12-24 Hours
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Tygelin
Opsonin Pharma Limited
Generic: Tigecycline
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Tygelin does not cause any harmful side effects.
CONSULT YOUR DOCTOR
Tygelin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Tygelin is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Tygelin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Tygelin is safe to use in patients with kidney disease. No dose adjustment of Tygelin is recommended.
CAUTION
Tygelin should be used with caution in patients with severe liver disease. Dose adjustment of Tygelin may be needed. Please consult your doctor.
Medicine Overview of Tygelin 50mg/Vial injection
Introduction
Tygelin is an antibiotic that fights bacteria. It is used to treat severe infections of the body like skin, intra-abdominal infections, and community-acquired bacterial pneumonia. It works by killing the bacteria that cause these problems. But, it will not treat a viral infection. Tygelin is commonly used to treat critically ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have...
... Show moreUses of Tygelin
- Severe bacterial infections
Side effects of Tygelin
Common
- Headache
- Vomiting
- Nausea
- Increased liver enzymes
- Stomach pain
- Diarrhea
How to use Tygelin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Tygelin works
Tygelin is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Quick Tips
- Tygelin is an antibiotic that is usually only given in the hospital for serious infections.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
- It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Tygelin affects you.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Brief Description
Indication
Complicated intra-abdominal infections; Complicated skin and skin structure infections, Community-acquired pneumonia
Administration
IV Preparation
Reconstitute each vial with 5.3 mL NS or D5W to achieve a conc of 10 mg/mL
IV Administration
Infuse over 30-60 min
Adult Dose
The recommended daily dose is as follows: Adults: The recommended dosage regimen for Tigecycline is an initial dose of 100 mg, followed by 50 mg every 12 hours. Intravenous (IV) infusions of Tigecycline should be administered over approximately 30 to 60 minutes every 12 hours. The duration of therapy should be guided by the severity and site of the infection and the patient's clinical and bacteriological progress. The recommended duration of treatment with Tigecycline for complicated skin and skin structure infections or for complicated intra-abdominal infections is 5 to 14 days and for Community-acquired pneumonia is 7-14 days. Hepatic impairment:...
... Show moreChild Dose
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment: No dosage adjustment needed.
Contraindication
Hypersensitivity. Hospital-acquired pneumonia and ventilator-associated pneumonia. Use during tooth development.
Mode of Action
Tigecycline is a glycylcycline antibiotic which prevents protein synthesis of the susceptible bacteria by binding to its 30s ribosomal subunit. It is generally considered as bacteriostatic agent; w/ bactericidal activity against S. pneumonia and L. pneumophilia. Tigecycline antibacterial activity covers facultative gm+ve (including MRSA, vancomycin-susceptible Enterococcus faecalis) and gm-ve bacteria, and anaerobic bacteria.
Precaution
Hypersensitivity to tetracyclines. Use tigecycline in situations when alternative treatments are not suitable. Patients w/ complicated intra-abdominal infections secondary to clinically apparent intestinal perforation. Hepatic impairment. Pregnancy and lactation.
Side Effect
>10%
Nausea (29.5%),Vomiting (19.7%),Diarrhea (12.7%)
1-10%
Infection (8.3%),Fever (7.1%),Abd pain (6.8%),Headache (5.9%),HTN (4.9%),Anemia (4.2%),Dizziness (3.5%),Dyspnea (2.9%),Pruritus (2.6%),Rash (2.4%),Hypotension (2.3%),Insomnia (2.3%)
Interaction
Increased warfarin serum levels. May decrease efficacy of oral contraceptives.
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