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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Exepress.
CONSULT YOUR DOCTOR
Exepress may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Exepress is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Exepress may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Exepress is safe to use in patients with kidney disease. No dose adjustment of Exepress is recommended.
However, inform your doctor if you have any underlying kidney disease. Regular monitoring of blood pressure is recommended for dose adjustment.
CAUTION
Exepress should be used with caution in patients with liver disease. Dose adjustment of Exepress may be needed. Please consult your doctor.
Use of Exepress is not recommended in patients with severe liver disease.
Medicine Overview of Exepress 12.5mg Tablet
Introduction
Exepress is a medicine used to treat high blood pressure, heart related chest pain (angina) and heart failure. It works by relaxing the blood vessels, so blood can flow more easily to the heart. Lowering blood pressure helps to prevent future heart attack and stroke. Exepress should be taken with food. You should take it in the dose and duration as advised by the doctor. It is important to take it even if you feel well or if your blood pressure is controlled. You should not stop this medicine without talking to the doctor as your condition could get worse....
... Show moreUses of Exepress
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Heart failure
Side effects of Exepress
Common
- Decreased blood pressure
- Headache
- Fatigue
- Dizziness
How to use Exepress
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Exepress is to be taken with food.
How Exepress works
Exepress is an alpha and beta blocker. It works by slowing down the heart rate and relaxing blood vessels which makes the heart more efficient at pumping blood around the body.
Quick Tips
- It should be taken with food.
- Check your blood pressure 1 week after starting Exepress, and inform your doctor if it has not improved.
- Exepress may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- It is best to avoid drinking alcohol while taking Exepress as it may make the side effects worse.
- Do not stop taking Exepress suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.
Brief Description
Indication
Hypertension, Congestive heart failure, Myocardial infarction, Left ventricular dysfunction, Angina pectoris
Administration
Should be taken with food.
Adult Dose
Congestive Heart Failure Immediate release 3.125 mg PO q12hr for 2 weeks, then increased every 2 weeks as tolerated to 6.25 mg, 12.5 mg, or 25 mg PO twice daily Maximum recommended dosage (mild-to-moderate heart failure): 85 kg: 50 mg PO twice daily Maximum recommended dosage (severe heart failure): 25 mg PO twice daily Extended release 10 mg/day PO; maintained for 1-2 weeks if tolerated; may be increased to 20 mg/day, 40 mg/day, or 80 mg/day PO if necessary Hypertension Immediate release: 6.25 mg PO twice daily initially; after 7-14 days, increased as tolerated, first to 12.5 mg PO twice...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment: No dosage adjustments necessary
Contraindication
Hypersensitivity; severe chronic heart failure, bronchial asthma or related bronchospastic conditions; severe hepatic impairment. Patients with NYHA class IV cardiac failure, 2nd or 3rd ° AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock or severe bradycardia. Lactation.
Mode of Action
Carvedilol is a nonselective beta-adrenoreceptor and alpha-adrenergic blocking activity. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation.
Precaution
Avoid abrupt withdrawal as it may precipitate thyroid storm or exacerbate hyperthyroidism. Liver injury; vascular disease, renal failures, suspected phaeochromocytoma and prinzmetal's variable angina; worsening cardiac failure or fluid retention during increase in dosage of carvedilol; diabetic patients. Pregnancy.
Lactation: Unknown whether drug is excreted in milk; not recommended
Side Effect
>10%
Dizziness (2-32%),Fatigue (4-24%),Hypotension (9-20%),Weight gain (10-12%),Hyperglycemia (5-12%),Diarrhea (1-12%)
1-10%
Bradycardia (2-10%),Nausea (2-9%),Cough (5-8%),Headache (5-8%),Atrioventricular block, edema (1-7%),Angina (1-6%),Hpercholesterolemia (1-4%),Hypertriglyceredemia (1%),Vomiting (1-6%),Dyspnea (>3%),Syncope (3%),Rhinitis (2%)
Frequency Not Defined
Hypertension,Palpitations,Insomnia,Somnolence,Skin rash,Hepatotoxicity,Impotence,Bronchospasm,Rales,Depression,Decreased exercise tolerance,Raynaud phenomenon,Increased triglyceride levels and insulin resistance with decreased high-density lipoprotein (HDL) levels
Pregnancy Category Note
Pregnancy Available data in pregnant women are insufficient to determine whether there are drug-associated risks of adverse developmental outcomes; there are risks to mother and fetus associated with poorly controlled hypertension in pregnancy; the use of beta blockers during third trimester of pregnancy may increase risk of hypotension, bradycardia, hypoglycemia, and respiratory depression in neonates; in animal reproduction studies, there was no evidence of adverse developmental outcomes at clinically relevant doses; observe newborns for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression and manage accordingly Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications...
... Show moreInteraction
Decreased serum levels w/ rifampicin. Combination w/ Ca channel blockers (e.g. verapamil and diltiazem) can lead to bradycardia and myocardial depression. Potentiates insulin-induced hypoglycaemic action. May increase hypoglycaemic effects of antidiabetic agents. Increased risk of bradycardia w/ digoxin. Increased risk of hypotension and bradycardia w/ reserpine, MAOIs, clonidine. May increase ciclosporin concentrations. Concurrent use w/ ether, cyclopropane, trichloroethylene may increase the risk of hypotension and heart failure.
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