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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Ezetim.
CONSULT YOUR DOCTOR
Ezetim may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Ezetim is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Ezetim may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Ezetim is safe to use in patients with kidney disease. No dose adjustment of Ezetim is recommended.
CAUTION
Ezetim should be used with caution in patients with liver disease. Dose adjustment of Ezetim may be needed. Please consult your doctor.
Use of Ezetim is not recommended in patients with moderate to severe liver disease.
Medicine Overview of Ezetim 10mg Tablet
Introduction
Ezetim is a medicine used to treat high cholesterol. This medicine helps by lowering "bad" cholesterol (LDL) levels in blood. Cholesterol is a fatty substance that builds up in your blood vessels and causes narrowing, which may lead to a heart attack or stroke. Ezetim should be taken in the dose and duration as advised by the doctor. You can take it at any time of day but try to take it at the same time each day. Most people with high cholesterol do not feel ill, but if you stop taking this medicine, your condition could get worse. This...
... Show moreUses of Ezetim
- High cholesterol
Side effects of Ezetim
Common
- Joint pain
- Sinus inflammation
- Diarrhea
- Respiratory tract infection
How to use Ezetim
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ezetim may be taken with or without food, but it is better to take it at a fixed time.
How Ezetim works
Ezetim is a cholesterol absorption inhibitors. It reduces the cholesterol absorption from the intestine and lowers the levels of total cholesterol and "bad" cholesterol (LDL) in the blood.
What if you forget to take Ezetim?
If you miss a dose of Ezetim, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Ezetim treats high cholesterol by lowering bad cholesterol (LDL) and raising good cholesterol (HDL). This helps prevent heart attack and stroke.
- Take it in addition to regular exercise and low-fat diet.
- Notify your doctor if you experience muscle symptoms (pain or weakness), particularly if accompanied with fever.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Hyperlipidaemias, Homozygous familial sitosterolaemia, Hypercholesterolaemia
Administration
May be taken with or without food.
Adult Dose
Oral
Hyperlipidaemias; Homozygous familial sitosterolaemia
Adult: 10 mg once daily.
Hepatic impairment
Mild (Child-Pugh class A): Dose adjustment not necessary
Moderate to severe (Child-Pugh class B or C): Not recommended
Child Dose
Child: >10 yr: 10 mg once daily.
Renal Dose
Renal impairment
Monotherapy: No dosage adjustment required
Moderate to severe: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg
Contraindication
Hypersensitivity; moderate to severe liver disease or unexplained serum transaminase elevation. Children <10 yr, lactation.
Mode of Action
Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, thus decreasing its delivery to the liver. This results in decrease in cholesterol stores within the liver and an increase in cholesterol clearance from the blood.
Precaution
Renal or mild hepatic impairment. Monitor LFTs. Immediately discontinue ezetimibe and any HMG-CoA reductase inhibitor or fibrate if myopathy is diagnosed or suspected. Exclude or treat secondary causes of dyslipidaemia prior to initiating therapy.
Lactation: Excretion in milk unknown; use with caution
Side Effect
1-10%
Diarrhea (4%),Upper respiratory tract symptoms (2-4%),Cough (2-4%),Pain in extremity (3%),Sinusitis (3%),Arthralgia (2-3%),Fatigue (2%),Influenza (2%),Increased liver transaminases (with HMG-CoA reductase inhibitors; >3 x ULN; 1%)
Pregnancy Category Note
Pregnancy category: C
Lactation: Excretion in milk unknown; use with caution
Interaction
Reduced absorption w/ colestyramine. Increased plasma concentrations w/ ciclosporin. Concomitant use w/ oral anticoagulants may result in increased INR.
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