus inj, may be increased up to max 2 mg 4-6 hourly if serum creatinine has...
... Show moreContraindication
Unstable angina, recent MI, septic shock with low cardiac output. Pregnancy.
Mode of Action
Terlipressin, an inactive prodrug, is converted via enzymatic cleavage to lysine-vasopressin. The active vasopressin selectively causes splanchnic and extrarenal vasoconstriction by stimulation of V1 receptors on vascular smooth muscle, thereby reducing splanchnic blood flow and portal pressure. It also increases systemic mean arterial pressure and decrease heart rate. It has minimal action on V2 receptors responsible for its antidiuretic effects.
Precaution
Patient with uncontrolled hypertension, severe asthma or COPD, cardiac disease, arrhythmias, atherosclerosis, vascular disease (cerebral or peripheral), electrolyte and fluid disturbances. Renal impairment (especially chronic renal failure). Lactation.
Side Effect
Significant: QT interval prolongation, ventricular arrhythmias (including Torsade de pointes), cutaneous ischaemia and necrosis.
Cardiac disorders: Tachycardia, bradycardia, pulmonary oedema, dyspnoea.
Gastrointestinal disorders: Intestinal ischaemia, abdominal cramps, diarrhea, nausea, vomiting.
Metabolism and nutrition disorders: Rarely, hyponatraemia, hyperglycaemia.
Nervous system disorders: Convulsion, headache.
Reproductive system and breast disorders: Uterine ischaemia.
Respiratory, thoracic and mediastinal disorders: Bronchospasm, respiratory failure.
Vascular disorders: Hypertension, hypotension, pallor.
Interaction
Increases the hypotensive effect of non-selective β-blockers. Concomitant use of drugs known to induce bradycardia (e.g. propofol, sufentanil) may lower heart rate and cardiac output. May trigger ventricular arrhythmias, including Torsade de pointes, when used with drugs that can prolong QT interval (e.g. class IA and III antiarrhythmics, erythromycin, certain antihistamines and TCAs), or with drugs that may cause hypokalaemia or hypomagnesaemia.
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