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Fibrostat
Globe Pharmaceuticals Ltd.
Generic: Tranexamic Acid
Safety Advices
বাংলা
English
UNSAFE
Fibrostat may cause excessive drowsiness with alcohol.
SAFE IF PRESCRIBED
Fibrostat is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Fibrostat is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Fibrostat does not usually affect your ability to drive.
CAUTION
Fibrostat should be used with caution in patients with kidney disease. Dose adjustment of Fibrostat may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Fibrostat is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Fibrostat may not be needed in these patients. Please consult your doctor.
Medicine Overview of Fibrostat 500mg/5ml Injection
Introduction
Fibrostat is used to treat bleeding. It helps to prevent or reduce bleeding in conditions like tooth removal, heavy periods, dysfunctional uterine bleeding, nosebleed and in any oral, prostate or bladder surgery. Fibrostat is an anti-fibrinolytic. It works by preventing the breakdown of clots which leads to stoppage of bleeding. This medicine must be taken in the dose and duration as advised by the doctor. You should not take it if you have any known allergy from this medicine. The most common side effects may be injection site reactions such as tiredness, nasal congestion or pain in muscle, bone or...
... Show moreUses of Fibrostat
- Bleeding
Side effects of Fibrostat
Common
- Tiredness
- Nasal congestion (stuffy nose)
- Musculoskeletal (bone, muscle or joint) pain
How to use Fibrostat
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Fibrostat is to be taken with food.
How Fibrostat works
Fibrostat is an anti-fibrinolytic. It works by preventing the breakdown of blood clots to control excessive bleeding during periods, or after surgery.
What if you forget to take Fibrostat?
If you miss a dose of Fibrostat, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Fibrostat helps prevent or reduce heavy bleeding post surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
- Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
- If taking for heavy periods, take it on the first day as taking it before or after will not have any benefit.
- Your doctor may monitor your vision regularly while you are taking this medicine.
- Inform your doctor if you have a history of kidney or liver disease.
- Inform your doctor if there is no improvement in your bleeding after using this medicine for three consecutive periods.
Brief Description
Indication
Haemorrhage, Hereditary angioedema
Administration
May be taken with or without food.
Adult Dose
Oral
Short-term management of haemorrhage
Adult: 1-1.5 g or 15-25 mg/kg bid or tid.
Management of hereditary angioedema
Adult: 1-1.5 g bid or tid.
Intravenous
Short-term management of haemorrhage
Adult: 0.5-1 g or 10 mg/kg tid or 25-50 mg/kg daily by continuous infusion.
Child Dose
Oral
Short-term management of haemorrhage
Child: 25 mg/kg bid or tid.
Management of hereditary angioedema
Child: 25 mg/kg bid or tid.
Intravenous
Short-term management of haemorrhage
Child: 10 mg/kg bid or tid.
Renal Dose
Renal impairment: Adjust dose based on serum creatinine concentration: 120-250 micromol/l: 15 mg/kg bid daily; 250-500 micromol/l: 15 mg/kg once daily; >500 micromol/l: 7.5 mg/kg once daily or 15 mg/kg once every 48 hr.
Contraindication
Severe renal failure, active intravascular clotting, thromboembolic disease, colour vision disorders, subarachnoid bleeding.
Mode of Action
Tranexamic acid is an antifibrinolytic agent that competitively inhibits breakdown of fibrin clots. It blocks binding of plasminogen and plasmin to fibrin, thereby preventing haemostatic plug dissolution.
Precaution
Mild to moderate renal impairment, irregular menstrual bleeding, previous history of thromboembolic disease, haematuria. Monitor closely in disseminated intravascular coagulation. Monitor LFT and eye examination regularly during long-term use. Discontinue if disturbance in colour vision occurs. Avoid IV inj rate >1 ml/minute due to risk of hypotension. Pregnancy, lactation.
Side Effect
>10%
Headache (50.4%),Nasal and sinus symptoms (25.4%),Back pain (20.7%),Abdominal pain (19.8%),Musculoskeletal pain (11.2%)
1-10%
Arthralgia (6.9%),Muscle cramps and spasms (5.8%),Migraine (6%),Anemia (5.6%),Fatigue (5.2%)
Frequency Not Defined
Visual abnormalities,Hypotension (with rapid injection),Nausea,Vomiting,Diarrhea
Interaction
Potentially Fatal: Increased risk of thrombus formation with estrogens, Factor IX complex concentrates or anti-inhibitor coagulant concentrates. Increased risk of fatal thrombotic complications with tretinoin in acute promyelocytic leukaemia.
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