12-24 Hours
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Methoflex 500
DBL Pharmaceuticals Ltd.
Generic: Methocarbamol
Safety Advices
বাংলা
English
UNSAFE
Methoflex 500 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Methoflex 500 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Methoflex 500 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Methoflex 500 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Methoflex 500 should be used with caution in patients with kidney disease. Dose adjustment of Methoflex 500 may be needed. Please consult your doctor.
CAUTION
Methoflex 500 should be used with caution in patients with liver disease. Dose adjustment of Methoflex 500 may be needed. Please consult your doctor.
Medicine Overview of Methoflex 500mg tablet
Introduction
Methoflex 500 is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms. Methoflex 500 is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. It may be only part of a treatment program that includes other medicines and therapies. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting,...
... Show moreUses of Methoflex 500
- Muscle relaxation
Side effects of Methoflex 500
Common
- Sleepiness
- Dryness in mouth
How to use Methoflex 500
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Methoflex 500 works
Methoflex 500 is a muscle relaxant. It works on the centres in the brain and spinal cord to relieve muscle stiffness or spasm without reduction in strength. This improves pain and movement of muscles.
What if you forget to take Methoflex 500?
If you miss a dose of Methoflex 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Methoflex 500 provides relief from rigidity, tension and stiffness in muscles (spasticity) that may occur due to various conditions affecting the nervous system.
- Take it with or after food or a glass of milk.
- Methoflex 500 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Methoflex 500 as it may cause excessive drowsiness.
- Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
- Do not stop taking it suddenly without talking to your doctor if you've been on it for a long time.
Brief Description
Indication
Muscle Spasm, Tetanus
Administration
IV Administration
Direct IV: Administer undiluted at not to exceed 3 mL (=300 mg undiluted)/min
Infusion: Dilute 1 g with up to 250 mL D5W or NS; avoid extravasation, since injection is hypertonic
Administer IV while in recumbent position
Maintain position 15-30 min following infusion
IM Administration
Not to exceed 500 mg (5 mL undiluted) should be given into each gluteal region
Adult Dose
Oral Muscle spasm Adult: Initially: 1.5 g q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr Parenteral 1 g IV/IM; additional doses at q8hr until PO; not to exceed 3 g/day Total parenteral dose should not exceed 3 g/day for >3 days, unless treating tetanus; if condition persists, may repeat therapy after drug-free interval of 48 hr Intravenous Tetanus Adult: Adjunct therapy: Initial 1-2 g IV injection (at 300 mg/min), THEN Additional 1-2 g IV infusion for total dose of 3 g initially May repeat 1-2 g IV q6hr until can give NG...
... Show moreChild Dose
Tetanus
15 mg/kg/dose IV q6hr PRN or 500 mg/m²/dose; not to exceed 1.8 g/m²/day for 3 days only
Muscle Spasm
16 years: 1500 mg PO q6hr for 48-72 hours; not to exceed 8 g/day THEN decrease to 4-4.5 g/day divided q4-8hr
Renal Dose
Renal failure: Not studied; parenteral dosage form contraindicated due to presence of polyethylene glycol
Contraindication
Hypersensitivity, Do not admin parenteral solutions in patients with renal impairment, epilepsy or history of epilepsy. Coma or pre-coma states, brain damage, myasthenia gravis
Mode of Action
Unknown; Methocarbamol is a centrally acting skeletal muscle relaxant whose precise mode of action is not known. It is said to cause general depression of the central nervous system.
Precaution
May cause drowsiness/dizziness; patients should not ingest alcohol or other CNS depressants
May take with food to avoid stomach upset
Half-life increases with hepatic impairment
IV formulation not for use in renal impairment (contains polyethylene glycol; injection rate should not exceed 3 mL/min
May interfere with screening tests for 5-HIAA and vanillylmandelic acid (VMA)
Use injection with caution in patients with a history of seizures
Sedative effects potentiated when used with other sedatives
Medication is poorly tolerated in the elderly
Pediatric IV dosing approved only for tetanus
Lactation: Not known if excreted in breast milk; use caution
Side Effect
Nausea, anorexia, fever, headache, blurred vision, lassitude, drowsiness, dizziness, restlesness, anxiety, confusion, convulsions; hypersensitivity reactions e.g. rashes, pruritus, urticaria, angiodema. Parenteral: Flushing and a metallic taste; incoordination, diplopia, nystagmus, vertigo; sloughing and thrombophloebitis at the site of inj.
Potentially Fatal: Parenteral: Syncope, hypotension, bradycardia, anaphylaxis.
Interaction
Action potentiated by alcohol and other CNS depressants. May inhibit effect of pyridostigmine, use with caution with anticholinesterase agents.
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