12-24 Hours
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Amantril 100
ACI Limited
Generic: Amantadine Hydrochloride
Medicine Overview of Amantril 100mg Capsule
বাংলা
English
Indication
Adult: PO Influenza A 100 mg/day for 5 days. Prophylaxis of influenza A 100 mg/day for up to 6 wk. W/ influenza vaccination: up to 3 wk after vaccination.
Elderly: >65 yr: Daily dose of 1 day.
Herpes zoster 100 mg twice daily for 14 days, may continue for another 14 days if pain persists.
Parkinson's disease100 mg/day, up to 100 mg twice daily 1 wk or more. Max: 400 mg/day.
Administration
Enhances the adverse effects of antimuscarinics and levodopa. CNS stimulants, drugs that raise urinary pH.
The concurrent use of Amantadine hydrochloride with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated.
Adult Dose
Patients with CV or liver disease, impaired renal function, recurrent eczema. Elderly. Withdrawal of the drug should be gradual.
Lactation: Drug enters breast milk; not recommended
Renal Dose
Amantadine is a weak dopamine agonist possessing antimuscarinic properties. It alters dopamine release and re-uptake. It also noncompetitively antagonises N-methyl-D-aspartate. As an antiviral drug, it inhibits replication of influenza type A virus.
Contraindication
Oral
Influenza A treatment
Child: 1-9 years or 10 years and 10 years and >40 kg: 100 mg PO q12hr
NOTE: Because of resistance, amantadine is no longer recommended for prophylaxis or treatment of influenza A
Mode of Action
Should be taken with food.
Precaution
Parkinson's disease, Influenza, herpes zoster, drug-induced extrapyramidal reactions
Side Effect
Renal impairment:
CrCl (ml/min)
>35 100 mg daily.
15-35 100 mg every 2-3 days.
<15 Not recommended.
Pregnancy Category Note
1-10%
Agitation,Anorexia,Anxiety,Ataxia,Confusion,Constipation,Depression,Diarrhea,Dizziness,Dream abnormality,Dry nose,Fatigue,Hallucinations,Headache,Insomnia,Irritability,Livedo reticularis,Nausea,Nervousness,Orthostatic hypotension,Peripheral edema,Somnolence,Xerostomia
<1%
Amnesia,CHF,Decreased libido,Dyspnea,Eczematoid dermatitis,Euphoria,Hyperkinesis,Hypertension,Instances of convulsions,Leukopenia,Neutropenia,Oculogyric episodes,Psychosis,Rash,Slurred speech,Urinary retention,Visual disturbances,Vomiting,Weakness
Potentially Fatal: Congestive heart failure, convulsions.
Interaction
Hypersensitivity. Pregnancy and lactation. Epilepsy or other seizure disorders, severe renal impairment and gastric ulceration.
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