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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Unitin-Plus. Please consult your doctor.
UNSAFE
Unitin-Plus is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Unitin-Plus is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Unitin-Plus may cause side effects which could affect your ability to drive.
Your night vision may get worse during your treatment. This can happen suddenly. Drowsiness and dizziness have been reported very rarely. This may affect your driving ability.
SAFE IF PRESCRIBED
Unitin-Plus is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Unitin-Plus may not be needed in these patients. Please consult your doctor.
If you experience excessive tiredness, puffy eyes and difficulty in urination while taking this medicine, inform your doctor and stop the therapy.
UNSAFE
Unitin-Plus is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Unitin-Plus 20mg capsule
Introduction
Unitin-Plus belongs to a group of medicines called retinoids, which are closely related to vitamin A derivative. It is used to treat severe acne that has not responded to other treatments. Unitin-Plus should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at the same day, each day to avoid a missed dose. It may take several weeks for your symptoms to improve but keep using it regularly to get the most benefit. If you notice no improvement after a few weeks, see your doctor again. Using more medicine or...
... Show moreUses of Unitin-Plus
- Acne
Side effects of Unitin-Plus
Common
- Dry skin
How to use Unitin-Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Unitin-Plus is to be taken with food.
How Unitin-Plus works
Unitin-Plus is a derivative of vitamin A. It acts on glands (sebaceous) to reduce the production of a natural substance (sebum) that causes acne. Also, the controlled sebum production kills acne-causing bacteria. It also works as an anti-inflammatory to decrease inflammation (redness and swelling).
What if you forget to take Unitin-Plus?
If you miss a dose of Unitin-Plus, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it with food.
- Avoid exposure to sunlight while using Unitin-Plus. Use protective measures such as sun-cream or protective clothing.
- Avoid face waxing and laser treatment while using this medicine as it makes your skin more fragile.
- Avoid taking tetracycline as it may reduce the Unitin-Plus activity.
- Do not take Unitin-Plus if you are pregnant, planning pregnancy or breastfeeding.
- It may cause dryness of mouth, lips, and eyes. Drink plenty of water, use moisturiser and avoid wearing contact lenses. Inform your doctor if it bothers you.
Brief Description
Indication
Acne
Administration
Should be taken with food.
Adult Dose
Oral
Severe, Recalcitrant Nodular Acne
Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics
Adult: 0.5-1 mg/kg/day PO divided BID for 15-20 weeks
Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk
Hepatic impairment: Contraindicated.
Child Dose
Severe, Recalcitrant Nodular Acne
Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics
12 years: 0.5-1 mg/kg/day PO divided BID for 15-20 weeks
Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk
Renal Dose
Renal impairment: Severe: Reduce initial dose (e.g. 10 mg daily), then gradually increase to 1 mg/kg as necessary.
Contraindication
Pregnancy, lactation.
Mode of Action
Isotretinoin is a synthetic retinoid which reduces sebaceous gland size and sebum production. It also regulates cell proliferation and differentiation.
Precaution
Preexisting or predisposition to hypertriglyceridaemia (e.g. DM, obesity or increased alcohol intake). Monitor triglyceride levels. Monitor blood lipids and LFTs at wkly or bi-wkly intervals. Monitor blood glucose in known or suspected DM patients. Genetic predisposition for age-related osteoporosis, history of childhood osteoporosis, osteomalacia or other bone metabolism disorders. Anorexia nervosa. History of psychiatric disorder. May impair night vision. Avoid wax epilation and skin resurfacing procedures for at least 6 mth. Avoid prolonged exposure to UV light or sunlight. Discontinue if hearing impairment, abdominal pain, rectal bleeding, severe diarrhoea or adverse ocular effects occur. Patient should not donate blood during...
... Show moreSide Effect
>10%
Cheilitis (90%),Xerosis,Xerostomia,Dry nose,Epistaxis,Pruritus,Conjunctivitis (including blepharoconjunctivitis) (40%),Irritation (40%),Increased erythrocyte sedimentation rates (40%),Thinning of hair (which has persisted in rare instances),Palmoplantar desquamation,Skin fragility,Skin infections (eg, paronychial infections),Rash (including erythema, seborrhea, eczema), photosensitivity,Hypertriglyceridemia (25%),Bone or joint pain,Generalized muscle aches,Arthralgia,Decreased HDLs (15%),Increased LFTs (15%),Increased CPK (12-24%),Decreased hemoglobin concentration and hematocrit,Decreased erythrocyte and leukocyte counts,Increased platelet count
1-10%
Decreased bone mineral density (8.8%),Premature epiphyseal closure (3%)
Frequency Not Defined
Lethargy,Fatigue,Headache,Anorexia,Nausea,Vomiting,Increased appetite,Thirst
Potentially Fatal: Anaphylaxis. Haemorrhagic pancreatitis.
Interaction
Additive toxicity with vitamin A or its derivatives. Decreased efficacy of microdosed progesterone (use 2 forms of contraception). May increase risk of bone loss with phenytoin. May increase risk of osteoporosis with systemic corticosteroids. Reduces plasma levels of carbamazepine.
Potentially Fatal: Increased risk of pseudotumor cerebri with tetracyclines.
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